Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia
Funding Information: Adrian Bogdan Tigu and Catalin Constantinescu contributed equally to the current manuscript. Catalin Constantinescu is funded by an internal grant of the Iuliu Hatieganu University – School of Doctoral Studies. David Kegyes is funded by an internal grant of the Iuliu Hatieganu U...
Published in: | Journal of Cellular and Molecular Medicine |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2023
|
Subjects: | |
Online Access: | https://hdl.handle.net/20.500.11815/4463 https://doi.org/10.1111/jcmm.17810 |
id |
ftopinvisindi:oai:opinvisindi.is:20.500.11815/4463 |
---|---|
record_format |
openpolar |
spelling |
ftopinvisindi:oai:opinvisindi.is:20.500.11815/4463 2023-11-12T04:19:34+01:00 Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia Tigu, Adrian Bogdan Constantinescu, Catalin Sorin Teodorescu, Patric Kegyes, David Munteanu, Raluca Feder, Richard Peters, Mareike Pralea, Ioana Iuga, Cristina Cenariu, Diana Marcu, Andra Tanase, Alina Colita, Anca Drula, Rares Bergþórsson, Jón Þór Greiff, Victor Dima, Delia Selicean, Cristina Rus, Ioana Zdrenghea, Mihnea Gulei, Diana Ghiaur, Gabriel Tomuleasa, Ciprian Other departments Faculty of Medicine 2023-10 12 2539137 2864-2875 https://hdl.handle.net/20.500.11815/4463 https://doi.org/10.1111/jcmm.17810 en eng Journal of Cellular and Molecular Medicine; 27(19) http://www.scopus.com/inward/record.url?scp=85169808579&partnerID=8YFLogxK Tigu , A B , Constantinescu , C S , Teodorescu , P , Kegyes , D , Munteanu , R , Feder , R , Peters , M , Pralea , I , Iuga , C , Cenariu , D , Marcu , A , Tanase , A , Colita , A , Drula , R , Bergþórsson , J Þ , Greiff , V , Dima , D , Selicean , C , Rus , I , Zdrenghea , M , Gulei , D , Ghiaur , G & Tomuleasa , C 2023 , ' Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia ' , Journal of Cellular and Molecular Medicine , vol. 27 , no. 19 , pp. 2864-2875 . https://doi.org/10.1111/jcmm.17810 1582-1838 182427000 963b3652-2281-4c51-b0d2-557fd82e4ab3 37667538 85169808579 unpaywall: 10.1111/jcmm.17810 https://hdl.handle.net/20.500.11815/4463 doi:10.1111/jcmm.17810 info:eu-repo/semantics/openAccess Náttúrufræðingar B cell CAR T cells CRS megakaryoblastic leukaemia Molecular Medicine Cell Biology /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2023 ftopinvisindi https://doi.org/20.500.11815/446310.1111/jcmm.17810 2023-11-01T23:55:29Z Funding Information: Adrian Bogdan Tigu and Catalin Constantinescu contributed equally to the current manuscript. Catalin Constantinescu is funded by an internal grant of the Iuliu Hatieganu University – School of Doctoral Studies. David Kegyes is funded by an internal grant of the Iuliu Hatieganu University – School of Medicine. Mareike Peters is funded by a national grant of the Romanian Society for Bone Marrow Transplantation. Ciprian Tomuleasa is also supported by a grant awarded by the Romanian National Ministry of Research, Innovation and Digitalization: PN‐III‐P4‐ID‐PCE‐2020‐1118 within PNCDI IV, Projects for Exploratory Medicine; Projects for Exploratory Medicine—PCE 225/2021; as well as a national grant awarded to Young Research Teams (PN‐III‐PI‐1.1‐TE‐2019‐0271 –‘Supporting a team of young researchers to create an independent research program based on the use of Sleeping Beauty protocol f or the development of CAR T Cells – SEATTLE’). Diana Gulei, Diana Cenariu, Adrian Bogdan Tigu, Jon Thor Bergthorsson and Victor Greiff are supported by an international collaborative grant of the European Economic Space between Romania and Iceland 2021–2023: ‘Cooperation strategy for knowledge transfer, internationalization and curricula innovation in the field of research education at the 3rd level of study –AURORA.’ Publisher Copyright: © 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. Acute megakaryoblastic leukaemia (AMkL) is a rare subtype of acute myeloid leukaemia (AML) representing 5% of all reported cases, and frequently diagnosed in children with Down syndrome. Patients diagnosed with AMkL have low overall survival and have poor outcome to treatment, thus novel therapies such as CAR T cell therapy could represent an alternative in treating AMkL. We investigated the effect of a new CAR T cell which targets CD41, a specific surface antigen for M7-AMkL, against an in vitro model for AMkL, DAMI Luc2 cell ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Journal of Cellular and Molecular Medicine 27 19 2864 2875 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Náttúrufræðingar B cell CAR T cells CRS megakaryoblastic leukaemia Molecular Medicine Cell Biology |
spellingShingle |
Náttúrufræðingar B cell CAR T cells CRS megakaryoblastic leukaemia Molecular Medicine Cell Biology Tigu, Adrian Bogdan Constantinescu, Catalin Sorin Teodorescu, Patric Kegyes, David Munteanu, Raluca Feder, Richard Peters, Mareike Pralea, Ioana Iuga, Cristina Cenariu, Diana Marcu, Andra Tanase, Alina Colita, Anca Drula, Rares Bergþórsson, Jón Þór Greiff, Victor Dima, Delia Selicean, Cristina Rus, Ioana Zdrenghea, Mihnea Gulei, Diana Ghiaur, Gabriel Tomuleasa, Ciprian Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia |
