Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by high rates of co-morbid psychopathology. Randomized controlled trials of multimodal interventions, combining pharmacological and psychological treatments, have shown a robust treatment effect for ADHD s...
Published in: | Psychological Medicine |
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Online Access: | https://hdl.handle.net/20.500.11815/3620 https://doi.org/10.1017/S0033291715000756 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/3620 2023-11-12T04:19:33+01:00 Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. Young, S Khondoker, M Emilsson, Brynjar Sigurðsson, Jón F Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, Halldora Gudjonsson, Gisli H. Department of Psychology Faculty of Medicine Women's and Childrens's Services Landspitali - The National University Hospital of Iceland 2015-05-29 292598 researchoutputwizard: hdl.handle.net/2336/561260 https://hdl.handle.net/20.500.11815/3620 https://doi.org/10.1017/S0033291715000756 en eng Psychological Medicine; () http://dx.doi.org/10.1017/S0033291715000756 Young , S , Khondoker , M , Emilsson , B , Sigurðsson , J F , Philipp-Wiegmann , F , Baldursson , G , Olafsdottir , H & Gudjonsson , G H 2015 , ' Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. ' , Psychological Medicine . https://doi.org/10.1017/S0033291715000756 1469-8978 49125502 9539ae02-5831-4746-ab27-83fb94014b4f researchoutputwizard: hdl.handle.net/2336/561260 26022103 84941261630 https://hdl.handle.net/20.500.11815/3620 doi:10.1017/S0033291715000756 info:eu-repo/semantics/openAccess Sálfræði Barna- og unglingageðlæknisfræði Geðsjúkdómafræði ADHD Hugræn atferlismeðferð Lyfjameðferð Attention Deficit Disorder with Hyperactivity/drug therapy* Cognitive Therapy/methods Rehabilitation /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2015 ftopinvisindi https://doi.org/20.500.11815/362010.1017/S0033291715000756 2023-11-01T23:55:24Z Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by high rates of co-morbid psychopathology. Randomized controlled trials of multimodal interventions, combining pharmacological and psychological treatments, have shown a robust treatment effect for ADHD symptoms but outcomes for co-morbid symptoms have been mixed. This may be accounted for by the type of intervention selected and/or by methodological problems including lack of follow-up and low power. The current study addressed these limitations in a parallel-group randomized controlled trial conducted in Iceland. A total of 95 adult ADHD patients who were already being treated with medication (MED) were randomly assigned to receive treatment as usual (TAU/MED) or 15 sessions of cognitive-behavioural therapy (CBT/MED) using the R&R2ADHD intervention which employs both group and individual modalities. Primary measures of ADHD symptoms and severity of illness, and secondary measures of anxiety, depression and quality of life were given at baseline, end of treatment and 3-month follow-up. Primary outcomes were rated by clinicians blind to treatment condition assignment. CBT/MED showed overall (combined outcome at end of treatment and 3-month follow-up) significantly greater reduction in primary outcomes for clinician-rated and self-rated ADHD symptoms. Treatment effect of primary outcomes was maintained at follow-up, which suggests robust and lasting findings. In contrast to the primary outcomes, the secondary outcomes showed significant improvement over time. The study provides evidence for the effectiveness of R&R2ADHD and demonstrates that there are differential effects over time for ADHD symptoms versus co-morbid problems, the latter taking longer to show positive effects. Peer reviewed Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Psychological Medicine 45 13 2793 2804 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Sálfræði Barna- og unglingageðlæknisfræði Geðsjúkdómafræði ADHD Hugræn atferlismeðferð Lyfjameðferð Attention Deficit Disorder with Hyperactivity/drug therapy* Cognitive Therapy/methods Rehabilitation |
spellingShingle |
Sálfræði Barna- og unglingageðlæknisfræði Geðsjúkdómafræði ADHD Hugræn atferlismeðferð Lyfjameðferð Attention Deficit Disorder with Hyperactivity/drug therapy* Cognitive Therapy/methods Rehabilitation Young, S Khondoker, M Emilsson, Brynjar Sigurðsson, Jón F Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, Halldora Gudjonsson, Gisli H. Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. |
topic_facet |
Sálfræði Barna- og unglingageðlæknisfræði Geðsjúkdómafræði ADHD Hugræn atferlismeðferð Lyfjameðferð Attention Deficit Disorder with Hyperactivity/drug therapy* Cognitive Therapy/methods Rehabilitation |
description |
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by high rates of co-morbid psychopathology. Randomized controlled trials of multimodal interventions, combining pharmacological and psychological treatments, have shown a robust treatment effect for ADHD symptoms but outcomes for co-morbid symptoms have been mixed. This may be accounted for by the type of intervention selected and/or by methodological problems including lack of follow-up and low power. The current study addressed these limitations in a parallel-group randomized controlled trial conducted in Iceland. A total of 95 adult ADHD patients who were already being treated with medication (MED) were randomly assigned to receive treatment as usual (TAU/MED) or 15 sessions of cognitive-behavioural therapy (CBT/MED) using the R&R2ADHD intervention which employs both group and individual modalities. Primary measures of ADHD symptoms and severity of illness, and secondary measures of anxiety, depression and quality of life were given at baseline, end of treatment and 3-month follow-up. Primary outcomes were rated by clinicians blind to treatment condition assignment. CBT/MED showed overall (combined outcome at end of treatment and 3-month follow-up) significantly greater reduction in primary outcomes for clinician-rated and self-rated ADHD symptoms. Treatment effect of primary outcomes was maintained at follow-up, which suggests robust and lasting findings. In contrast to the primary outcomes, the secondary outcomes showed significant improvement over time. The study provides evidence for the effectiveness of R&R2ADHD and demonstrates that there are differential effects over time for ADHD symptoms versus co-morbid problems, the latter taking longer to show positive effects. Peer reviewed |
author2 |
Department of Psychology Faculty of Medicine Women's and Childrens's Services Landspitali - The National University Hospital of Iceland |
format |
Article in Journal/Newspaper |
author |
Young, S Khondoker, M Emilsson, Brynjar Sigurðsson, Jón F Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, Halldora Gudjonsson, Gisli H. |
author_facet |
Young, S Khondoker, M Emilsson, Brynjar Sigurðsson, Jón F Philipp-Wiegmann, F. Baldursson, Gísli Olafsdottir, Halldora Gudjonsson, Gisli H. |
author_sort |
Young, S |
title |
Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. |
title_short |
Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. |
title_full |
Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. |
title_fullStr |
Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. |
title_full_unstemmed |
Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. |
title_sort |
cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. |
publishDate |
2015 |
url |
https://hdl.handle.net/20.500.11815/3620 https://doi.org/10.1017/S0033291715000756 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Psychological Medicine; () http://dx.doi.org/10.1017/S0033291715000756 Young , S , Khondoker , M , Emilsson , B , Sigurðsson , J F , Philipp-Wiegmann , F , Baldursson , G , Olafsdottir , H & Gudjonsson , G H 2015 , ' Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. ' , Psychological Medicine . https://doi.org/10.1017/S0033291715000756 1469-8978 49125502 9539ae02-5831-4746-ab27-83fb94014b4f researchoutputwizard: hdl.handle.net/2336/561260 26022103 84941261630 https://hdl.handle.net/20.500.11815/3620 doi:10.1017/S0033291715000756 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/362010.1017/S0033291715000756 |
container_title |
Psychological Medicine |
container_volume |
45 |
container_issue |
13 |
container_start_page |
2793 |
op_container_end_page |
2804 |
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1782335953837228032 |