Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology
peer reviewed Physiologically based pharmacokinetic (PBPK) models are mathematical models that are largely based upon the physiological characteristics of the species and the biochemical properties of the chemical of interest. They quantitatively describe and predict the kinetics of pollutants insid...
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ftorbi:oai:orbi.ulg.ac.be:2268/133885 2024-04-21T08:04:12+00:00 Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology Weijs, Liesbeth Yang, Raymond S.H. Das, Krishna Blust, Ronny Covaci, Adrian 2012 https://orbi.uliege.be/handle/2268/133885 https://orbi.uliege.be/bitstream/2268/133885/1/2012%20Weijs%20PBPK.pdf en eng Terrapub https://orbi.uliege.be/handle/2268/133885 info:hdl:2268/133885 https://orbi.uliege.be/bitstream/2268/133885/1/2012%20Weijs%20PBPK.pdf open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Interdisciplinary Studies on Environmental Chemistry—Environmental Pollution and Ecotoxicology, 67-72 (2012); Interdisciplinary Studies on Environmental Chemistry, Japan [JP], 2011 marine mammals pollutants PBPK models physiologically based pharmakinetic models PCBs PBDEs spatial trends temporal trends harbour porpoise Life sciences Aquatic sciences & oceanology Sciences du vivant Sciences aquatiques & océanologie conference paper http://purl.org/coar/resource_type/c_5794 info:eu-repo/semantics/conferenceObject peer reviewed 2012 ftorbi 2024-03-27T14:44:48Z peer reviewed Physiologically based pharmacokinetic (PBPK) models are mathematical models that are largely based upon the physiological characteristics of the species and the biochemical properties of the chemical of interest. They quantitatively describe and predict the kinetics of pollutants inside the body and can be of major importance for risk assessment of chemicals in marine mammals. PBPK models which consist of five compartments (liver, blubber, kidney, brain, and the rest of the body) were made for selected polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in order to address the bioaccumulation of these compounds in tissues of harbour porpoises (Phocoena phocoena). Harbour porpoises have relatively long life spans, are common cetaceans in the North Sea, a heavily polluted area, and are known to be very sensitive to pollution. Models developed for all compounds (some PCBs and PBDEs) were evaluated using existing datasets from the literature and from analyses performed by GC-MS, the latter being obtained from stranded porpoises in the Black Sea and the North Sea over a period of 18 years (1990–2008) to assess spatial and temporal trends in bioaccumulation of the respective PCBs and PBDEs. We demonstrate that PBPK models are a feasible computational approach that can be used as a non-destructive tool for predicting the chemical pollution status of the marine mammals. Conference Object Harbour porpoise Phocoena phocoena University of Liège: ORBi (Open Repository and Bibliography) |
institution |
Open Polar |
collection |
University of Liège: ORBi (Open Repository and Bibliography) |
op_collection_id |
ftorbi |
language |
English |
topic |
marine mammals pollutants PBPK models physiologically based pharmakinetic models PCBs PBDEs spatial trends temporal trends harbour porpoise Life sciences Aquatic sciences & oceanology Sciences du vivant Sciences aquatiques & océanologie |
spellingShingle |
marine mammals pollutants PBPK models physiologically based pharmakinetic models PCBs PBDEs spatial trends temporal trends harbour porpoise Life sciences Aquatic sciences & oceanology Sciences du vivant Sciences aquatiques & océanologie Weijs, Liesbeth Yang, Raymond S.H. Das, Krishna Blust, Ronny Covaci, Adrian Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology |
topic_facet |
marine mammals pollutants PBPK models physiologically based pharmakinetic models PCBs PBDEs spatial trends temporal trends harbour porpoise Life sciences Aquatic sciences & oceanology Sciences du vivant Sciences aquatiques & océanologie |
description |
peer reviewed Physiologically based pharmacokinetic (PBPK) models are mathematical models that are largely based upon the physiological characteristics of the species and the biochemical properties of the chemical of interest. They quantitatively describe and predict the kinetics of pollutants inside the body and can be of major importance for risk assessment of chemicals in marine mammals. PBPK models which consist of five compartments (liver, blubber, kidney, brain, and the rest of the body) were made for selected polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in order to address the bioaccumulation of these compounds in tissues of harbour porpoises (Phocoena phocoena). Harbour porpoises have relatively long life spans, are common cetaceans in the North Sea, a heavily polluted area, and are known to be very sensitive to pollution. Models developed for all compounds (some PCBs and PBDEs) were evaluated using existing datasets from the literature and from analyses performed by GC-MS, the latter being obtained from stranded porpoises in the Black Sea and the North Sea over a period of 18 years (1990–2008) to assess spatial and temporal trends in bioaccumulation of the respective PCBs and PBDEs. We demonstrate that PBPK models are a feasible computational approach that can be used as a non-destructive tool for predicting the chemical pollution status of the marine mammals. |
format |
Conference Object |
author |
Weijs, Liesbeth Yang, Raymond S.H. Das, Krishna Blust, Ronny Covaci, Adrian |
author_facet |
Weijs, Liesbeth Yang, Raymond S.H. Das, Krishna Blust, Ronny Covaci, Adrian |
author_sort |
Weijs, Liesbeth |
title |
Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology |
title_short |
Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology |
title_full |
Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology |
title_fullStr |
Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology |
title_full_unstemmed |
Use of Physiologically Based Pharmacokinetic (PBPK) Models in Marine Mammal Toxicology |
title_sort |
use of physiologically based pharmacokinetic (pbpk) models in marine mammal toxicology |
publisher |
Terrapub |
publishDate |
2012 |
url |
https://orbi.uliege.be/handle/2268/133885 https://orbi.uliege.be/bitstream/2268/133885/1/2012%20Weijs%20PBPK.pdf |
genre |
Harbour porpoise Phocoena phocoena |
genre_facet |
Harbour porpoise Phocoena phocoena |
op_source |
Interdisciplinary Studies on Environmental Chemistry—Environmental Pollution and Ecotoxicology, 67-72 (2012); Interdisciplinary Studies on Environmental Chemistry, Japan [JP], 2011 |
op_relation |
https://orbi.uliege.be/handle/2268/133885 info:hdl:2268/133885 https://orbi.uliege.be/bitstream/2268/133885/1/2012%20Weijs%20PBPK.pdf |
op_rights |
open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
_version_ |
1796943846232293376 |