Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies
In this thesis Lena Bugge Nordberg assessed clinical aspects of new classification criteria and modern treatment for rheumatoid arthritis (RA). The thesis is based on data from the ARCTIC trial, in which 230 early RA patients were followed for 2 years. Nordberg examined whether the use of ultrasound...
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ftoslouniv:oai:www.duo.uio.no:10852/71049 2023-05-15T14:28:10+02:00 Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies Nordberg, Lena Bugge 2019 http://hdl.handle.net/10852/71049 http://urn.nb.no/URN:NBN:no-74172 en eng Paper I: L. B. Nordberg, S. Lillegraven, A. B. Aga, J. Sexton, E. Lie, H.B. Hammer, I. C. Olsen, T. Uhlig, D. van der Heijde, T. K. Kvien, E. A. Haavardsholm. The impact of ultrasound on the use and efficacy of intra-articular glucocorticoid injections in early rheumatoid arthritis: Secondary analyses from a randomized trial examining the benefit of ultrasound in a clinical tight control regimen. Arthritis Rheumatol 2018;70(8):1192-9. DOI:10.1002/art.40494. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1002/art.40494 Paper II: L. B. Nordberg, S. Lillegraven, E. Lie, A. B. Aga, I. C. Olsen, H. B. Hammer, T. Uhlig, M. K. Jonsson, D. van der Heijde, T. K. Kvien, E. A. Haavardsholm and the ARCTIC working group. Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria. Annals of the Rheumatic Diseases 2017;76(2):341-5. DOI:10.1136/annrheumdis-2015-208873. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1136/annrheumdis-2015-208873 Paper III: L. B. Nordberg, S. Lillegraven, A. B. Aga, J. Sexton, I. C. Olsen, E. Lie, H. B. Hammer, T. Uhlig, D. van der Heijde, T. K. Kvien, E. A. Haavardsholm. Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial. RMD Open 2018;4(2):e000752. DOI:10.1136/rmdopen-2018-000752. The article is included in the thesis. Also available at https://doi.org/10.1136/rmdopen-2018-000752 https://doi.org/10.1002/art.40494 https://doi.org/10.1136/annrheumdis-2015-208873 https://doi.org/10.1136/rmdopen-2018-000752 http://urn.nb.no/URN:NBN:no-74172 http://hdl.handle.net/10852/71049 URN:NBN:no-74172 Fulltext https://www.duo.uio.no/bitstream/handle/10852/71049/1/PhD-Nordberg-2019.pdf Doctoral thesis Doktoravhandling 2019 ftoslouniv https://doi.org/10.1002/art.40494 https://doi.org/10.1136/annrheumdis-2015-208873 https://doi.org/10.1136/rmdopen-2018-000752 2020-06-21T08:54:11Z In this thesis Lena Bugge Nordberg assessed clinical aspects of new classification criteria and modern treatment for rheumatoid arthritis (RA). The thesis is based on data from the ARCTIC trial, in which 230 early RA patients were followed for 2 years. Nordberg examined whether the use of ultrasound, in addition to clinical examination, better identifies joints that will benefit from intra-articular glucocorticoid injections. The efficacy of injections was best if ultrasound showed active inflammation in the joint at the time of the injection. The findings support ultrasound as a tool for selection of joints for injection therapy. Nordberg also compared seropositive and seronegative patients fulfilling the new classification criteria for RA. At baseline, seronegative patients had markedly higher levels of joint inflammation than seropositive. After two years of treatment, disease outcomes were similar between groups. The findings suggest that patients now classified as seronegative RA have a more serious disease than before, and require intensive therapy. The results have also contributed to a discussion of the performance of the new classification criteria in seronegative patients. Doctoral or Postdoctoral Thesis Arctic Arctic Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Arctic Bugge ENVELOPE(-68.416,-68.416,-69.216,-69.216) Nordberg ENVELOPE(18.942,18.942,69.581,69.581) Arthritis & Rheumatology 70 8 1192 1199 |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
