Genomic characterization of the Atlantic cod sex-locus
A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence...
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ftoslouniv:oai:www.duo.uio.no:10852/61268 2023-05-15T15:26:50+02:00 Genomic characterization of the Atlantic cod sex-locus Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel 2016-08-26T20:37:59Z http://hdl.handle.net/10852/61268 http://urn.nb.no/URN:NBN:no-63882 https://doi.org/10.1038/srep31235 EN eng NFR/179569 NFR/221734 NFR/203850 NOTUR/NORSTORE/nn9244k http://urn.nb.no/URN:NBN:no-63882 Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel . Genomic characterization of the Atlantic cod sex-locus. Scientific Reports. 2016, 6, 1-9 http://hdl.handle.net/10852/61268 1375905 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=6&rft.spage=1&rft.date=2016 Scientific Reports 6 1 9 http://dx.doi.org/10.1038/srep31235 URN:NBN:no-63882 Fulltext https://www.duo.uio.no/bitstream/handle/10852/61268/1/sex_locus_srep31235.pdf Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ CC-BY 2045-2322 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2016 ftoslouniv https://doi.org/10.1038/srep31235 2020-06-21T08:51:47Z A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence (WGS) data of 227 wild-caught specimens. Analyzing more than 55 million polymorphic loci, we identify 166 loci that are associated with sex. These loci are located in six distinct regions on five different linkage groups (LG) in the genome. The largest of these regions, an approximately 55 Kb region on LG11, contains the majority of genotypes that segregate closely according to a XX-XY system. Genotypes in this region can be used genetically determine sex, whereas those in the other regions are inconsistently sex-linked. The identified region on LG11 and its surrounding genes have no clear sequence homology with genes or regulatory elements associated with sex-determination or differentiation in other species. The functionality of this sex-locus therefore remains unknown. The WGS strategy used here proved adequate for detecting the small regions associated with sex in this species. Our results highlight the evolutionary flexibility in genomic architecture underlying teleost sex-determination and allow practical applications to genetically sex Atlantic cod. Article in Journal/Newspaper atlantic cod Gadus morhua Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Scientific Reports 6 1 |
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Open Polar |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence (WGS) data of 227 wild-caught specimens. Analyzing more than 55 million polymorphic loci, we identify 166 loci that are associated with sex. These loci are located in six distinct regions on five different linkage groups (LG) in the genome. The largest of these regions, an approximately 55 Kb region on LG11, contains the majority of genotypes that segregate closely according to a XX-XY system. Genotypes in this region can be used genetically determine sex, whereas those in the other regions are inconsistently sex-linked. The identified region on LG11 and its surrounding genes have no clear sequence homology with genes or regulatory elements associated with sex-determination or differentiation in other species. The functionality of this sex-locus therefore remains unknown. The WGS strategy used here proved adequate for detecting the small regions associated with sex in this species. Our results highlight the evolutionary flexibility in genomic architecture underlying teleost sex-determination and allow practical applications to genetically sex Atlantic cod. |
format |
Article in Journal/Newspaper |
author |
Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel |
spellingShingle |
Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel Genomic characterization of the Atlantic cod sex-locus |
author_facet |
Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel |
author_sort |
Star, Bastiaan |
title |
Genomic characterization of the Atlantic cod sex-locus |
title_short |
Genomic characterization of the Atlantic cod sex-locus |
title_full |
Genomic characterization of the Atlantic cod sex-locus |
title_fullStr |
Genomic characterization of the Atlantic cod sex-locus |
title_full_unstemmed |
Genomic characterization of the Atlantic cod sex-locus |
title_sort |
genomic characterization of the atlantic cod sex-locus |
publishDate |
2016 |
url |
http://hdl.handle.net/10852/61268 http://urn.nb.no/URN:NBN:no-63882 https://doi.org/10.1038/srep31235 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
2045-2322 |
op_relation |
NFR/179569 NFR/221734 NFR/203850 NOTUR/NORSTORE/nn9244k http://urn.nb.no/URN:NBN:no-63882 Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel . Genomic characterization of the Atlantic cod sex-locus. Scientific Reports. 2016, 6, 1-9 http://hdl.handle.net/10852/61268 1375905 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=6&rft.spage=1&rft.date=2016 Scientific Reports 6 1 9 http://dx.doi.org/10.1038/srep31235 URN:NBN:no-63882 Fulltext https://www.duo.uio.no/bitstream/handle/10852/61268/1/sex_locus_srep31235.pdf |
op_rights |
Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/srep31235 |
container_title |
Scientific Reports |
container_volume |
6 |
container_issue |
1 |
_version_ |
1766357315340992512 |