Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016
Aim: There is a lack of studies on frailty prevalence and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of this study was to investigate the associat...
Published in: | Geriatrics & Gerontology International |
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Blackwell Publishing
2018
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Online Access: | http://hdl.handle.net/10852/69185 http://urn.nb.no/URN:NBN:no-72335 https://doi.org/10.1111/ggi.13447 |
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ftoslouniv:oai:www.duo.uio.no:10852/69185 2023-05-15T18:34:28+02:00 Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter 2018-05-30T15:42:07Z http://hdl.handle.net/10852/69185 http://urn.nb.no/URN:NBN:no-72335 https://doi.org/10.1111/ggi.13447 EN eng Blackwell Publishing http://urn.nb.no/URN:NBN:no-72335 Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter . Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016. Geriatrics & Gerontology International. 2018, 18(8), 1200-1205 http://hdl.handle.net/10852/69185 1587836 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Geriatrics & Gerontology International&rft.volume=18&rft.spage=1200&rft.date=2018 Geriatrics & Gerontology International 18 8 1200 1205 http://dx.doi.org/10.1111/ggi.13447 URN:NBN:no-72335 Fulltext https://www.duo.uio.no/bitstream/handle/10852/69185/2/Accepted_manuscript_frailty.pdf 1444-1586 Journal article Tidsskriftartikkel Peer reviewed AcceptedVersion 2018 ftoslouniv https://doi.org/10.1111/ggi.13447 2020-06-21T08:52:48Z Aim: There is a lack of studies on frailty prevalence and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of this study was to investigate the association between the frailty phenotype and all-cause mortality in men and women in a Norwegian cohort study. Methods: We followed 712 participants (52% women) aged 70 years and older participating in the population-based Tromsø 5 Study in 2001-02 for all-cause mortality up to 2016. The frailty status at baseline was defined by a modified version of Fried’s frailty criteria. Cox regression models were used to analyze the association between frailty and mortality with adjustment for age, sex, disability, comorbidity, smoking status and years of education. Results: In total, 3.8% (n=27) of participants were frail (women: 4.4%, men: 3.2%) and 38.1% (n=271) were pre-frail (women: 45.8%, men: 29.9%). During follow-up (mean 10.1 years), 501 (70%) participants died. We found an increased risk of mortality for frail elderly (multivariateadjusted HR 4.16 (95% CI 2.40, 7.22)) compared to non-frail elderly. In sex-stratified analysis the adjusted HR was 7.09 (95% CI 3.03, 16.58) for frail men and 2.93 (95% CI 1.38, 6.22) for frail women. Results for pre-frailty showed an overall weaker association with mortality. Conclusions: While frailty was more prevalent in women than in men, the findings suggest that the association between frailty and mortality is stronger in men than in women. Article in Journal/Newspaper Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Tromsø Geriatrics & Gerontology International 18 8 1200 1205 |
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Open Polar |
collection |
Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
op_collection_id |
ftoslouniv |
language |
English |
description |
Aim: There is a lack of studies on frailty prevalence and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of this study was to investigate the association between the frailty phenotype and all-cause mortality in men and women in a Norwegian cohort study. Methods: We followed 712 participants (52% women) aged 70 years and older participating in the population-based Tromsø 5 Study in 2001-02 for all-cause mortality up to 2016. The frailty status at baseline was defined by a modified version of Fried’s frailty criteria. Cox regression models were used to analyze the association between frailty and mortality with adjustment for age, sex, disability, comorbidity, smoking status and years of education. Results: In total, 3.8% (n=27) of participants were frail (women: 4.4%, men: 3.2%) and 38.1% (n=271) were pre-frail (women: 45.8%, men: 29.9%). During follow-up (mean 10.1 years), 501 (70%) participants died. We found an increased risk of mortality for frail elderly (multivariateadjusted HR 4.16 (95% CI 2.40, 7.22)) compared to non-frail elderly. In sex-stratified analysis the adjusted HR was 7.09 (95% CI 3.03, 16.58) for frail men and 2.93 (95% CI 1.38, 6.22) for frail women. Results for pre-frailty showed an overall weaker association with mortality. Conclusions: While frailty was more prevalent in women than in men, the findings suggest that the association between frailty and mortality is stronger in men than in women. |
format |
Article in Journal/Newspaper |
author |
Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter |
spellingShingle |
Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
author_facet |
Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter |
author_sort |
Langholz, Petja |
title |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_short |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_full |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_fullStr |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_full_unstemmed |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_sort |
frailty phenotype and its association with all-cause mortality in community-dwelling norwegian women and men aged 70 years and older: the tromsø study 2001–2016 |
publisher |
Blackwell Publishing |
publishDate |
2018 |
url |
http://hdl.handle.net/10852/69185 http://urn.nb.no/URN:NBN:no-72335 https://doi.org/10.1111/ggi.13447 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
1444-1586 |
op_relation |
http://urn.nb.no/URN:NBN:no-72335 Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter . Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016. Geriatrics & Gerontology International. 2018, 18(8), 1200-1205 http://hdl.handle.net/10852/69185 1587836 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Geriatrics & Gerontology International&rft.volume=18&rft.spage=1200&rft.date=2018 Geriatrics & Gerontology International 18 8 1200 1205 http://dx.doi.org/10.1111/ggi.13447 URN:NBN:no-72335 Fulltext https://www.duo.uio.no/bitstream/handle/10852/69185/2/Accepted_manuscript_frailty.pdf |
op_doi |
https://doi.org/10.1111/ggi.13447 |
container_title |
Geriatrics & Gerontology International |
container_volume |
18 |
container_issue |
8 |
container_start_page |
1200 |
op_container_end_page |
1205 |
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1766219224720605184 |