The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study
Publisher Copyright: © Author(s) (or their employer(s)) 2024. Objectives To determine the prevalence and incidence of polypharmacy/hyperpolypharmacy and which medications are most prescribed to patients with varying burden of polypharmacy. Design Retrospective, population-based cohort study. Setting...
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/4900 2024-06-02T08:09:15+00:00 The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study Jónsdóttir, Freyja Blöndal, Anna Bryndís Guðmundsson, Aðalsteinn Bates, Ian Stevenson, Jennifer Mary Sigurðsson, Martin Ingi Other departments Faculty of Pharmaceutical Sciences Faculty of Medicine Health Sciences 2024-03-28 879990 https://hdl.handle.net/20.500.11815/4900 https://doi.org/10.1136/bmjopen-2023-078890 en eng BMJ Open; 14(3) http://www.scopus.com/inward/record.url?scp=85189261449&partnerID=8YFLogxK Jónsdóttir , F , Blöndal , A B , Guðmundsson , A , Bates , I , Stevenson , J M & Sigurðsson , M I 2024 , ' The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study ' , BMJ Open , vol. 14 , no. 3 , e078890 . https://doi.org/10.1136/bmjopen-2023-078890 2044-6055 222118307 61182256-d6ba-4146-b370-874f22572ea2 85189261449 38548367 https://hdl.handle.net/20.500.11815/4900 doi:10.1136/bmjopen-2023-078890 info:eu-repo/semantics/openAccess Lyfjafræðingar Öldrunarlæknisfræði Svæfinga- og gjörgæslulæknisfræði General Medicine /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2024 ftopinvisindi https://doi.org/20.500.11815/490010.1136/bmjopen-2023-078890 2024-05-06T02:20:07Z Publisher Copyright: © Author(s) (or their employer(s)) 2024. Objectives To determine the prevalence and incidence of polypharmacy/hyperpolypharmacy and which medications are most prescribed to patients with varying burden of polypharmacy. Design Retrospective, population-based cohort study. Setting Iceland. Participants Including patients (≥18 years) admitted to internal medicine services at Landspitali – The National University Hospital of Iceland, between 1 January 2010 with a follow-up of clinical outcomes through 17 March 2022. Main outcomes measures Participants were categorised into medication use categories of non-polypharmacy (<5), polypharmacy (5–10) and hyperpolypharmacy (>10) based on the number of medications filled in the year predischarge and postdischarge. The primary outcome was prevalence and incidence of new polypharmacy. Secondary outcomes were mortality, length of hospital stay and re-admission. Results Among 85 942 admissions (51% male), the median (IQR) age was 73 (60–83) years. The prevalence of preadmission non-polypharmacy was 15.1% (95% CI 14.9 to 15.3), polypharmacy was 22.9% (95% CI 22.6 to 23.2) and hyperpolypharmacy was 62.5% (95% CI 62.2 to 62.9). The incidence of new postdischarge polypharmacy was 33.4% (95% CI 32.9 to 33.9), and for hyperpolypharmacy was 28.9% (95% CI 28.3 to 29.5) for patients with preadmission polypharmacy. Patients with a higher level of medication use were more likely to use multidose drug dispensing and have a diagnosis of adverse drug reaction. Other comorbidities, including responsible subspeciality and estimates of comorbidity and frailty burden, were identical between groups of varying polypharmacy. There was no difference in length of stay, re-admission rate and mortality. Conclusions Preadmission polypharmacy/hyperpolypharmacy and postdischarge new polypharmacy/hyperpolypharmacy is common amongst patients admitted to internal medicine. A higher level of medication use category was not found to be associated with demographic, comorbidity and ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) BMJ Open 14 3 e078890 |
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Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Lyfjafræðingar Öldrunarlæknisfræði Svæfinga- og gjörgæslulæknisfræði General Medicine |
spellingShingle |
Lyfjafræðingar Öldrunarlæknisfræði Svæfinga- og gjörgæslulæknisfræði General Medicine Jónsdóttir, Freyja Blöndal, Anna Bryndís Guðmundsson, Aðalsteinn Bates, Ian Stevenson, Jennifer Mary Sigurðsson, Martin Ingi The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study |
