Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors
Background Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most...
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Online Access: | https://hdl.handle.net/20.500.11815/336 https://doi.org/10.1371/journal.pmed.1002296 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/336 2023-05-15T16:48:02+02:00 Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F. Olsen, Jørgen H. Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland 2017-05-09 e1002296 https://hdl.handle.net/20.500.11815/336 https://doi.org/10.1371/journal.pmed.1002296 en eng Public Library of Science (PLoS) Plos Medicine;14(5) de Fine Licht S, Rugbjerg K, Gudmundsdottir T, Bonnesen TG, Asdahl PH, et al. (2017) Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors. PLOS Medicine 14(5): e1002296. https://doi.org/10.1371/journal.pmed.1002296 1549-1277 1549-1676 (eISSN) https://hdl.handle.net/20.500.11815/336 Plos Medicine doi:10.1371/journal.pmed.1002296 info:eu-repo/semantics/openAccess Krabbamein Krabbameinssjúklingar Börn Fullorðnir Heilsufar info:eu-repo/semantics/article 2017 ftopinvisindi https://doi.org/20.500.11815/336 https://doi.org/10.1371/journal.pmed.1002296 2022-11-18T06:51:31Z Background Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Methods and findings From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943–2008 in Denmark, 1971–2008 in Finland, 1955–2008 in Iceland, and 1958–2008 in Sweden. We randomly selected 152,231 population comparison individuals matched by age, sex, year, and country (or municipality in Sweden) from the national population registers. Using a cohort design, study participants were followed in the national hospital registers in Denmark, 1977–2010; Finland, 1975–2012; Iceland, 1999–2008; and Sweden, 1968–2009. Disease-specific hospitalisation rates in survivors and comparison individuals were used to calculate survivors’ standardised hospitalisation rate ratios (RRs), absolute excess risks (AERs), and standardised bed day ratios (SBDRs) based on length of stay in hospital. We adjusted for sex, age, and year by indirect standardisation. During 336,554 person-years of follow-up (mean: 16 years; range: 0–42 years), childhood cancer survivors experienced 21,325 first hospitalisations for diseases in one or more of 120 disease categories (cancer recurrence not included), when 10,999 were expected, yielding an overall RR of 1.94 (95% confidence interval [95% CI] 1.91–1.97). The AER was 3,068 (2,980–3,156) per 100,000 person-years, meaning that for each additional year of follow-up, an average of 3 of 100 survivors were hospitalised for a new excess disease beyond the background rates. Approximately 50% of the excess hospitalisations were for diseases of the nervous system (19.1% of all excess ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) PLOS Medicine 14 5 e1002296 |
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Opin vísindi (Iceland) |
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ftopinvisindi |
language |
English |
topic |
Krabbamein Krabbameinssjúklingar Börn Fullorðnir Heilsufar |
spellingShingle |
Krabbamein Krabbameinssjúklingar Börn Fullorðnir Heilsufar de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F. Olsen, Jørgen H. Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors |
topic_facet |
Krabbamein Krabbameinssjúklingar Börn Fullorðnir Heilsufar |
description |
Background Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Methods and findings From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943–2008 in Denmark, 1971–2008 in Finland, 1955–2008 in Iceland, and 1958–2008 in Sweden. We randomly selected 152,231 population comparison individuals matched by age, sex, year, and country (or municipality in Sweden) from the national population registers. Using a cohort design, study participants were followed in the national hospital registers in Denmark, 1977–2010; Finland, 1975–2012; Iceland, 1999–2008; and Sweden, 1968–2009. Disease-specific hospitalisation rates in survivors and comparison individuals were used to calculate survivors’ standardised hospitalisation rate ratios (RRs), absolute excess risks (AERs), and standardised bed day ratios (SBDRs) based on length of stay in hospital. We adjusted for sex, age, and year by indirect standardisation. During 336,554 person-years of follow-up (mean: 16 years; range: 0–42 years), childhood cancer survivors experienced 21,325 first hospitalisations for diseases in one or more of 120 disease categories (cancer recurrence not included), when 10,999 were expected, yielding an overall RR of 1.94 (95% confidence interval [95% CI] 1.91–1.97). The AER was 3,068 (2,980–3,156) per 100,000 person-years, meaning that for each additional year of follow-up, an average of 3 of 100 survivors were hospitalised for a new excess disease beyond the background rates. Approximately 50% of the excess hospitalisations were for diseases of the nervous system (19.1% of all excess ... |
author2 |
Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland |
format |
Article in Journal/Newspaper |
author |
de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F. Olsen, Jørgen H. |
author_facet |
de Fine Licht, Sofie Rugbjerg, Kathrine Gudmundsdottir, Thorgerdur Bonnesen, Trine G. Asdahl, Peter Haubjerg Holmqvist, Anna Sällfors Madanat-Harjuoja, Laura Tryggvadottir, Laufey Wesenberg, Finn Hasle, Henrik Winther, Jeanette F. Olsen, Jørgen H. |
author_sort |
de Fine Licht, Sofie |
title |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors |
title_short |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors |
title_full |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors |
title_fullStr |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors |
title_full_unstemmed |
Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors |
title_sort |
long-term inpatient disease burden in the adult life after childhood cancer in scandinavia (aliccs) study: a cohort study of 21,297 childhood cancer survivors |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://hdl.handle.net/20.500.11815/336 https://doi.org/10.1371/journal.pmed.1002296 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Plos Medicine;14(5) de Fine Licht S, Rugbjerg K, Gudmundsdottir T, Bonnesen TG, Asdahl PH, et al. (2017) Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors. PLOS Medicine 14(5): e1002296. https://doi.org/10.1371/journal.pmed.1002296 1549-1277 1549-1676 (eISSN) https://hdl.handle.net/20.500.11815/336 Plos Medicine doi:10.1371/journal.pmed.1002296 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/336 https://doi.org/10.1371/journal.pmed.1002296 |
container_title |
PLOS Medicine |
container_volume |
14 |
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5 |
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e1002296 |
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1766038130287181824 |