Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland
Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the ERA. Background: Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1-5 in Iceland, based o...
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/3912 2023-11-12T04:19:11+01:00 Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland Jónsson, Arnar Jan Lund, Sigrún Helga Eriksen, Bjorn O. Pálsson, Runólfur Indriðason, Ólafur Skúli Faculty of Physical Sciences Other departments Faculty of Medicine Office of Division of Clinical Services I Landspitali - The National University Hospital of Iceland 2022-07-01 10 1072472 1290-1299 https://hdl.handle.net/20.500.11815/3912 https://doi.org/10.1093/ckj/sfac051 en eng Clinical Kidney Journal; 15(7) http://www.scopus.com/inward/record.url?scp=85142650005&partnerID=8YFLogxK Jónsson , A J , Lund , S H , Eriksen , B O , Pálsson , R & Indriðason , Ó S 2022 , ' Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland ' , Clinical Kidney Journal , vol. 15 , no. 7 , pp. 1290-1299 . https://doi.org/10.1093/ckj/sfac051 2048-8505 48345823 ce1da904-098e-444b-8c2a-5d35ef187599 000786294000001 35756731 unpaywall: 10.1093/ckj/sfac051 85142650005 https://hdl.handle.net/20.500.11815/3912 doi:10.1093/ckj/sfac051 info:eu-repo/semantics/openAccess Nýrnalæknisfræði Nýrnasjúkdómar chronic kidney disease eGFR incidence KDIGO criteria risk factors Nephrology Transplantation /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2022 ftopinvisindi https://doi.org/20.500.11815/391210.1093/ckj/sfac051 2023-11-01T23:55:25Z Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the ERA. Background: Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1-5 in Iceland, based on multiple markers of kidney damage. Methods: All serum creatinine (SCr) values, urine protein measurements and diagnosis codes for kidney diseases and comorbid conditions for people aged ≥18 years were obtained from electronic medical records of all healthcare institutions in Iceland in 2008-2016. CKD was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria as evidence for kidney damage and/or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 for >3 months. Alternatively, CKD was defined using age-adapted eGFR thresholds. Mean annual age-standardized incidence of CKD was calculated for persons without CKD at study entry. Risk factor assessment was based on International Classification of Diseases diagnosis codes. Incidence was reported per 100 000 population. Results: We retrieved 1 820 990 SCr values for 206 727 persons. Median age was 45 years (range, 18-106) and 47% were men. Mean annual age-standardized incidence of CKD per 100 000 was 649 in men and 694 in women, and 480 in men and 522 in women using age-adapted eGFR thresholds. The incidence reached over 3000 in men and women aged >75 years. Traditional CKD risk factors, such as acute kidney injury, diabetes, hypertension and cardiovascular disease, as well as less well characterized risk factors, including chronic lung disease, malignancy and major psychiatric illness were associated with increased risk of CKD, and the same was true for obesity and sleep apnoea in women. Conclusion: The annual incidence of CKD, with strict adherence to the KDIGO criteria, was <0.7% but markedly lower using age-adapted eGFR thresholds. Apart from acute kidney injury, the observed risk factors comprised chronic and ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Clinical Kidney Journal 15 7 1290 1299 |
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Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Nýrnalæknisfræði Nýrnasjúkdómar chronic kidney disease eGFR incidence KDIGO criteria risk factors Nephrology Transplantation |
spellingShingle |
Nýrnalæknisfræði Nýrnasjúkdómar chronic kidney disease eGFR incidence KDIGO criteria risk factors Nephrology Transplantation Jónsson, Arnar Jan Lund, Sigrún Helga Eriksen, Bjorn O. Pálsson, Runólfur Indriðason, Ólafur Skúli Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland |
topic_facet |
Nýrnalæknisfræði Nýrnasjúkdómar chronic kidney disease eGFR incidence KDIGO criteria risk factors Nephrology Transplantation |
description |
Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the ERA. Background: Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1-5 in Iceland, based on multiple markers of kidney damage. Methods: All serum creatinine (SCr) values, urine protein measurements and diagnosis codes for kidney diseases and comorbid conditions for people aged ≥18 years were obtained from electronic medical records of all healthcare institutions in Iceland in 2008-2016. CKD was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria as evidence for kidney damage and/or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 for >3 months. Alternatively, CKD was defined using age-adapted eGFR thresholds. Mean annual age-standardized incidence of CKD was calculated for persons without CKD at study entry. Risk factor assessment was based on International Classification of Diseases diagnosis codes. Incidence was reported per 100 000 population. Results: We retrieved 1 820 990 SCr values for 206 727 persons. Median age was 45 years (range, 18-106) and 47% were men. Mean annual age-standardized incidence of CKD per 100 000 was 649 in men and 694 in women, and 480 in men and 522 in women using age-adapted eGFR thresholds. The incidence reached over 3000 in men and women aged >75 years. Traditional CKD risk factors, such as acute kidney injury, diabetes, hypertension and cardiovascular disease, as well as less well characterized risk factors, including chronic lung disease, malignancy and major psychiatric illness were associated with increased risk of CKD, and the same was true for obesity and sleep apnoea in women. Conclusion: The annual incidence of CKD, with strict adherence to the KDIGO criteria, was <0.7% but markedly lower using age-adapted eGFR thresholds. Apart from acute kidney injury, the observed risk factors comprised chronic and ... |
author2 |
Faculty of Physical Sciences Other departments Faculty of Medicine Office of Division of Clinical Services I Landspitali - The National University Hospital of Iceland |
format |
Article in Journal/Newspaper |
author |
Jónsson, Arnar Jan Lund, Sigrún Helga Eriksen, Bjorn O. Pálsson, Runólfur Indriðason, Ólafur Skúli |
author_facet |
Jónsson, Arnar Jan Lund, Sigrún Helga Eriksen, Bjorn O. Pálsson, Runólfur Indriðason, Ólafur Skúli |
author_sort |
Jónsson, Arnar Jan |
title |
Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland |
title_short |
Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland |
title_full |
Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland |
title_fullStr |
Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland |
title_full_unstemmed |
Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland |
title_sort |
incidence of and risk factors of chronic kidney disease: results of a nationwide study in iceland |
publishDate |
2022 |
url |
https://hdl.handle.net/20.500.11815/3912 https://doi.org/10.1093/ckj/sfac051 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Clinical Kidney Journal; 15(7) http://www.scopus.com/inward/record.url?scp=85142650005&partnerID=8YFLogxK Jónsson , A J , Lund , S H , Eriksen , B O , Pálsson , R & Indriðason , Ó S 2022 , ' Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland ' , Clinical Kidney Journal , vol. 15 , no. 7 , pp. 1290-1299 . https://doi.org/10.1093/ckj/sfac051 2048-8505 48345823 ce1da904-098e-444b-8c2a-5d35ef187599 000786294000001 35756731 unpaywall: 10.1093/ckj/sfac051 85142650005 https://hdl.handle.net/20.500.11815/3912 doi:10.1093/ckj/sfac051 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/391210.1093/ckj/sfac051 |
container_title |
Clinical Kidney Journal |
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15 |
container_issue |
7 |
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1290 |
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1299 |
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