Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries
Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurr...
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/698 2023-05-15T16:52:11+02:00 Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjaerheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland 2017-11-13 191-198 https://hdl.handle.net/20.500.11815/698 https://doi.org/10.1136/oemed-2017-104603 en eng BMJ Occupational and Environmental Medicine;75(3) https://syndication.highwire.org/content/doi/10.1136/oemed-2017-104603 Farioli, A., Straif, K., Brandi, G., Curti, S., Kjaerheim, K., Martinsen, J. I., . . . Pukkala, E. (2018). Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries. Occupational and Environmental Medicine, 75(3), 191-198. doi:10.1136/oemed-2017-104603 1351-0711 1470-7926 (eISSN) https://hdl.handle.net/20.500.11815/698 Occupational and Environmental Medicine doi:10.1136/oemed-2017-104603 info:eu-repo/semantics/openAccess Tilviksrannsóknir Krabbamein Gallrás Asbest Vinnuaðstaða info:eu-repo/semantics/article 2017 ftopinvisindi https://doi.org/20.500.11815/698 https://doi.org/10.1136/oemed-2017-104603 2022-11-18T06:51:36Z Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ml × years) was assessed by applying the NOCCA job-exposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work. Results We observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC. Conclusions Our study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed. Nordic Cancer Union funded the NOCCA project. The work by AF, GBr, SC, GBi, FSV and SM was partially supported by internal funds of the Department of Medical and Surgical Sciences and the Department of Experimental, Diagnostic, and Specialty Medicine of the University of Bologna. Peer Reviewed Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Norway Occupational and Environmental Medicine 75 3 191 198 |
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Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Tilviksrannsóknir Krabbamein Gallrás Asbest Vinnuaðstaða |
spellingShingle |
Tilviksrannsóknir Krabbamein Gallrás Asbest Vinnuaðstaða Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjaerheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries |
topic_facet |
Tilviksrannsóknir Krabbamein Gallrás Asbest Vinnuaðstaða |
description |
Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ml × years) was assessed by applying the NOCCA job-exposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work. Results We observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC. Conclusions Our study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed. Nordic Cancer Union funded the NOCCA project. The work by AF, GBr, SC, GBi, FSV and SM was partially supported by internal funds of the Department of Medical and Surgical Sciences and the Department of Experimental, Diagnostic, and Specialty Medicine of the University of Bologna. Peer Reviewed |
author2 |
Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland |
format |
Article in Journal/Newspaper |
author |
Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjaerheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero |
author_facet |
Farioli, Andrea Straif, Kurt Brandi, Giovanni Curti, Stefania Kjaerheim, Kristina Martinsen, Jan Ivar Sparen, Pär Tryggvadottir, Laufey Weiderpass, Elisabete Biasco, Guido Violante, Francesco Saverio Mattioli, Stefano Pukkala, Eero |
author_sort |
Farioli, Andrea |
title |
Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries |
title_short |
Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries |
title_full |
Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries |
title_fullStr |
Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries |
title_full_unstemmed |
Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries |
title_sort |
occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four nordic countries |
publisher |
BMJ |
publishDate |
2017 |
url |
https://hdl.handle.net/20.500.11815/698 https://doi.org/10.1136/oemed-2017-104603 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Occupational and Environmental Medicine;75(3) https://syndication.highwire.org/content/doi/10.1136/oemed-2017-104603 Farioli, A., Straif, K., Brandi, G., Curti, S., Kjaerheim, K., Martinsen, J. I., . . . Pukkala, E. (2018). Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries. Occupational and Environmental Medicine, 75(3), 191-198. doi:10.1136/oemed-2017-104603 1351-0711 1470-7926 (eISSN) https://hdl.handle.net/20.500.11815/698 Occupational and Environmental Medicine doi:10.1136/oemed-2017-104603 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/698 https://doi.org/10.1136/oemed-2017-104603 |
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Occupational and Environmental Medicine |
container_volume |
75 |
container_issue |
3 |
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191 |
op_container_end_page |
198 |
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1766042343389003776 |