Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis
Background. Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by high rates of co-morbid psychopathology. Randomized controlled trials of multimodal interventions, combining pharmacological and psychological treatments, have shown a robust treatment effec...
Published in: | Psychological Medicine |
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Cambridge University Press (CUP)
2015
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Online Access: | https://hdl.handle.net/20.500.11815/921 https://doi.org/10.1017/S0033291715000756 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/921 2023-05-15T16:49:37+02:00 Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis Young, Susan Khondoker, Mizanur Emilsson, B. Sigurdsson, Jon Fridrik Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, H. Gudjonsson, G. Viðskiptadeild (HR) School of Business (RU) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskólinn í Reykjavík (HR) Reykjavík University (RU) Háskóli Íslands (HÍ) University of Iceland (UI) 2015-05-29 2793-2804 https://hdl.handle.net/20.500.11815/921 https://doi.org/10.1017/S0033291715000756 en eng Cambridge University Press (CUP) Psychological Medicine;45(13) https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0033291715000756 Young, S., Khondoker, M., Emilsson, B., Sigurdsson, J. F., Philipp-Wiegmann, F., Baldursson, G., … Gudjonsson, G. (2015). Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. Psychological Medicine, 45(13), 2793–2804. https://doi.org/10.1017/S0033291715000756 0033-2917 1469-8978( eISSN) https://hdl.handle.net/20.500.11815/921 Psychological Medicine doi:10.1017/S0033291715000756 info:eu-repo/semantics/openAccess Attention-deficit/hyperactivity disorder Cognitive behavioural therapy Randomized controlled trials Reasoning and rehabilitation R & R2 Treatment Meðferð Atferlismeðferð Psychology Sálfræði info:eu-repo/semantics/article 2015 ftopinvisindi https://doi.org/20.500.11815/921 https://doi.org/10.1017/S0033291715000756 2022-11-18T06:51:41Z Background. Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by high rates of co-morbid psychopathology. Randomized controlled trials of multimodal interventions, combining pharmacological and psychological treatments, have shown a robust treatment effect for ADHD symptoms but outcomes for co-morbid symptoms have been mixed. This may be accounted for by the type of intervention selected and/or by methodological problems including lack of follow-up and low power. The current study addressed these limitations in a parallel-group randomized controlled trial conducted in Iceland. Method. A total of 95 adult ADHD patients who were already being treated with medication (MED) were randomly assigned to receive treatment as usual (TAU/MED) or 15 sessions of cognitive–behavioural therapy (CBT/MED) using the R&R2ADHD intervention which employs both group and individual modalities. Primary measures of ADHD symptoms and severity of illness, and secondary measures of anxiety, depression and quality of life were given at baseline, end of treatment and 3-month follow-up. Primary outcomes were rated by clinicians blind to treatment condition assignment. Results. CBT/MED showed overall (combined outcome at end of treatment and 3-month follow-up) significantly greater reduction in primary outcomes for clinician-rated and self-rated ADHD symptoms. Treatment effect of primary outcomes was maintained at follow-up, which suggests robust and lasting findings. In contrast to the primary outcomes, the secondary outcomes showed significant improvement over time. Conclusions. The study provides evidence for the effectiveness of R&R2ADHD and demonstrates that there are differential effects over time for ADHD symptoms versus co-morbid problems, the latter taking longer to show positive effects. Support for the study was received from research grants awarded by RANNIS - the Icelandic Centre for Research (no. 080443022), the Landspitali Science Fund, and Janssen-Cilag, Iceland. No writing ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Psychological Medicine 45 13 2793 2804 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Attention-deficit/hyperactivity disorder Cognitive behavioural therapy Randomized controlled trials Reasoning and rehabilitation R & R2 Treatment Meðferð Atferlismeðferð Psychology Sálfræði |
spellingShingle |
