The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland
Funding Information: The study is sponsored by deCODE genetics, Inc./Amgen Inc. The authors independently collected the data, interpreted the results, and had the final decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Amgen. Publisher...
Published in: | Arthritis & Rheumatology |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2021
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Online Access: | https://hdl.handle.net/20.500.11815/4321 https://doi.org/10.1002/art.41793 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/4321 |
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Open Polar |
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Opin vísindi (Iceland) |
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English |
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Liðskiptaaðgerðir Prótín Slitgigt Adult Aged Arthroplasty Replacement Biomarkers/blood Calcium-Binding Proteins/blood Case-Control Studies Disease Progression Female Humans Iceland Male Middle Aged Osteoarthritis/blood Prospective Studies Proteomics |
spellingShingle |
Liðskiptaaðgerðir Prótín Slitgigt Adult Aged Arthroplasty Replacement Biomarkers/blood Calcium-Binding Proteins/blood Case-Control Studies Disease Progression Female Humans Iceland Male Middle Aged Osteoarthritis/blood Prospective Studies Proteomics Styrkarsdottir, Unnur Lund, S.H. Saevarsdottir, S. Magnusson, M.I. Gunnarsdottir, K. Norddahl, Gudmundur L. Frigge, Michael L. Ivarsdottir, E.V. Bjornsdottir, Gyda Holm, Hilma Thorgeirsson, Guðmundur Rafnar, T. Jonsdottir, I. Ingvarsson, T. Jonsson, H. Sulem, P. Thorsteinsdottir, U. Gudbjartsson, Daniel Fannar Stefansson, K. Thorgeirsson, Gudmundur Ingvarsson, Þorvaldur The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland |
topic_facet |
Liðskiptaaðgerðir Prótín Slitgigt Adult Aged Arthroplasty Replacement Biomarkers/blood Calcium-Binding Proteins/blood Case-Control Studies Disease Progression Female Humans Iceland Male Middle Aged Osteoarthritis/blood Prospective Studies Proteomics |
description |
Funding Information: The study is sponsored by deCODE genetics, Inc./Amgen Inc. The authors independently collected the data, interpreted the results, and had the final decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Amgen. Publisher Copyright: © 2021 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case–control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement. Results: Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95% confidence interval 1.41–1.52] for knee OA, odds ratio 1.36 [95% confidence interval 1.29–1.43] for hip OA, and odds ratio 1.33 [95% confidence interval 1.26–1.40] for hand OA) and progression to joint replacement (hazard ratio 1.40 [95% confidence interval 1.30–1.51] for knee replacement and hazard ratio 1.31 [95% confidence interval 1.19–1.45] for hip replacement). Patients with OA who were in the highest quintile of risk of joint replacement, based on known risk factors (i.e., age, sex, and body mass index) and plasma CRTAC1 level, were 16 times more likely to undergo knee replacement within 5 years of plasma sample collection than those in the lowest quintile, and 6.5 times more likely to undergo hip replacement. CRTAC1 was not associated with other types of inflammatory arthritis. A specific protein ... |
author2 |
Faculty of Physical Sciences Faculty of Medicine Internal Medicine and Emergency Services Faculty of Earth Sciences Clinical Laboratory Services, Diagnostics and Blood Bank Health Sciences School of Health Sciences Landspitali - The National University Hospital of Iceland |
format |
Article in Journal/Newspaper |
author |
Styrkarsdottir, Unnur Lund, S.H. Saevarsdottir, S. Magnusson, M.I. Gunnarsdottir, K. Norddahl, Gudmundur L. Frigge, Michael L. Ivarsdottir, E.V. Bjornsdottir, Gyda Holm, Hilma Thorgeirsson, Guðmundur Rafnar, T. Jonsdottir, I. Ingvarsson, T. Jonsson, H. Sulem, P. Thorsteinsdottir, U. Gudbjartsson, Daniel Fannar Stefansson, K. Thorgeirsson, Gudmundur Ingvarsson, Þorvaldur |
author_facet |
Styrkarsdottir, Unnur Lund, S.H. Saevarsdottir, S. Magnusson, M.I. Gunnarsdottir, K. Norddahl, Gudmundur L. Frigge, Michael L. Ivarsdottir, E.V. Bjornsdottir, Gyda Holm, Hilma Thorgeirsson, Guðmundur Rafnar, T. Jonsdottir, I. Ingvarsson, T. Jonsson, H. Sulem, P. Thorsteinsdottir, U. Gudbjartsson, Daniel Fannar Stefansson, K. Thorgeirsson, Gudmundur Ingvarsson, Þorvaldur |
author_sort |
Styrkarsdottir, Unnur |
title |
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland |
title_short |
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland |
title_full |
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland |
title_fullStr |
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland |
title_full_unstemmed |
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland |
title_sort |
crtac1 protein in plasma is associated with osteoarthritis and predicts progression to joint replacement: a large-scale proteomics scan in iceland : a large-scale proteomics scan in iceland |
