Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland
Funding Information: This study was supported by Landspitali University Hospital Science Fund. Publisher Copyright: © 2022 Acta Anaesthesiologica Scandinavica Foundation. Objectives: All SARS-CoV-2-positive persons in Iceland were prospectively monitored and those who required outpatient evaluation...
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Online Access: | https://hdl.handle.net/20.500.11815/3498 https://doi.org/10.1111/aas.14109 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/3498 2023-11-12T04:19:04+01:00 Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland Oskarsdottir, Thora Sigurðsson, Martin Ingi Pálsson, Runólfur Eythorsson, E. Perioperative Services Faculty of Medicine Other departments Landspitali - The National University Hospital of Iceland 2022-07-29 9 561934 969-977 https://hdl.handle.net/20.500.11815/3498 https://doi.org/10.1111/aas.14109 en eng Acta Anaesthesiologica Scandinavica; 66(8) http://www.scopus.com/inward/record.url?scp=85135103394&partnerID=8YFLogxK Oskarsdottir , T , Sigurðsson , M I , Pálsson , R & Eythorsson , E 2022 , ' Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland ' , Acta Anaesthesiologica Scandinavica , vol. 66 , no. 8 , pp. 969-977 . https://doi.org/10.1111/aas.14109 0001-5172 60493159 c76aeb96-3163-4a73-8968-faf72776e0b8 85135103394 35748857 unpaywall: 10.1111/aas.14109 https://hdl.handle.net/20.500.11815/3498 doi:10.1111/aas.14109 info:eu-repo/semantics/openAccess Svæfinga- og gjörgæslulæknisfræði Nýrnalæknisfræði ambulatory care COVID-19 critical care laboratory markers outcome SARS-CoV-2 Humans Biomarkers C-Reactive Protein/analysis Iceland/epidemiology Retrospective Studies Ferritins Anesthesiology and Pain Medicine /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2022 ftopinvisindi https://doi.org/20.500.11815/349810.1111/aas.14109 2023-11-01T23:55:22Z Funding Information: This study was supported by Landspitali University Hospital Science Fund. Publisher Copyright: © 2022 Acta Anaesthesiologica Scandinavica Foundation. Objectives: All SARS-CoV-2-positive persons in Iceland were prospectively monitored and those who required outpatient evaluation or were admitted to hospital underwent protocolized evaluation that included a standardized panel of biomarkers. The aim was to describe longitudinal changes in inflammatory biomarkers throughout the infection period of patients with COVID-19 requiring different levels of care. Design: Registry-based study. Setting: Nationwide study in Iceland. Patients: All individuals who tested positive for SARS-CoV-2 by real-time polymerase chain reaction (RT-PCR) from February 28 to December 31, 2020 in Iceland and had undergone blood tests between 5 days before and 21 days following onset of symptoms. Measurements and Main Results: Data were collected from the electronic medical record system of Landspitali–The National University Hospital of Iceland. Data analyses were descriptive and the evolution of biomarkers was visualized using locally weighted scatterplot smoothing curves stratified by the worst clinical outcome experienced by the patient: outpatient evaluation only, hospitalization, and either intensive care unit (ICU) admission or death. Of 571 included patients, 310 (54.3%) only required outpatient evaluation or treatment, 202 (35.4%) were hospitalized, and 59 (10.3%) were either admitted to the ICU or died. An early and persistent separation of the mean lymphocyte count and plasma C-reactive protein (CRP) and ferritin levels was observed between the three outcome groups, which occurred prior to hospitalization for those who later were admitted to ICU or died. Lower lymphocyte count, and higher CRP and ferritin levels correlated with worse clinical outcomes. Patients who were either admitted to the ICU or died had sustained higher white blood cell and neutrophil counts, and elevated plasma levels of procalcitonin and ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Acta Anaesthesiologica Scandinavica 66 8 969 977 |
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Opin vísindi (Iceland) |
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ftopinvisindi |
language |
English |
topic |
Svæfinga- og gjörgæslulæknisfræði Nýrnalæknisfræði ambulatory care COVID-19 critical care laboratory markers outcome SARS-CoV-2 Humans Biomarkers C-Reactive Protein/analysis Iceland/epidemiology Retrospective Studies Ferritins Anesthesiology and Pain Medicine |
spellingShingle |
