Effect of doxycycline microencapsulation on buccal films : Stability, mucoadhesion and in vitro drug release

Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This research was funded by Rannsóknarsjóður Háskóla Íslands (University of Iceland Research Grand). The aim of this work was to stabilize doxycycline in mucoadhesive buccal films at room temperature (25◦C). Since doxycyc...

Full description

Bibliographic Details
Published in:Gels
Main Authors: Patlolla, Venu Gopal Reddy, Popovic, Nikolina, Peter Holbrook, William, Kristmundsdottir, Thordis, Gizurarson, Sveinbjörn
Other Authors: Faculty of Pharmaceutical Sciences
Format: Article in Journal/Newspaper
Language:English
Published: 2021
Subjects:
Doxycycline
Film
Matrix metalloproteinase inhibitor
Microparticles
MMPI
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
Iceland
Online Access:https://hdl.handle.net/20.500.11815/3262
https://doi.org/10.3390/gels7020051
Description
Summary:Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This research was funded by Rannsóknarsjóður Háskóla Íslands (University of Iceland Research Grand). The aim of this work was to stabilize doxycycline in mucoadhesive buccal films at room temperature (25◦C). Since doxycycline is susceptible to degradation such as oxidation and epimerization, tablets are currently the only formulation that can keep the drug fully stable at room temperature, while liquid formulations are limited to refrigerated conditions (4◦C). In this study, the aim was to make formulations containing subclinical (antibiotic) doxycycline concentration that can act as matrix metalloproteinase inhibitors (MMPI) and can be stored at temperatures such as 25◦C. Here, doxycycline was complexed with excipients using three techniques and entrapped into microparticles that were stored at 4◦C, 25◦C and 40◦C. Effect of addition of precomplexed doxycycline microparticles on films: stability mucoadhesion capacity, tensile strength, swelling index and in vitro release was studied. The complexation efficiency between drug-excipients, microparticles and films was studied using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Two of the films were found to be stable at 4◦C but the film containing microparticle composed of precomplexed doxycycline with β-cyclodextrin, MgCl2, sodium thiosulfate, HPMC and Eudragit® RS 12.5 was found to be stable at 25◦C until 26 weeks. The addition of microparticles to the films was found to reduce the mucoadhesive capacity, peak detachment force, tensile strength and elasticity, but improved the stability at room temperature. Peer reviewed

Similar Items