Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy
Funding Information: G.K. acknowledges lab support provided by grants from the Icelandic Research Fund (217946-051), the Icelandic Cancer Society Research Fund and the University of Iceland Research Fund. A.G.L. acknowledges financial support provided by a Postdoctoral Fellowship grant from the Icel...
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/4373 2023-11-12T04:19:24+01:00 Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy García-Llorca, Andrea Kararigas, Georgios Faculty of Nursing and Midwifery Faculty of Medicine 2023-02-10 759079 https://hdl.handle.net/20.500.11815/4373 https://doi.org/10.3390/microorganisms11020447 en eng Microorganisms; 11(2) http://www.scopus.com/inward/record.url?scp=85149039514&partnerID=8YFLogxK García-Llorca , A & Kararigas , G 2023 , ' Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy ' , Microorganisms , vol. 11 , no. 2 , 447 . https://doi.org/10.3390/microorganisms11020447 2076-2607 155775748 88abcfab-ea93-4747-9e82-235d8e8f2d5e 85149039514 unpaywall: 10.3390/microorganisms11020447 36838411 https://hdl.handle.net/20.500.11815/4373 doi:10.3390/microorganisms11020447 info:eu-repo/semantics/openAccess biological sex biomarkers cardiovascular disease diabetic retinopathy gut microbiota metabolic syndrome Microbiology Microbiology (medical) Virology /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2023 ftopinvisindi https://doi.org/20.500.11815/437310.3390/microorganisms11020447 2023-11-01T23:55:29Z Funding Information: G.K. acknowledges lab support provided by grants from the Icelandic Research Fund (217946-051), the Icelandic Cancer Society Research Fund and the University of Iceland Research Fund. A.G.L. acknowledges financial support provided by a Postdoctoral Fellowship grant from the Icelandic Research Fund (217796-052). Publisher Copyright: © 2023 by the authors. The metabolic syndrome (MetS) is a complex disease of metabolic abnormalities, including obesity, insulin resistance, hypertension and dyslipidaemia, and it is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is the leading cause of vision loss among working-aged adults around the world and is the most frequent complication in type 2 diabetic (T2D) patients. The gut microbiota are a complex ecosystem made up of more than 100 trillion of microbial cells and their composition and diversity have been identified as potential risk factors for the development of several metabolic disorders, including MetS, T2D, DR and CVD. Biomarkers are used to monitor or analyse biological processes, therapeutic responses, as well as for the early detection of pathogenic disorders. Here, we discuss molecular mechanisms underlying MetS, the effects of biological sex in MetS-related DR and gut microbiota, as well as the latest advances in biomarker research in the field. We conclude that sex may play an important role in gut microbiota influencing MetS-related DR. Peer reviewed Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Microorganisms 11 2 447 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
biological sex biomarkers cardiovascular disease diabetic retinopathy gut microbiota metabolic syndrome Microbiology Microbiology (medical) Virology |
spellingShingle |
biological sex biomarkers cardiovascular disease diabetic retinopathy gut microbiota metabolic syndrome Microbiology Microbiology (medical) Virology García-Llorca, Andrea Kararigas, Georgios Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy |
topic_facet |
biological sex biomarkers cardiovascular disease diabetic retinopathy gut microbiota metabolic syndrome Microbiology Microbiology (medical) Virology |
description |
Funding Information: G.K. acknowledges lab support provided by grants from the Icelandic Research Fund (217946-051), the Icelandic Cancer Society Research Fund and the University of Iceland Research Fund. A.G.L. acknowledges financial support provided by a Postdoctoral Fellowship grant from the Icelandic Research Fund (217796-052). Publisher Copyright: © 2023 by the authors. The metabolic syndrome (MetS) is a complex disease of metabolic abnormalities, including obesity, insulin resistance, hypertension and dyslipidaemia, and it is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is the leading cause of vision loss among working-aged adults around the world and is the most frequent complication in type 2 diabetic (T2D) patients. The gut microbiota are a complex ecosystem made up of more than 100 trillion of microbial cells and their composition and diversity have been identified as potential risk factors for the development of several metabolic disorders, including MetS, T2D, DR and CVD. Biomarkers are used to monitor or analyse biological processes, therapeutic responses, as well as for the early detection of pathogenic disorders. Here, we discuss molecular mechanisms underlying MetS, the effects of biological sex in MetS-related DR and gut microbiota, as well as the latest advances in biomarker research in the field. We conclude that sex may play an important role in gut microbiota influencing MetS-related DR. Peer reviewed |
author2 |
Faculty of Nursing and Midwifery Faculty of Medicine |
format |
Article in Journal/Newspaper |
author |
García-Llorca, Andrea Kararigas, Georgios |
author_facet |
García-Llorca, Andrea Kararigas, Georgios |
author_sort |
García-Llorca, Andrea |
title |
Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy |
title_short |
Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy |
title_full |
Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy |
title_fullStr |
Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy |
title_full_unstemmed |
Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy |
title_sort |
sex-related effects of gut microbiota in metabolic syndrome-related diabetic retinopathy |
publishDate |
2023 |
url |
https://hdl.handle.net/20.500.11815/4373 https://doi.org/10.3390/microorganisms11020447 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Microorganisms; 11(2) http://www.scopus.com/inward/record.url?scp=85149039514&partnerID=8YFLogxK García-Llorca , A & Kararigas , G 2023 , ' Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy ' , Microorganisms , vol. 11 , no. 2 , 447 . https://doi.org/10.3390/microorganisms11020447 2076-2607 155775748 88abcfab-ea93-4747-9e82-235d8e8f2d5e 85149039514 unpaywall: 10.3390/microorganisms11020447 36838411 https://hdl.handle.net/20.500.11815/4373 doi:10.3390/microorganisms11020447 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/437310.3390/microorganisms11020447 |
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Microorganisms |
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11 |
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447 |
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