Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite
Background. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives. We hypothesized that chronic pain severity would be positively...
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ftoslouniv:oai:www.duo.uio.no:10852/51903 2023-05-15T18:34:38+02:00 Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite Sibille, Kimberly T Steingrímsdóttir, Ólöf Anna Fillingim, Roger B Stubhaug, Audun Schirmer, Henrik Chen, Huaihou McEwen, Bruce S Nielsen, Christopher Sivert 2016-08-19T12:43:11Z http://hdl.handle.net/10852/51903 http://urn.nb.no/URN:NBN:no-55329 https://doi.org/10.1155/2016/7657329 EN eng Pulsus Group Inc. http://urn.nb.no/URN:NBN:no-55329 Sibille, Kimberly T Steingrímsdóttir, Ólöf Anna Fillingim, Roger B Stubhaug, Audun Schirmer, Henrik Chen, Huaihou McEwen, Bruce S Nielsen, Christopher Sivert . Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite. Pain Research & Management. 2016, 2016 http://hdl.handle.net/10852/51903 1374143 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pain Research & Management&rft.volume=2016&rft.spage=&rft.date=2016 Pain Research & Management 2016 11 http://dx.doi.org/10.1155/2016/7657329 URN:NBN:no-55329 Fulltext https://www.duo.uio.no/bitstream/handle/10852/51903/2/Sibille_2016_Inv.pdf Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ CC-BY 1203-6765 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2016 ftoslouniv https://doi.org/10.1155/2016/7657329 2020-06-21T08:49:58Z Background. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives. We hypothesized that chronic pain severity would be positively associated with the risk factor composite. Methods. Data from 12,982 participants in the 6th Tromsø study were analyzed. Questionnaires included demographics, health behaviors, medical comorbidities, and chronic pain symptoms. The risk factor composite was comprised of body mass index, fibrinogen, C-reactive protein, and triglycerides. Chronic pain severity was characterized by frequency, intensity, time/duration, and total number of pain sites. Results. Individuals with chronic pain had a greater risk factor composite than individuals without chronic pain controlling for covariates and after excluding inflammation-related health conditions (). A significant “dose-response” relationship was demonstrated with pain severity (). In individuals with chronic pain, the risk factor composite varied by health behavior, exercise, lower levels and smoking, and higher levels. Discussion. The risk factor composite was higher in individuals with chronic pain, greater with increasing pain severity, and influenced by health behaviors. Conclusions. Identification of a biological composite sensitive to pain severity and adaptive/maladaptive behaviors would have significant clinical and research utility. Article in Journal/Newspaper Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Tromsø Pain Research and Management 2016 1 11 |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
Background. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives. We hypothesized that chronic pain severity would be positively associated with the risk factor composite. Methods. Data from 12,982 participants in the 6th Tromsø study were analyzed. Questionnaires included demographics, health behaviors, medical comorbidities, and chronic pain symptoms. The risk factor composite was comprised of body mass index, fibrinogen, C-reactive protein, and triglycerides. Chronic pain severity was characterized by frequency, intensity, time/duration, and total number of pain sites. Results. Individuals with chronic pain had a greater risk factor composite than individuals without chronic pain controlling for covariates and after excluding inflammation-related health conditions (). A significant “dose-response” relationship was demonstrated with pain severity (). In individuals with chronic pain, the risk factor composite varied by health behavior, exercise, lower levels and smoking, and higher levels. Discussion. The risk factor composite was higher in individuals with chronic pain, greater with increasing pain severity, and influenced by health behaviors. Conclusions. Identification of a biological composite sensitive to pain severity and adaptive/maladaptive behaviors would have significant clinical and research utility. |
format |
Article in Journal/Newspaper |
author |
Sibille, Kimberly T Steingrímsdóttir, Ólöf Anna Fillingim, Roger B Stubhaug, Audun Schirmer, Henrik Chen, Huaihou McEwen, Bruce S Nielsen, Christopher Sivert |
spellingShingle |
Sibille, Kimberly T Steingrímsdóttir, Ólöf Anna Fillingim, Roger B Stubhaug, Audun Schirmer, Henrik Chen, Huaihou McEwen, Bruce S Nielsen, Christopher Sivert Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
author_facet |
Sibille, Kimberly T Steingrímsdóttir, Ólöf Anna Fillingim, Roger B Stubhaug, Audun Schirmer, Henrik Chen, Huaihou McEwen, Bruce S Nielsen, Christopher Sivert |
author_sort |
Sibille, Kimberly T |
title |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_short |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_full |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_fullStr |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_full_unstemmed |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_sort |
investigating the burden of chronic pain: an inflammatory and metabolic composite |
publisher |
Pulsus Group Inc. |
publishDate |
2016 |
url |
http://hdl.handle.net/10852/51903 http://urn.nb.no/URN:NBN:no-55329 https://doi.org/10.1155/2016/7657329 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
1203-6765 |
op_relation |
http://urn.nb.no/URN:NBN:no-55329 Sibille, Kimberly T Steingrímsdóttir, Ólöf Anna Fillingim, Roger B Stubhaug, Audun Schirmer, Henrik Chen, Huaihou McEwen, Bruce S Nielsen, Christopher Sivert . Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite. Pain Research & Management. 2016, 2016 http://hdl.handle.net/10852/51903 1374143 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pain Research & Management&rft.volume=2016&rft.spage=&rft.date=2016 Pain Research & Management 2016 11 http://dx.doi.org/10.1155/2016/7657329 URN:NBN:no-55329 Fulltext https://www.duo.uio.no/bitstream/handle/10852/51903/2/Sibille_2016_Inv.pdf |
op_rights |
Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1155/2016/7657329 |
container_title |
Pain Research and Management |
container_volume |
2016 |
container_start_page |
1 |
op_container_end_page |
11 |
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1766219475048202240 |