publishDate |
2021 |
url |
https://hdl.handle.net/20.500.11815/4321 https://doi.org/10.1002/art.41793 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Arthritis and Rheumatology; 73(11) http://www.scopus.com/inward/record.url?eid=2-s2.0-85114618454&partnerID=MN8TOARS http://www.scopus.com/inward/record.url?scp=85114618454&partnerID=8YFLogxK Styrkarsdottir , U , Lund , S H , Saevarsdottir , S , Magnusson , M I , Gunnarsdottir , K , Norddahl , G L , Frigge , M L , Ivarsdottir , E V , Bjornsdottir , G , Holm , H , Thorgeirsson , G , Rafnar , T , Jonsdottir , I , Ingvarsson , T , Jonsson , H , Sulem , P , Thorsteinsdottir , U , Gudbjartsson , D F , Stefansson , K , Thorgeirsson , G & Ingvarsson , Þ 2021 , ' The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland ' , Arthritis and Rheumatology , vol. 73 , no. 11 , pp. 2025-2034 . https://doi.org/10.1002/art.41793 2326-5191 70007997 56f52596-b2fd-49d7-b254-788bc1f42ab2 ORCID: /0000-0002-3806-2296/work/123415629 85114618454 33982893 000700560500001 unpaywall: 10.1002/art.41793 https://hdl.handle.net/20.500.11815/4321 doi:10.1002/art.41793 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/432110.1002/art.41793 |
container_title |
Arthritis & Rheumatology |
container_volume |
73 |
container_issue |
11 |
container_start_page |
2025 |
op_container_end_page |
2034 |
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1786840887693672448 |
spelling |
ftopinvisindi:oai:opinvisindi.is:20.500.11815/4321 2023-12-31T10:08:14+01:00 The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland Styrkarsdottir, Unnur Lund, S.H. Saevarsdottir, S. Magnusson, M.I. Gunnarsdottir, K. Norddahl, Gudmundur L. Frigge, Michael L. Ivarsdottir, E.V. Bjornsdottir, Gyda Holm, Hilma Thorgeirsson, Guðmundur Rafnar, T. Jonsdottir, I. Ingvarsson, T. Jonsson, H. Sulem, P. Thorsteinsdottir, U. Gudbjartsson, Daniel Fannar Stefansson, K. Thorgeirsson, Gudmundur Ingvarsson, Þorvaldur Faculty of Physical Sciences Faculty of Medicine Internal Medicine and Emergency Services Faculty of Earth Sciences Clinical Laboratory Services, Diagnostics and Blood Bank Health Sciences School of Health Sciences Landspitali - The National University Hospital of Iceland 2021-11 10 805652 2025-2034 https://hdl.handle.net/20.500.11815/4321 https://doi.org/10.1002/art.41793 en eng Arthritis and Rheumatology; 73(11) http://www.scopus.com/inward/record.url?eid=2-s2.0-85114618454&partnerID=MN8TOARS http://www.scopus.com/inward/record.url?scp=85114618454&partnerID=8YFLogxK Styrkarsdottir , U , Lund , S H , Saevarsdottir , S , Magnusson , M I , Gunnarsdottir , K , Norddahl , G L , Frigge , M L , Ivarsdottir , E V , Bjornsdottir , G , Holm , H , Thorgeirsson , G , Rafnar , T , Jonsdottir , I , Ingvarsson , T , Jonsson , H , Sulem , P , Thorsteinsdottir , U , Gudbjartsson , D F , Stefansson , K , Thorgeirsson , G & Ingvarsson , Þ 2021 , ' The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland ' , Arthritis and Rheumatology , vol. 73 , no. 11 , pp. 2025-2034 . https://doi.org/10.1002/art.41793 2326-5191 70007997 56f52596-b2fd-49d7-b254-788bc1f42ab2 ORCID: /0000-0002-3806-2296/work/123415629 85114618454 33982893 000700560500001 unpaywall: 10.1002/art.41793 https://hdl.handle.net/20.500.11815/4321 doi:10.1002/art.41793 info:eu-repo/semantics/openAccess Liðskiptaaðgerðir Prótín Slitgigt Adult Aged Arthroplasty Replacement Biomarkers/blood Calcium-Binding Proteins/blood Case-Control Studies Disease Progression Female Humans Iceland Male Middle Aged Osteoarthritis/blood Prospective Studies Proteomics /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2021 ftopinvisindi https://doi.org/20.500.11815/432110.1002/art.41793 2023-12-06T23:55:19Z Funding Information: The study is sponsored by deCODE genetics, Inc./Amgen Inc. The authors independently collected the data, interpreted the results, and had the final decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Amgen. Publisher Copyright: © 2021 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case–control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement. Results: Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95% confidence interval 1.41–1.52] for knee OA, odds ratio 1.36 [95% confidence interval 1.29–1.43] for hip OA, and odds ratio 1.33 [95% confidence interval 1.26–1.40] for hand OA) and progression to joint replacement (hazard ratio 1.40 [95% confidence interval 1.30–1.51] for knee replacement and hazard ratio 1.31 [95% confidence interval 1.19–1.45] for hip replacement). Patients with OA who were in the highest quintile of risk of joint replacement, based on known risk factors (i.e., age, sex, and body mass index) and plasma CRTAC1 level, were 16 times more likely to undergo knee replacement within 5 years of plasma sample collection than those in the lowest quintile, and 6.5 times more likely to undergo hip replacement. CRTAC1 was not associated with other types of inflammatory arthritis. A specific protein ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Arthritis & Rheumatology 73 11 2025 2034 |