Attention-deficit/hyperactivity disorder Cognitive behavioural therapy Randomized controlled trials Reasoning and rehabilitation R & R2 Treatment Meðferð Atferlismeðferð Psychology Sálfræði Young, Susan Khondoker, Mizanur Emilsson, B. Sigurdsson, Jon Fridrik Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, H. Gudjonsson, G. Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis |
topic_facet |
Attention-deficit/hyperactivity disorder Cognitive behavioural therapy Randomized controlled trials Reasoning and rehabilitation R & R2 Treatment Meðferð Atferlismeðferð Psychology Sálfræði |
description |
Background. Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by high rates of co-morbid psychopathology. Randomized controlled trials of multimodal interventions, combining pharmacological and psychological treatments, have shown a robust treatment effect for ADHD symptoms but outcomes for co-morbid symptoms have been mixed. This may be accounted for by the type of intervention selected and/or by methodological problems including lack of follow-up and low power. The current study addressed these limitations in a parallel-group randomized controlled trial conducted in Iceland. Method. A total of 95 adult ADHD patients who were already being treated with medication (MED) were randomly assigned to receive treatment as usual (TAU/MED) or 15 sessions of cognitive–behavioural therapy (CBT/MED) using the R&R2ADHD intervention which employs both group and individual modalities. Primary measures of ADHD symptoms and severity of illness, and secondary measures of anxiety, depression and quality of life were given at baseline, end of treatment and 3-month follow-up. Primary outcomes were rated by clinicians blind to treatment condition assignment. Results. CBT/MED showed overall (combined outcome at end of treatment and 3-month follow-up) significantly greater reduction in primary outcomes for clinician-rated and self-rated ADHD symptoms. Treatment effect of primary outcomes was maintained at follow-up, which suggests robust and lasting findings. In contrast to the primary outcomes, the secondary outcomes showed significant improvement over time. Conclusions. The study provides evidence for the effectiveness of R&R2ADHD and demonstrates that there are differential effects over time for ADHD symptoms versus co-morbid problems, the latter taking longer to show positive effects. Support for the study was received from research grants awarded by RANNIS - the Icelandic Centre for Research (no. 080443022), the Landspitali Science Fund, and Janssen-Cilag, Iceland. No writing ... |
author2 |
Viðskiptadeild (HR) School of Business (RU) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskólinn í Reykjavík (HR) Reykjavík University (RU) Háskóli Íslands (HÍ) University of Iceland (UI) |
format |
Article in Journal/Newspaper |
author |
Young, Susan Khondoker, Mizanur Emilsson, B. Sigurdsson, Jon Fridrik Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, H. Gudjonsson, G. |
author_facet |
Young, Susan Khondoker, Mizanur Emilsson, B. Sigurdsson, Jon Fridrik Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, H. Gudjonsson, G. |
author_sort |
Young, Susan |
title |
Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis |
title_short |
Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis |
title_full |
Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis |
title_fullStr |
Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis |
title_full_unstemmed |
Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis |
title_sort |
cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis |
publisher |
Cambridge University Press (CUP) |
publishDate |
2015 |
url |
https://hdl.handle.net/20.500.11815/921 https://doi.org/10.1017/S0033291715000756 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Psychological Medicine;45(13) https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0033291715000756 Young, S., Khondoker, M., Emilsson, B., Sigurdsson, J. F., Philipp-Wiegmann, F., Baldursson, G., … Gudjonsson, G. (2015). Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. Psychological Medicine, 45(13), 2793–2804. https://doi.org/10.1017/S0033291715000756 0033-2917 1469-8978( eISSN) https://hdl.handle.net/20.500.11815/921 Psychological Medicine doi:10.1017/S0033291715000756 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/921 https://doi.org/10.1017/S0033291715000756 |
container_title |
Psychological Medicine |
container_volume |
45 |
container_issue |
13 |
container_start_page |
2793 |
op_container_end_page |
2804 |
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1766039741556326400 |