Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia
DESIGN: Strains isolated from 119 patients with pulmonary tuberculosis were studied by the BACTEC method. Medical records of the patients were reviewed, retrospectively, to identify factors associated with drug resistance. RESULTS: Sixty-seven strains (56.3%) were resistant to at least one antituber...
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ftoslouniv:oai:www.duo.uio.no:10852/30090 2023-05-15T15:23:35+02:00 Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia Toungoussova, Olga Gunnar Bjune, Dominique A. Caugant, Per Sandven, Andrey Mariandyshev 2001 http://hdl.handle.net/10852/30090 http://urn.nb.no/URN:NBN:no-9599 eng eng http://urn.nb.no/URN:NBN:no-9599 Toungoussova, Olga. Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia. Masteroppgave, University of Oslo, 2001 http://hdl.handle.net/10852/30090 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Toungoussova, Olga&rft.title=Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia&rft.inst=University of Oslo&rft.date=2001&rft.degree=Masteroppgave URN:NBN:no-9599 20659 041699831 Fulltext https://www.duo.uio.no/bitstream/handle/10852/30090/1/toungoussova.pdf VDP::751 Master thesis Masteroppgave 2001 ftoslouniv 2020-06-21T08:45:42Z DESIGN: Strains isolated from 119 patients with pulmonary tuberculosis were studied by the BACTEC method. Medical records of the patients were reviewed, retrospectively, to identify factors associated with drug resistance. RESULTS: Sixty-seven strains (56.3%) were resistant to at least one antituberculosis drug. Thirty of the 119 strains (25.2%) were multi-drug resistant. All strains resistant to rifampicin were multi-drug resistant. Multidrug resistance was four times more common among previously treated patients than among new patients. The highest rates of drug resistance were observed for streptomycin and isoniazid. 40.4% and 66.7% of strains collected from new and previously treated patients were resistant to streptomycin, respectively. 37.1% and 73.3% of strains collected from new and previously treated patients were resistant to isoniazid, respectively. A history of previous or interrupted treatment for tuberculosis and being female were significantly associated with resistance to at least one anti-tuberculosis drug and multidrug resistance. CONCLUSION: Drug-resistant tuberculosis is an important problem in the Arkhangelsk oblast, Russia. The spread of drug-resistant strains of M. tuberculosis is attributed to several risk factors. A history of previous or interrupted treatment for tuberculosis and being female are significantly associated with resistance to at least one anti-tuberculosis drug and multidrug resistance. Employment in the health sector of Arkhangelsk was significantly associated with the development of drug resistance. Master Thesis Arkhangelsk Arkhangelsk Oblast Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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English |
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VDP::751 Toungoussova, Olga Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia |
topic_facet |
VDP::751 |
description |
DESIGN: Strains isolated from 119 patients with pulmonary tuberculosis were studied by the BACTEC method. Medical records of the patients were reviewed, retrospectively, to identify factors associated with drug resistance. RESULTS: Sixty-seven strains (56.3%) were resistant to at least one antituberculosis drug. Thirty of the 119 strains (25.2%) were multi-drug resistant. All strains resistant to rifampicin were multi-drug resistant. Multidrug resistance was four times more common among previously treated patients than among new patients. The highest rates of drug resistance were observed for streptomycin and isoniazid. 40.4% and 66.7% of strains collected from new and previously treated patients were resistant to streptomycin, respectively. 37.1% and 73.3% of strains collected from new and previously treated patients were resistant to isoniazid, respectively. A history of previous or interrupted treatment for tuberculosis and being female were significantly associated with resistance to at least one anti-tuberculosis drug and multidrug resistance. CONCLUSION: Drug-resistant tuberculosis is an important problem in the Arkhangelsk oblast, Russia. The spread of drug-resistant strains of M. tuberculosis is attributed to several risk factors. A history of previous or interrupted treatment for tuberculosis and being female are significantly associated with resistance to at least one anti-tuberculosis drug and multidrug resistance. Employment in the health sector of Arkhangelsk was significantly associated with the development of drug resistance. |
author2 |
Gunnar Bjune, Dominique A. Caugant, Per Sandven, Andrey Mariandyshev |
format |
Master Thesis |
author |
Toungoussova, Olga |
author_facet |
Toungoussova, Olga |
author_sort |
Toungoussova, Olga |
title |
Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia |
title_short |
Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia |
title_full |
Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia |
title_fullStr |
Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia |
title_full_unstemmed |
Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia |
title_sort |
determination of risk factors for the development of tuberculosis with drug-resistant strains of mycobacterium tuberculosis in the arkhangelsk oblast, russia |
publishDate |
2001 |
url |
http://hdl.handle.net/10852/30090 http://urn.nb.no/URN:NBN:no-9599 |
genre |
Arkhangelsk Arkhangelsk Oblast |
genre_facet |
Arkhangelsk Arkhangelsk Oblast |
op_relation |
http://urn.nb.no/URN:NBN:no-9599 Toungoussova, Olga. Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia. Masteroppgave, University of Oslo, 2001 http://hdl.handle.net/10852/30090 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Toungoussova, Olga&rft.title=Determination of risk factors for the development of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in the Arkhangelsk oblast, Russia&rft.inst=University of Oslo&rft.date=2001&rft.degree=Masteroppgave URN:NBN:no-9599 20659 041699831 Fulltext https://www.duo.uio.no/bitstream/handle/10852/30090/1/toungoussova.pdf |
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1766354251719639040 |