Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects?
peer reviewed Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which accumulate in tissues of harbor seals. POPs and trace elements can negatively affect...
Published in: | Archives of Environmental Contamination and Toxicology |
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Springer Science & Business Media B.V.
2016
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Online Access: | https://orbi.uliege.be/handle/2268/185212 https://doi.org/10.1007/s00244-015-0202-3 |
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ftorbi:oai:orbi.ulg.ac.be:2268/185212 2024-04-21T08:10:25+00:00 Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects? Lehnert, Kristina Ronnenberg, Katrin Weijs, Liesbeth Covaci, Adrian Das, Krishna Hellwig, Veronika Siebert, Ursula MARE - Centre Interfacultaire de Recherches en Océanologie - ULiège 2016-01 https://orbi.uliege.be/handle/2268/185212 https://doi.org/10.1007/s00244-015-0202-3 en eng Springer Science & Business Media B.V. urn:issn:0090-4341 urn:issn:1432-0703 https://orbi.uliege.be/handle/2268/185212 info:hdl:2268/185212 doi:10.1007/s00244-015-0202-3 scopus-id:2-s2.0-84958123947 info:pmid:26296438 restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess Archives of Environmental Contamination and Toxicology, 70 (1), 106-120 (2016-01) marine mammals seals pollutants biomarkers Phoca vitulina Life sciences Environmental sciences & ecology Anatomy (cytology histology embryology.) & physiology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Anatomie (cytologie histologie embryologie.) & physiologie Sciences aquatiques & océanologie journal article http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/article peer reviewed 2016 ftorbi https://doi.org/10.1007/s00244-015-0202-3 2024-03-27T14:52:50Z peer reviewed Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which accumulate in tissues of harbor seals. POPs and trace elements can negatively affect the immune-system and have been reported e.g. to increase susceptibility to viral infections in seals. Biomarkers of the xenobiotic metabolism, cytokines and heat-shock-protein as cell mediators of the immune-system were established to evaluate the impact of environmental stressors on harbor seals. Harbor seals (n=54) were captured on sandbanks in the North Sea during 2009 to 2012. Medicals including hematology were performed, RNAlater blood samples were taken and analyzed using quantitative Polymerase Chain Reaction. Normalized transcript copy numbers were correlated to hematology and POP concentration in blood, and trace metals in blood and fur. Article in Journal/Newspaper Phoca vitulina University of Liège: ORBi (Open Repository and Bibliography) Archives of Environmental Contamination and Toxicology 70 1 106 120 |
institution |
Open Polar |
collection |
University of Liège: ORBi (Open Repository and Bibliography) |
op_collection_id |
ftorbi |
language |
English |
topic |
marine mammals seals pollutants biomarkers Phoca vitulina Life sciences Environmental sciences & ecology Anatomy (cytology histology embryology.) & physiology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Anatomie (cytologie histologie embryologie.) & physiologie Sciences aquatiques & océanologie |
spellingShingle |
marine mammals seals pollutants biomarkers Phoca vitulina Life sciences Environmental sciences & ecology Anatomy (cytology histology embryology.) & physiology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Anatomie (cytologie histologie embryologie.) & physiologie Sciences aquatiques & océanologie Lehnert, Kristina Ronnenberg, Katrin Weijs, Liesbeth Covaci, Adrian Das, Krishna Hellwig, Veronika Siebert, Ursula Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects? |
topic_facet |
marine mammals seals pollutants biomarkers Phoca vitulina Life sciences Environmental sciences & ecology Anatomy (cytology histology embryology.) & physiology Aquatic sciences & oceanology Sciences du vivant Sciences de l’environnement & écologie Anatomie (cytologie histologie embryologie.) & physiologie Sciences aquatiques & océanologie |
description |
peer reviewed Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which accumulate in tissues of harbor seals. POPs and trace elements can negatively affect the immune-system and have been reported e.g. to increase susceptibility to viral infections in seals. Biomarkers of the xenobiotic metabolism, cytokines and heat-shock-protein as cell mediators of the immune-system were established to evaluate the impact of environmental stressors on harbor seals. Harbor seals (n=54) were captured on sandbanks in the North Sea during 2009 to 2012. Medicals including hematology were performed, RNAlater blood samples were taken and analyzed using quantitative Polymerase Chain Reaction. Normalized transcript copy numbers were correlated to hematology and POP concentration in blood, and trace metals in blood and fur. |
author2 |
MARE - Centre Interfacultaire de Recherches en Océanologie - ULiège |
format |
Article in Journal/Newspaper |
author |
Lehnert, Kristina Ronnenberg, Katrin Weijs, Liesbeth Covaci, Adrian Das, Krishna Hellwig, Veronika Siebert, Ursula |
author_facet |
Lehnert, Kristina Ronnenberg, Katrin Weijs, Liesbeth Covaci, Adrian Das, Krishna Hellwig, Veronika Siebert, Ursula |
author_sort |
Lehnert, Kristina |
title |
Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects? |
title_short |
Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects? |
title_full |
Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects? |
title_fullStr |
Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects? |
title_full_unstemmed |
Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects? |
title_sort |
xenobiotic and immune-relevant molecular biomarkers in harbor seals as proxies for pollutant burden and effects? |
publisher |
Springer Science & Business Media B.V. |
publishDate |
2016 |
url |
https://orbi.uliege.be/handle/2268/185212 https://doi.org/10.1007/s00244-015-0202-3 |
genre |
Phoca vitulina |
genre_facet |
Phoca vitulina |
op_source |
Archives of Environmental Contamination and Toxicology, 70 (1), 106-120 (2016-01) |
op_relation |
urn:issn:0090-4341 urn:issn:1432-0703 https://orbi.uliege.be/handle/2268/185212 info:hdl:2268/185212 doi:10.1007/s00244-015-0202-3 scopus-id:2-s2.0-84958123947 info:pmid:26296438 |
op_rights |
restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1007/s00244-015-0202-3 |
container_title |
Archives of Environmental Contamination and Toxicology |
container_volume |
70 |
container_issue |
1 |
container_start_page |
106 |
op_container_end_page |
120 |
_version_ |
1796951870816649216 |