Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation
peer reviewed Physiologically based pharmacokinetic (PBPK) models were developed for the most persistent polychlorinated biphenyl (PCB 153) in male and female harbor porpoises (Phocoena phocoena) to elucidate processes such as uptake, distribution, and elimination. Due to its limited metabolic capac...
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Online Access: | https://orbi.uliege.be/handle/2268/72535 https://doi.org/10.1021/es101688h |
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ftorbi:oai:orbi.ulg.ac.be:2268/72535 2024-04-21T08:10:26+00:00 Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation Weijs, Liesbeth Yang, Raymond Covaci, Adrian Das, Krishna Blust, Ronny 2010 https://orbi.uliege.be/handle/2268/72535 https://doi.org/10.1021/es101688h en eng American Chemical Society urn:issn:0013-936X urn:issn:1520-5851 https://orbi.uliege.be/handle/2268/72535 info:hdl:2268/72535 doi:10.1021/es101688h scopus-id:2-s2.0-77956555217 info:pmid:20718467 restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess Environmental Science and Technology, 44, 7023–7030 (2010) Phocoena phocoena Physiologically based pharmacokinetic models pollutants PCB 153 Life sciences Environmental sciences & ecology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Sciences aquatiques & océanologie journal article http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/article peer reviewed 2010 ftorbi https://doi.org/10.1021/es101688h 2024-03-27T14:52:34Z peer reviewed Physiologically based pharmacokinetic (PBPK) models were developed for the most persistent polychlorinated biphenyl (PCB 153) in male and female harbor porpoises (Phocoena phocoena) to elucidate processes such as uptake, distribution, and elimination. Due to its limited metabolic capacities, long life span, and top position in marine food chains, this species is highly sensitive to pollution. The models consist of 5 compartments, liver, blubber, kidney, brain, and a compartment which accounts for the rest of the body, all connected through blood. All physiological and biochemical parameters were extracted from the literature, except for the brain/blood partition coefficient and rate of excretion, which were both fitted to data sets used for validation of the models. These data sets were compiled from our own analyses performed with GCMS on tissue samples of harbor porpoises. The intake of PCB 153 was from milk from birth to 4 months, and after weaning fish was the main food source. Overall, these models reveal that concentrations of PCB 153 in males increase with age but suggest that,asthe animalsgrowolder, metabolic transformation can be a possible pathway for elimination as well. In contrast, the model for females confirms that gestation and lactation are key processes for eliminating PCB 153 as body burdens decrease with age. These PBPK models are capable of simulating the bioaccumulation of PCB 153 during the entire life span of approximately 20 years of the harbor porpoises. Article in Journal/Newspaper Phocoena phocoena University of Liège: ORBi (Open Repository and Bibliography) Environmental Science & Technology 44 18 7023 7030 |
institution |
Open Polar |
collection |
University of Liège: ORBi (Open Repository and Bibliography) |
op_collection_id |
ftorbi |
language |
English |
topic |
Phocoena phocoena Physiologically based pharmacokinetic models pollutants PCB 153 Life sciences Environmental sciences & ecology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Sciences aquatiques & océanologie |
spellingShingle |
Phocoena phocoena Physiologically based pharmacokinetic models pollutants PCB 153 Life sciences Environmental sciences & ecology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Sciences aquatiques & océanologie Weijs, Liesbeth Yang, Raymond Covaci, Adrian Das, Krishna Blust, Ronny Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation |
topic_facet |
Phocoena phocoena Physiologically based pharmacokinetic models pollutants PCB 153 Life sciences Environmental sciences & ecology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Sciences aquatiques & océanologie |
description |
peer reviewed Physiologically based pharmacokinetic (PBPK) models were developed for the most persistent polychlorinated biphenyl (PCB 153) in male and female harbor porpoises (Phocoena phocoena) to elucidate processes such as uptake, distribution, and elimination. Due to its limited metabolic capacities, long life span, and top position in marine food chains, this species is highly sensitive to pollution. The models consist of 5 compartments, liver, blubber, kidney, brain, and a compartment which accounts for the rest of the body, all connected through blood. All physiological and biochemical parameters were extracted from the literature, except for the brain/blood partition coefficient and rate of excretion, which were both fitted to data sets used for validation of the models. These data sets were compiled from our own analyses performed with GCMS on tissue samples of harbor porpoises. The intake of PCB 153 was from milk from birth to 4 months, and after weaning fish was the main food source. Overall, these models reveal that concentrations of PCB 153 in males increase with age but suggest that,asthe animalsgrowolder, metabolic transformation can be a possible pathway for elimination as well. In contrast, the model for females confirms that gestation and lactation are key processes for eliminating PCB 153 as body burdens decrease with age. These PBPK models are capable of simulating the bioaccumulation of PCB 153 during the entire life span of approximately 20 years of the harbor porpoises. |
format |
Article in Journal/Newspaper |
author |
Weijs, Liesbeth Yang, Raymond Covaci, Adrian Das, Krishna Blust, Ronny |
author_facet |
Weijs, Liesbeth Yang, Raymond Covaci, Adrian Das, Krishna Blust, Ronny |
author_sort |
Weijs, Liesbeth |
title |
Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation |
title_short |
Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation |
title_full |
Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation |
title_fullStr |
Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation |
title_full_unstemmed |
Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation |
title_sort |
physiologically based pharmacokinetic (pbpk) models for lifetime exposure to pcb 153 in male and female harbor porpoises (phocoena phocoena): model development and evaluation |
publisher |
American Chemical Society |
publishDate |
2010 |
url |
https://orbi.uliege.be/handle/2268/72535 https://doi.org/10.1021/es101688h |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_source |
Environmental Science and Technology, 44, 7023–7030 (2010) |
op_relation |
urn:issn:0013-936X urn:issn:1520-5851 https://orbi.uliege.be/handle/2268/72535 info:hdl:2268/72535 doi:10.1021/es101688h scopus-id:2-s2.0-77956555217 info:pmid:20718467 |
op_rights |
restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1021/es101688h |
container_title |
Environmental Science & Technology |
container_volume |
44 |
container_issue |
18 |
container_start_page |
7023 |
op_container_end_page |
7030 |
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1796951893875884032 |