topic_facet |
Lyfjafræðingar Öldrunarlæknisfræði Svæfinga- og gjörgæslulæknisfræði General Medicine |
description |
Publisher Copyright: © Author(s) (or their employer(s)) 2024. Objectives To determine the prevalence and incidence of polypharmacy/hyperpolypharmacy and which medications are most prescribed to patients with varying burden of polypharmacy. Design Retrospective, population-based cohort study. Setting Iceland. Participants Including patients (≥18 years) admitted to internal medicine services at Landspitali – The National University Hospital of Iceland, between 1 January 2010 with a follow-up of clinical outcomes through 17 March 2022. Main outcomes measures Participants were categorised into medication use categories of non-polypharmacy (<5), polypharmacy (5–10) and hyperpolypharmacy (>10) based on the number of medications filled in the year predischarge and postdischarge. The primary outcome was prevalence and incidence of new polypharmacy. Secondary outcomes were mortality, length of hospital stay and re-admission. Results Among 85 942 admissions (51% male), the median (IQR) age was 73 (60–83) years. The prevalence of preadmission non-polypharmacy was 15.1% (95% CI 14.9 to 15.3), polypharmacy was 22.9% (95% CI 22.6 to 23.2) and hyperpolypharmacy was 62.5% (95% CI 62.2 to 62.9). The incidence of new postdischarge polypharmacy was 33.4% (95% CI 32.9 to 33.9), and for hyperpolypharmacy was 28.9% (95% CI 28.3 to 29.5) for patients with preadmission polypharmacy. Patients with a higher level of medication use were more likely to use multidose drug dispensing and have a diagnosis of adverse drug reaction. Other comorbidities, including responsible subspeciality and estimates of comorbidity and frailty burden, were identical between groups of varying polypharmacy. There was no difference in length of stay, re-admission rate and mortality. Conclusions Preadmission polypharmacy/hyperpolypharmacy and postdischarge new polypharmacy/hyperpolypharmacy is common amongst patients admitted to internal medicine. A higher level of medication use category was not found to be associated with demographic, comorbidity and ... |
author2 |
Other departments Faculty of Pharmaceutical Sciences Faculty of Medicine Health Sciences |
format |
Article in Journal/Newspaper |
author |
Jónsdóttir, Freyja Blöndal, Anna Bryndís Guðmundsson, Aðalsteinn Bates, Ian Stevenson, Jennifer Mary Sigurðsson, Martin Ingi |
author_facet |
Jónsdóttir, Freyja Blöndal, Anna Bryndís Guðmundsson, Aðalsteinn Bates, Ian Stevenson, Jennifer Mary Sigurðsson, Martin Ingi |
author_sort |
Jónsdóttir, Freyja |
title |
The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study |
title_short |
The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study |
title_full |
The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study |
title_fullStr |
The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study |
title_full_unstemmed |
The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study |
title_sort |
association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study |
publishDate |
2024 |
url |
https://hdl.handle.net/20.500.11815/4900 https://doi.org/10.1136/bmjopen-2023-078890 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
BMJ Open; 14(3) http://www.scopus.com/inward/record.url?scp=85189261449&partnerID=8YFLogxK Jónsdóttir , F , Blöndal , A B , Guðmundsson , A , Bates , I , Stevenson , J M & Sigurðsson , M I 2024 , ' The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study ' , BMJ Open , vol. 14 , no. 3 , e078890 . https://doi.org/10.1136/bmjopen-2023-078890 2044-6055 222118307 61182256-d6ba-4146-b370-874f22572ea2 85189261449 38548367 https://hdl.handle.net/20.500.11815/4900 doi:10.1136/bmjopen-2023-078890 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/490010.1136/bmjopen-2023-078890 |
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BMJ Open |
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14 |
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e078890 |
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