topic_facet |
Náttúrufræðingar B cell CAR T cells CRS megakaryoblastic leukaemia Molecular Medicine Cell Biology |
description |
Funding Information: Adrian Bogdan Tigu and Catalin Constantinescu contributed equally to the current manuscript. Catalin Constantinescu is funded by an internal grant of the Iuliu Hatieganu University – School of Doctoral Studies. David Kegyes is funded by an internal grant of the Iuliu Hatieganu University – School of Medicine. Mareike Peters is funded by a national grant of the Romanian Society for Bone Marrow Transplantation. Ciprian Tomuleasa is also supported by a grant awarded by the Romanian National Ministry of Research, Innovation and Digitalization: PN‐III‐P4‐ID‐PCE‐2020‐1118 within PNCDI IV, Projects for Exploratory Medicine; Projects for Exploratory Medicine—PCE 225/2021; as well as a national grant awarded to Young Research Teams (PN‐III‐PI‐1.1‐TE‐2019‐0271 –‘Supporting a team of young researchers to create an independent research program based on the use of Sleeping Beauty protocol f or the development of CAR T Cells – SEATTLE’). Diana Gulei, Diana Cenariu, Adrian Bogdan Tigu, Jon Thor Bergthorsson and Victor Greiff are supported by an international collaborative grant of the European Economic Space between Romania and Iceland 2021–2023: ‘Cooperation strategy for knowledge transfer, internationalization and curricula innovation in the field of research education at the 3rd level of study –AURORA.’ Publisher Copyright: © 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. Acute megakaryoblastic leukaemia (AMkL) is a rare subtype of acute myeloid leukaemia (AML) representing 5% of all reported cases, and frequently diagnosed in children with Down syndrome. Patients diagnosed with AMkL have low overall survival and have poor outcome to treatment, thus novel therapies such as CAR T cell therapy could represent an alternative in treating AMkL. We investigated the effect of a new CAR T cell which targets CD41, a specific surface antigen for M7-AMkL, against an in vitro model for AMkL, DAMI Luc2 cell ... |
author2 |
Other departments Faculty of Medicine |
format |
Article in Journal/Newspaper |
author |
Tigu, Adrian Bogdan Constantinescu, Catalin Sorin Teodorescu, Patric Kegyes, David Munteanu, Raluca Feder, Richard Peters, Mareike Pralea, Ioana Iuga, Cristina Cenariu, Diana Marcu, Andra Tanase, Alina Colita, Anca Drula, Rares Bergþórsson, Jón Þór Greiff, Victor Dima, Delia Selicean, Cristina Rus, Ioana Zdrenghea, Mihnea Gulei, Diana Ghiaur, Gabriel Tomuleasa, Ciprian |
author_facet |
Tigu, Adrian Bogdan Constantinescu, Catalin Sorin Teodorescu, Patric Kegyes, David Munteanu, Raluca Feder, Richard Peters, Mareike Pralea, Ioana Iuga, Cristina Cenariu, Diana Marcu, Andra Tanase, Alina Colita, Anca Drula, Rares Bergþórsson, Jón Þór Greiff, Victor Dima, Delia Selicean, Cristina Rus, Ioana Zdrenghea, Mihnea Gulei, Diana Ghiaur, Gabriel Tomuleasa, Ciprian |
author_sort |
Tigu, Adrian Bogdan |
title |
Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia |
title_short |
Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia |
title_full |
Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia |
title_fullStr |
Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia |
title_full_unstemmed |
Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia |
title_sort |
design and preclinical testing of an anti-cd41 car t cell for the treatment of acute megakaryoblastic leukaemia |
publishDate |
2023 |
url |
https://hdl.handle.net/20.500.11815/4463 https://doi.org/10.1111/jcmm.17810 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Journal of Cellular and Molecular Medicine; 27(19) http://www.scopus.com/inward/record.url?scp=85169808579&partnerID=8YFLogxK Tigu , A B , Constantinescu , C S , Teodorescu , P , Kegyes , D , Munteanu , R , Feder , R , Peters , M , Pralea , I , Iuga , C , Cenariu , D , Marcu , A , Tanase , A , Colita , A , Drula , R , Bergþórsson , J Þ , Greiff , V , Dima , D , Selicean , C , Rus , I , Zdrenghea , M , Gulei , D , Ghiaur , G & Tomuleasa , C 2023 , ' Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia ' , Journal of Cellular and Molecular Medicine , vol. 27 , no. 19 , pp. 2864-2875 . https://doi.org/10.1111/jcmm.17810 1582-1838 182427000 963b3652-2281-4c51-b0d2-557fd82e4ab3 37667538 85169808579 unpaywall: 10.1111/jcmm.17810 https://hdl.handle.net/20.500.11815/4463 doi:10.1111/jcmm.17810 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/446310.1111/jcmm.17810 |
container_title |
Journal of Cellular and Molecular Medicine |
container_volume |
27 |
container_issue |
19 |
container_start_page |
2864 |
op_container_end_page |
2875 |
_version_ |
1782335966109761536 |