Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids
Funding Information: The Co-OPT ACS study is funded through a Wellcome Trust Clinical Career Development Fellowship grant (Funding Reference number 209560/Z/17) awarded to Sarah J Stock. The funders had no role in study design, data collection, data analysis, decision to publish, or preparation of t...
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2023
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Online Access: | https://hdl.handle.net/20.500.11815/4443 https://doi.org/10.1371/journal.pone.0282477 |
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Infant Newborn Pregnancy Child Humans Female Preschool Birth Cohort Premature Birth/epidemiology Child Health Family Adrenal Cortex Hormones/therapeutic use Multidisciplinary |
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Infant Newborn Pregnancy Child Humans Female Preschool Birth Cohort Premature Birth/epidemiology Child Health Family Adrenal Cortex Hormones/therapeutic use Multidisciplinary Frier, Emily M. Lin, Chun Reynolds, Rebecca M. Allegaert, Karel Been, Jasper V. Fraser, Abigail Gissler, Mika Einarsdóttir, Kristjana Florian, Lani Jacobsson, Bo Vogel, Joshua P. Zoega, Helga Bhattacharya, Sohinee Krispin, Eyal Pedersen, Lars Henning Roberts, Devender Kuhle, Stefan Fahey, John Mol, Ben W. Burgner, David Schuit, Ewoud Sheikh, Aziz Wood, Rachael Gyamfi-Bannerman, Cynthia Miller, Jessica E. Duhig, Kate Lahti-Pulkkinen, Marius Hadar, Eran Wright, John Murray, Sarah R. Stock, Sarah J. Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids |
topic_facet |
Infant Newborn Pregnancy Child Humans Female Preschool Birth Cohort Premature Birth/epidemiology Child Health Family Adrenal Cortex Hormones/therapeutic use Multidisciplinary |
description |
Funding Information: The Co-OPT ACS study is funded through a Wellcome Trust Clinical Career Development Fellowship grant (Funding Reference number 209560/Z/17) awarded to Sarah J Stock. The funders had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript. The Sponsor of the study is the University of Edinburgh (www.ed.ac. uk), Sponsor reference AC19119. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: Copyright: © 2023 Frier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Antenatal corticosteroids (ACS) are widely prescribed to improve outcomes following preterm birth. Significant knowledge gaps surround their safety, long-term effects, optimal timing and dosage. Almost half of women given ACS give birth outside the “therapeutic window” and have not delivered over 7 days later. Overtreatment with ACS is a concern, as evidence accumulates of risks of unnecessary ACS exposure. Methods The Consortium for the Study of Pregnancy Treatments (Co-OPT) was established to address research questions surrounding safety of medications in pregnancy. We created an international birth cohort containing information on ACS exposure and pregnancy and neonatal outcomes by combining data from four national/provincial birth registers and one hospital database, and follow-up through linked population-level data from death registers and electronic health records. Results and discussion The Co-OPT ACS cohort contains 2.28 million pregnancies and babies, born in Finland, Iceland, Israel, Canada and Scotland, between 1990 and 2019. Births from 22 to 45 weeks’ gestation were included; 92.9% were at term (≥ 37 completed weeks). 3.6% of babies were ... |
author2 |
Faculty of Medicine |
format |
Article in Journal/Newspaper |
author |
Frier, Emily M. Lin, Chun Reynolds, Rebecca M. Allegaert, Karel Been, Jasper V. Fraser, Abigail Gissler, Mika Einarsdóttir, Kristjana Florian, Lani Jacobsson, Bo Vogel, Joshua P. Zoega, Helga Bhattacharya, Sohinee Krispin, Eyal Pedersen, Lars Henning Roberts, Devender Kuhle, Stefan Fahey, John Mol, Ben W. Burgner, David Schuit, Ewoud Sheikh, Aziz Wood, Rachael Gyamfi-Bannerman, Cynthia Miller, Jessica E. Duhig, Kate Lahti-Pulkkinen, Marius Hadar, Eran Wright, John Murray, Sarah R. Stock, Sarah J. |
author_facet |
Frier, Emily M. Lin, Chun Reynolds, Rebecca M. Allegaert, Karel Been, Jasper V. Fraser, Abigail Gissler, Mika Einarsdóttir, Kristjana Florian, Lani Jacobsson, Bo Vogel, Joshua P. Zoega, Helga Bhattacharya, Sohinee Krispin, Eyal Pedersen, Lars Henning Roberts, Devender Kuhle, Stefan Fahey, John Mol, Ben W. Burgner, David Schuit, Ewoud Sheikh, Aziz Wood, Rachael Gyamfi-Bannerman, Cynthia Miller, Jessica E. Duhig, Kate Lahti-Pulkkinen, Marius Hadar, Eran Wright, John Murray, Sarah R. Stock, Sarah J. |
author_sort |
Frier, Emily M. |
title |
Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids |
title_short |
Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids |
title_full |
Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids |
title_fullStr |
Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids |
title_full_unstemmed |
Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids |
title_sort |
consortium for the study of pregnancy treatments (co-opt) : an international birth cohort to study the effects of antenatal corticosteroids |
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2023 |
