The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study
Background Grip strength has consistently been found to predict all-cause mortality rates. However, few studies have examined cause-specific mortality or tested age differences in these associations. Methods In 1994, grip strength was measured in the population-based Tromsø Study, covering the ages...
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ftoslouniv:oai:www.duo.uio.no:10852/55177 2023-05-15T18:34:28+02:00 The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study Strand, Bjørn Heine Cooper, Rachel Bergland, Astrid Jørgensen, Lone Schirmer, Henrik Skirbekk, Vegard Emaus, Nina 2016-05-30T12:27:06Z http://hdl.handle.net/10852/55177 http://urn.nb.no/URN:NBN:no-57977 https://doi.org/10.1136/jech-2015-206776 EN eng BMJ Group http://urn.nb.no/URN:NBN:no-57977 Strand, Bjørn Heine Cooper, Rachel Bergland, Astrid Jørgensen, Lone Schirmer, Henrik Skirbekk, Vegard Emaus, Nina . The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study. Journal of Epidemiology and Community Health. 2016, 70(12), 1214-1221 http://hdl.handle.net/10852/55177 1358336 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Epidemiology and Community Health&rft.volume=70&rft.spage=1214&rft.date=2016 Journal of Epidemiology and Community Health 70 12 1214 1221 http://dx.doi.org/10.1136/jech-2015-206776 URN:NBN:no-57977 Fulltext https://www.duo.uio.no/bitstream/handle/10852/55177/1/Strand_2016_The.pdf Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ CC-BY 0143-005X Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2016 ftoslouniv https://doi.org/10.1136/jech-2015-206776 2020-06-21T08:50:18Z Background Grip strength has consistently been found to predict all-cause mortality rates. However, few studies have examined cause-specific mortality or tested age differences in these associations. Methods In 1994, grip strength was measured in the population-based Tromsø Study, covering the ages 50–80 years (N=6850). Grip strength was categorised into fifths, and as z-scores. In this cohort study, models with all-cause mortality and deaths from specific causes as the outcome were performed, stratified by sex and age using Cox regression, adjusting for lifestyle-related and health-related factors. Results During 17 years of follow-up, 2338 participants died. A 1 SD reduction in grip strength was associated with HR=1.17 (95% CI 1.12 to 1.22) for all-cause mortality in a model adjusted for age, gender and body size. This association was similar across all age groups, in men and women, and robust to adjustment for a range of lifestyle-related and health-related factors. Results for deaths due to cardiovascular disease (CVD), respiratory diseases and external causes resembled those for all-cause mortality, while for cancer, the association was much weaker and not significant after adjustment for lifestyle-related and health-related factors. Conclusions Weaker grip strength was associated with increased all-cause mortality rates, with similar effects on deaths due to CVD, respiratory disease and external causes, while a much weaker association was observed for cancer-related deaths. These associations were similar in both genders and across age groups, which supports the hypothesis that grip strength might be a biomarker of ageing over the lifespan. Article in Journal/Newspaper Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Tromsø Journal of Epidemiology and Community Health 70 12 1214 1221 |
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Open Polar |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
Background Grip strength has consistently been found to predict all-cause mortality rates. However, few studies have examined cause-specific mortality or tested age differences in these associations. Methods In 1994, grip strength was measured in the population-based Tromsø Study, covering the ages 50–80 years (N=6850). Grip strength was categorised into fifths, and as z-scores. In this cohort study, models with all-cause mortality and deaths from specific causes as the outcome were performed, stratified by sex and age using Cox regression, adjusting for lifestyle-related and health-related factors. Results During 17 years of follow-up, 2338 participants died. A 1 SD reduction in grip strength was associated with HR=1.17 (95% CI 1.12 to 1.22) for all-cause mortality in a model adjusted for age, gender and body size. This association was similar across all age groups, in men and women, and robust to adjustment for a range of lifestyle-related and health-related factors. Results for deaths due to cardiovascular disease (CVD), respiratory diseases and external causes resembled those for all-cause mortality, while for cancer, the association was much weaker and not significant after adjustment for lifestyle-related and health-related factors. Conclusions Weaker grip strength was associated with increased all-cause mortality rates, with similar effects on deaths due to CVD, respiratory disease and external causes, while a much weaker association was observed for cancer-related deaths. These associations were similar in both genders and across age groups, which supports the hypothesis that grip strength might be a biomarker of ageing over the lifespan. |
format |
Article in Journal/Newspaper |
author |
Strand, Bjørn Heine Cooper, Rachel Bergland, Astrid Jørgensen, Lone Schirmer, Henrik Skirbekk, Vegard Emaus, Nina |
spellingShingle |
Strand, Bjørn Heine Cooper, Rachel Bergland, Astrid Jørgensen, Lone Schirmer, Henrik Skirbekk, Vegard Emaus, Nina The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study |
author_facet |
Strand, Bjørn Heine Cooper, Rachel Bergland, Astrid Jørgensen, Lone Schirmer, Henrik Skirbekk, Vegard Emaus, Nina |
author_sort |
Strand, Bjørn Heine |
title |
The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study |
title_short |
The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study |
title_full |
The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study |
title_fullStr |
The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study |
title_full_unstemmed |
The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study |
title_sort |
association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the tromsø study |
publisher |
BMJ Group |
publishDate |
2016 |
url |
http://hdl.handle.net/10852/55177 http://urn.nb.no/URN:NBN:no-57977 https://doi.org/10.1136/jech-2015-206776 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
0143-005X |
op_relation |
http://urn.nb.no/URN:NBN:no-57977 Strand, Bjørn Heine Cooper, Rachel Bergland, Astrid Jørgensen, Lone Schirmer, Henrik Skirbekk, Vegard Emaus, Nina . The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study. Journal of Epidemiology and Community Health. 2016, 70(12), 1214-1221 http://hdl.handle.net/10852/55177 1358336 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Epidemiology and Community Health&rft.volume=70&rft.spage=1214&rft.date=2016 Journal of Epidemiology and Community Health 70 12 1214 1221 http://dx.doi.org/10.1136/jech-2015-206776 URN:NBN:no-57977 Fulltext https://www.duo.uio.no/bitstream/handle/10852/55177/1/Strand_2016_The.pdf |
op_rights |
Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1136/jech-2015-206776 |
container_title |
Journal of Epidemiology and Community Health |
container_volume |
70 |
container_issue |
12 |
container_start_page |
1214 |
op_container_end_page |
1221 |
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1766219217464459264 |