In this thesis Lena Bugge Nordberg assessed clinical aspects of new classification criteria and modern treatment for rheumatoid arthritis (RA). The thesis is based on data from the ARCTIC trial, in which 230 early RA patients were followed for 2 years. Nordberg examined whether the use of ultrasound, in addition to clinical examination, better identifies joints that will benefit from intra-articular glucocorticoid injections. The efficacy of injections was best if ultrasound showed active inflammation in the joint at the time of the injection. The findings support ultrasound as a tool for selection of joints for injection therapy. Nordberg also compared seropositive and seronegative patients fulfilling the new classification criteria for RA. At baseline, seronegative patients had markedly higher levels of joint inflammation than seropositive. After two years of treatment, disease outcomes were similar between groups. The findings suggest that patients now classified as seronegative RA have a more serious disease than before, and require intensive therapy. The results have also contributed to a discussion of the performance of the new classification criteria in seronegative patients. |
format |
Doctoral or Postdoctoral Thesis |
author |
Nordberg, Lena Bugge |
spellingShingle |
Nordberg, Lena Bugge Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies |
author_facet |
Nordberg, Lena Bugge |
author_sort |
Nordberg, Lena Bugge |
title |
Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies |
title_short |
Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies |
title_full |
Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies |
title_fullStr |
Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies |
title_full_unstemmed |
Early rheumatoid arthritis: Clinical aspects of new classification criteria and modern treatment strategies |
title_sort |
early rheumatoid arthritis: clinical aspects of new classification criteria and modern treatment strategies |
publishDate |
2019 |
url |
http://hdl.handle.net/10852/71049 http://urn.nb.no/URN:NBN:no-74172 |
long_lat |
ENVELOPE(-68.416,-68.416,-69.216,-69.216) ENVELOPE(18.942,18.942,69.581,69.581) |
geographic |
Arctic Bugge Nordberg |
geographic_facet |
Arctic Bugge Nordberg |
genre |
Arctic Arctic |
genre_facet |
Arctic Arctic |
op_relation |
Paper I: L. B. Nordberg, S. Lillegraven, A. B. Aga, J. Sexton, E. Lie, H.B. Hammer, I. C. Olsen, T. Uhlig, D. van der Heijde, T. K. Kvien, E. A. Haavardsholm. The impact of ultrasound on the use and efficacy of intra-articular glucocorticoid injections in early rheumatoid arthritis: Secondary analyses from a randomized trial examining the benefit of ultrasound in a clinical tight control regimen. Arthritis Rheumatol 2018;70(8):1192-9. DOI:10.1002/art.40494. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1002/art.40494 Paper II: L. B. Nordberg, S. Lillegraven, E. Lie, A. B. Aga, I. C. Olsen, H. B. Hammer, T. Uhlig, M. K. Jonsson, D. van der Heijde, T. K. Kvien, E. A. Haavardsholm and the ARCTIC working group. Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria. Annals of the Rheumatic Diseases 2017;76(2):341-5. DOI:10.1136/annrheumdis-2015-208873. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1136/annrheumdis-2015-208873 Paper III: L. B. Nordberg, S. Lillegraven, A. B. Aga, J. Sexton, I. C. Olsen, E. Lie, H. B. Hammer, T. Uhlig, D. van der Heijde, T. K. Kvien, E. A. Haavardsholm. Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial. RMD Open 2018;4(2):e000752. DOI:10.1136/rmdopen-2018-000752. The article is included in the thesis. Also available at https://doi.org/10.1136/rmdopen-2018-000752 https://doi.org/10.1002/art.40494 https://doi.org/10.1136/annrheumdis-2015-208873 https://doi.org/10.1136/rmdopen-2018-000752 http://urn.nb.no/URN:NBN:no-74172 http://hdl.handle.net/10852/71049 URN:NBN:no-74172 Fulltext https://www.duo.uio.no/bitstream/handle/10852/71049/1/PhD-Nordberg-2019.pdf |
op_doi |
https://doi.org/10.1002/art.40494 https://doi.org/10.1136/annrheumdis-2015-208873 https://doi.org/10.1136/rmdopen-2018-000752 |
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Arthritis & Rheumatology |
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