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https://hdl.handle.net/20.500.11815/4443 https://doi.org/10.1371/journal.pone.0282477 |
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Canada |
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Iceland |
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Iceland |
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PLoS ONE; 18(3) http://www.scopus.com/inward/record.url?scp=85149279482&partnerID=8YFLogxK Frier , E M , Lin , C , Reynolds , R M , Allegaert , K , Been , J V , Fraser , A , Gissler , M , Einarsdóttir , K , Florian , L , Jacobsson , B , Vogel , J P , Zoega , H , Bhattacharya , S , Krispin , E , Pedersen , L H , Roberts , D , Kuhle , S , Fahey , J , Mol , B W , Burgner , D , Schuit , E , Sheikh , A , Wood , R , Gyamfi-Bannerman , C , Miller , J E , Duhig , K , Lahti-Pulkkinen , M , Hadar , E , Wright , J , Murray , S R & Stock , S J 2023 , ' Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids ' , PLoS ONE , vol. 18 , no. 3 , e0282477 , pp. e0282477 . https://doi.org/10.1371/journal.pone.0282477 1932-6203 155765790 ad605c4a-27ed-4dbd-8296-470e572661b3 85149279482 36862657 unpaywall: 10.1371/journal.pone.0282477 https://hdl.handle.net/20.500.11815/4443 doi:10.1371/journal.pone.0282477 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/4443 2023-11-12T04:19:35+01:00 Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids Frier, Emily M. Lin, Chun Reynolds, Rebecca M. Allegaert, Karel Been, Jasper V. Fraser, Abigail Gissler, Mika Einarsdóttir, Kristjana Florian, Lani Jacobsson, Bo Vogel, Joshua P. Zoega, Helga Bhattacharya, Sohinee Krispin, Eyal Pedersen, Lars Henning Roberts, Devender Kuhle, Stefan Fahey, John Mol, Ben W. Burgner, David Schuit, Ewoud Sheikh, Aziz Wood, Rachael Gyamfi-Bannerman, Cynthia Miller, Jessica E. Duhig, Kate Lahti-Pulkkinen, Marius Hadar, Eran Wright, John Murray, Sarah R. Stock, Sarah J. Faculty of Medicine 2023-03-02 2986427 e0282477 https://hdl.handle.net/20.500.11815/4443 https://doi.org/10.1371/journal.pone.0282477 en eng PLoS ONE; 18(3) http://www.scopus.com/inward/record.url?scp=85149279482&partnerID=8YFLogxK Frier , E M , Lin , C , Reynolds , R M , Allegaert , K , Been , J V , Fraser , A , Gissler , M , Einarsdóttir , K , Florian , L , Jacobsson , B , Vogel , J P , Zoega , H , Bhattacharya , S , Krispin , E , Pedersen , L H , Roberts , D , Kuhle , S , Fahey , J , Mol , B W , Burgner , D , Schuit , E , Sheikh , A , Wood , R , Gyamfi-Bannerman , C , Miller , J E , Duhig , K , Lahti-Pulkkinen , M , Hadar , E , Wright , J , Murray , S R & Stock , S J 2023 , ' Consortium for the Study of Pregnancy Treatments (Co-OPT) : An international birth cohort to study the effects of antenatal corticosteroids ' , PLoS ONE , vol. 18 , no. 3 , e0282477 , pp. e0282477 . https://doi.org/10.1371/journal.pone.0282477 1932-6203 155765790 ad605c4a-27ed-4dbd-8296-470e572661b3 85149279482 36862657 unpaywall: 10.1371/journal.pone.0282477 https://hdl.handle.net/20.500.11815/4443 doi:10.1371/journal.pone.0282477 info:eu-repo/semantics/openAccess Infant Newborn Pregnancy Child Humans Female Preschool Birth Cohort Premature Birth/epidemiology Child Health Family Adrenal Cortex Hormones/therapeutic use Multidisciplinary /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2023 ftopinvisindi https://doi.org/20.500.11815/444310.1371/journal.pone.0282477 2023-11-01T23:55:29Z Funding Information: The Co-OPT ACS study is funded through a Wellcome Trust Clinical Career Development Fellowship grant (Funding Reference number 209560/Z/17) awarded to Sarah J Stock. The funders had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript. The Sponsor of the study is the University of Edinburgh (www.ed.ac. uk), Sponsor reference AC19119. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: Copyright: © 2023 Frier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Antenatal corticosteroids (ACS) are widely prescribed to improve outcomes following preterm birth. Significant knowledge gaps surround their safety, long-term effects, optimal timing and dosage. Almost half of women given ACS give birth outside the “therapeutic window” and have not delivered over 7 days later. Overtreatment with ACS is a concern, as evidence accumulates of risks of unnecessary ACS exposure. Methods The Consortium for the Study of Pregnancy Treatments (Co-OPT) was established to address research questions surrounding safety of medications in pregnancy. We created an international birth cohort containing information on ACS exposure and pregnancy and neonatal outcomes by combining data from four national/provincial birth registers and one hospital database, and follow-up through linked population-level data from death registers and electronic health records. Results and discussion The Co-OPT ACS cohort contains 2.28 million pregnancies and babies, born in Finland, Iceland, Israel, Canada and Scotland, between 1990 and 2019. Births from 22 to 45 weeks’ gestation were included; 92.9% were at term (≥ 37 completed weeks). 3.6% of babies were ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Canada PLOS ONE 18 3 e0282477 |