Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon
Background Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, Lepeophtheirus salmonis. However, the mechanisms involved in differential response to infection remain poorly understood. Recent findings in Atlantic salmon (Salmo salar) have pr...
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ftoslouniv:oai:www.duo.uio.no:10852/46533 2023-05-15T15:31:41+02:00 Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon Gharbi, Karim Glover, Kevin A Stone, Louise C MacDonald, Elizabeth S Matthews, Louise Grimholt, Unni Stear, Michael J 2009 http://hdl.handle.net/10852/46533 http://urn.nb.no/URN:NBN:no-50710 https://doi.org/10.1186/1471-2156-10-20 eng eng http://urn.nb.no/URN:NBN:no-50710 BMC Genetics. 2009 Apr 27;10(1):20 http://hdl.handle.net/10852/46533 http://dx.doi.org/10.1186/1471-2156-10-20 URN:NBN:no-50710 Fulltext https://www.duo.uio.no/bitstream/handle/10852/46533/1/12863_2008_Article_678.pdf Gharbi et al. Attribution 2.0 Generic http://creativecommons.org/licenses/by/2.0/ CC-BY Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2009 ftoslouniv https://doi.org/10.1186/1471-2156-10-20 2020-06-21T08:48:52Z Background Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, Lepeophtheirus salmonis. However, the mechanisms involved in differential response to infection remain poorly understood. Recent findings in Atlantic salmon (Salmo salar) have provided evidence for a potential link between marker variation at the major histocompatibility complex (MHC) and differences in lice abundance among infected siblings, suggesting that MHC genes can modulate susceptibility to the parasite. In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively. Results Significant QTL effects were detected on both LG 6 and LG 15 in sire-based analysis but the QTL regions remained unresolved due to a lack of recombination between markers. In dam-based analysis, a significant QTL was identified on LG 6, which accounted for 12.9% of within-family variance in lice abundance. However, the QTL was located at the opposite end of DAA, with no significant overlap with the MHC class II region. Interestingly, QTL modelling also revealed evidence of sex-linked differences in lice abundance, indicating that males and females may have different susceptibility to infection. Conclusion Overall, QTL analysis provided relatively weak support for a proximal effect of classical MHC regions on lice abundance, which can partly be explained by linkage to other genes controlling susceptibility to L. salmonis on the same chromosome. Article in Journal/Newspaper Atlantic salmon Salmo salar Universitet i Oslo: Digitale utgivelser ved UiO (DUO) BMC Genetics 10 1 |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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language |
English |
description |
Background Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, Lepeophtheirus salmonis. However, the mechanisms involved in differential response to infection remain poorly understood. Recent findings in Atlantic salmon (Salmo salar) have provided evidence for a potential link between marker variation at the major histocompatibility complex (MHC) and differences in lice abundance among infected siblings, suggesting that MHC genes can modulate susceptibility to the parasite. In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively. Results Significant QTL effects were detected on both LG 6 and LG 15 in sire-based analysis but the QTL regions remained unresolved due to a lack of recombination between markers. In dam-based analysis, a significant QTL was identified on LG 6, which accounted for 12.9% of within-family variance in lice abundance. However, the QTL was located at the opposite end of DAA, with no significant overlap with the MHC class II region. Interestingly, QTL modelling also revealed evidence of sex-linked differences in lice abundance, indicating that males and females may have different susceptibility to infection. Conclusion Overall, QTL analysis provided relatively weak support for a proximal effect of classical MHC regions on lice abundance, which can partly be explained by linkage to other genes controlling susceptibility to L. salmonis on the same chromosome. |
format |
Article in Journal/Newspaper |
author |
Gharbi, Karim Glover, Kevin A Stone, Louise C MacDonald, Elizabeth S Matthews, Louise Grimholt, Unni Stear, Michael J |
spellingShingle |
Gharbi, Karim Glover, Kevin A Stone, Louise C MacDonald, Elizabeth S Matthews, Louise Grimholt, Unni Stear, Michael J Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon |
author_facet |
Gharbi, Karim Glover, Kevin A Stone, Louise C MacDonald, Elizabeth S Matthews, Louise Grimholt, Unni Stear, Michael J |
author_sort |
Gharbi, Karim |
title |
Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon |
title_short |
Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon |
title_full |
Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon |
title_fullStr |
Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon |
title_full_unstemmed |
Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon |
title_sort |
genetic dissection of mhc-associated susceptibility to lepeophtheirus salmonis in atlantic salmon |
publishDate |
2009 |
url |
http://hdl.handle.net/10852/46533 http://urn.nb.no/URN:NBN:no-50710 https://doi.org/10.1186/1471-2156-10-20 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://urn.nb.no/URN:NBN:no-50710 BMC Genetics. 2009 Apr 27;10(1):20 http://hdl.handle.net/10852/46533 http://dx.doi.org/10.1186/1471-2156-10-20 URN:NBN:no-50710 Fulltext https://www.duo.uio.no/bitstream/handle/10852/46533/1/12863_2008_Article_678.pdf |
op_rights |
Gharbi et al. Attribution 2.0 Generic http://creativecommons.org/licenses/by/2.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/1471-2156-10-20 |
container_title |
BMC Genetics |
container_volume |
10 |
container_issue |
1 |
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1766362204329738240 |