Svæfinga- og gjörgæslulæknisfræði Nýrnalæknisfræði ambulatory care COVID-19 critical care laboratory markers outcome SARS-CoV-2 Humans Biomarkers C-Reactive Protein/analysis Iceland/epidemiology Retrospective Studies Ferritins Anesthesiology and Pain Medicine Oskarsdottir, Thora Sigurðsson, Martin Ingi Pálsson, Runólfur Eythorsson, E. Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland |
topic_facet |
Svæfinga- og gjörgæslulæknisfræði Nýrnalæknisfræði ambulatory care COVID-19 critical care laboratory markers outcome SARS-CoV-2 Humans Biomarkers C-Reactive Protein/analysis Iceland/epidemiology Retrospective Studies Ferritins Anesthesiology and Pain Medicine |
description |
Funding Information: This study was supported by Landspitali University Hospital Science Fund. Publisher Copyright: © 2022 Acta Anaesthesiologica Scandinavica Foundation. Objectives: All SARS-CoV-2-positive persons in Iceland were prospectively monitored and those who required outpatient evaluation or were admitted to hospital underwent protocolized evaluation that included a standardized panel of biomarkers. The aim was to describe longitudinal changes in inflammatory biomarkers throughout the infection period of patients with COVID-19 requiring different levels of care. Design: Registry-based study. Setting: Nationwide study in Iceland. Patients: All individuals who tested positive for SARS-CoV-2 by real-time polymerase chain reaction (RT-PCR) from February 28 to December 31, 2020 in Iceland and had undergone blood tests between 5 days before and 21 days following onset of symptoms. Measurements and Main Results: Data were collected from the electronic medical record system of Landspitali–The National University Hospital of Iceland. Data analyses were descriptive and the evolution of biomarkers was visualized using locally weighted scatterplot smoothing curves stratified by the worst clinical outcome experienced by the patient: outpatient evaluation only, hospitalization, and either intensive care unit (ICU) admission or death. Of 571 included patients, 310 (54.3%) only required outpatient evaluation or treatment, 202 (35.4%) were hospitalized, and 59 (10.3%) were either admitted to the ICU or died. An early and persistent separation of the mean lymphocyte count and plasma C-reactive protein (CRP) and ferritin levels was observed between the three outcome groups, which occurred prior to hospitalization for those who later were admitted to ICU or died. Lower lymphocyte count, and higher CRP and ferritin levels correlated with worse clinical outcomes. Patients who were either admitted to the ICU or died had sustained higher white blood cell and neutrophil counts, and elevated plasma levels of procalcitonin and ... |
author2 |
Perioperative Services Faculty of Medicine Other departments Landspitali - The National University Hospital of Iceland |
format |
Article in Journal/Newspaper |
author |
Oskarsdottir, Thora Sigurðsson, Martin Ingi Pálsson, Runólfur Eythorsson, E. |
author_facet |
Oskarsdottir, Thora Sigurðsson, Martin Ingi Pálsson, Runólfur Eythorsson, E. |
author_sort |
Oskarsdottir, Thora |
title |
Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland |
title_short |
Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland |
title_full |
Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland |
title_fullStr |
Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland |
title_full_unstemmed |
Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland |
title_sort |
longitudinal changes in inflammatory biomarkers among patients with covid-19 : a nationwide study in iceland |
publishDate |
2022 |
url |
https://hdl.handle.net/20.500.11815/3498 https://doi.org/10.1111/aas.14109 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Acta Anaesthesiologica Scandinavica; 66(8) http://www.scopus.com/inward/record.url?scp=85135103394&partnerID=8YFLogxK Oskarsdottir , T , Sigurðsson , M I , Pálsson , R & Eythorsson , E 2022 , ' Longitudinal changes in inflammatory biomarkers among patients with COVID-19 : A nationwide study in Iceland ' , Acta Anaesthesiologica Scandinavica , vol. 66 , no. 8 , pp. 969-977 . https://doi.org/10.1111/aas.14109 0001-5172 60493159 c76aeb96-3163-4a73-8968-faf72776e0b8 85135103394 35748857 unpaywall: 10.1111/aas.14109 https://hdl.handle.net/20.500.11815/3498 doi:10.1111/aas.14109 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/349810.1111/aas.14109 |
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Acta Anaesthesiologica Scandinavica |
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