Sepsis requiring Intensive Care Unit admission
Sepsis is a leading cause of admission to intensive care units (ICU) worldwide and mortality rates remain high despite advances in organ support. Awareness of the syndrome has increased substantially in the past 20 years, after the publication of several studies that showed improved outcome with rel...
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University of Iceland, School of Health Sciences, Faculty of Medicine
2022
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Online Access: | https://hdl.handle.net/20.500.11815/3162 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/3162 2023-05-15T16:48:02+02:00 Sepsis requiring Intensive Care Unit admission Studies on temporal trends in epidemiology, cancer, elective surgery and local infectious outbreaks Vésteinsdóttir, Edda Sigurbergur Kárason Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland 2022-05 https://hdl.handle.net/20.500.11815/3162 en eng University of Iceland, School of Health Sciences, Faculty of Medicine 978-9935-25-173-2 https://hdl.handle.net/20.500.11815/3162 info:eu-repo/semantics/closedAccess Faraldsfræði Gjörgæslulækningar Krabbamein Hjartaaðgerðir Doktorsritgerðir Epidemiology Cardiology Oncology Critical care outcomes Elective surgical procedures Cardiac surgical procedures info:eu-repo/semantics/doctoralThesis 2022 ftopinvisindi https://doi.org/20.500.11815/3162 2022-11-18T06:52:20Z Sepsis is a leading cause of admission to intensive care units (ICU) worldwide and mortality rates remain high despite advances in organ support. Awareness of the syndrome has increased substantially in the past 20 years, after the publication of several studies that showed improved outcome with relatively simple measures, such as early administration of fluid and antibiotics. These studies were the impetus for an educational treatment campaign with the goal of reducing mortality from sepsis. Several studies in recent years have shown an increasing incidence of sepsis, and declining mortality rates. Many of those are based on diagnosis codes with risk of bias due to increased use of sepsis codes as a result of this heightened awareness of sepsis. Medical care may contribute to the development of sepsis, not only by weakening host defences with immunosuppressive therapy and surgical procedures, but also on rarer occasions by contamination, highlighting the importance of scrutinous observation of hospital-acquired infections. The overall aim of this thesis was to create a broad overview of sepsis requiring admission to intensive care units in a nationwide cohort in Iceland, with a special focus on several patient groups. Trends in incidence, treatment and outcome were assessed, with special consideration given to cancer patients with sepsis, patients developing sepsis after surgery and the detection of nosocomial infection clusters and their impact. The four studies (I-IV) were retrospective cohort studies using two cohorts of patients. For the first cohort, all ICU admissions in Iceland were screened for the presence of severe sepsis or septic shock on admission during calendar years 2006, 2008, 2010, 2012, 2014 and 2016 using clinical criteria and chart review. This database of sepsis patients (971 patients) was used in studies I,II and III. Additionally, for study III, the number and type of all surgical procedures performed at the largest hospital in Iceland, Landspitali, during the same study years were ... Doctoral or Postdoctoral Thesis Iceland Opin vísindi (Iceland) |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Faraldsfræði Gjörgæslulækningar Krabbamein Hjartaaðgerðir Doktorsritgerðir Epidemiology Cardiology Oncology Critical care outcomes Elective surgical procedures Cardiac surgical procedures |
spellingShingle |
Faraldsfræði Gjörgæslulækningar Krabbamein Hjartaaðgerðir Doktorsritgerðir Epidemiology Cardiology Oncology Critical care outcomes Elective surgical procedures Cardiac surgical procedures Vésteinsdóttir, Edda Sepsis requiring Intensive Care Unit admission |
topic_facet |
Faraldsfræði Gjörgæslulækningar Krabbamein Hjartaaðgerðir Doktorsritgerðir Epidemiology Cardiology Oncology Critical care outcomes Elective surgical procedures Cardiac surgical procedures |
description |
Sepsis is a leading cause of admission to intensive care units (ICU) worldwide and mortality rates remain high despite advances in organ support. Awareness of the syndrome has increased substantially in the past 20 years, after the publication of several studies that showed improved outcome with relatively simple measures, such as early administration of fluid and antibiotics. These studies were the impetus for an educational treatment campaign with the goal of reducing mortality from sepsis. Several studies in recent years have shown an increasing incidence of sepsis, and declining mortality rates. Many of those are based on diagnosis codes with risk of bias due to increased use of sepsis codes as a result of this heightened awareness of sepsis. Medical care may contribute to the development of sepsis, not only by weakening host defences with immunosuppressive therapy and surgical procedures, but also on rarer occasions by contamination, highlighting the importance of scrutinous observation of hospital-acquired infections. The overall aim of this thesis was to create a broad overview of sepsis requiring admission to intensive care units in a nationwide cohort in Iceland, with a special focus on several patient groups. Trends in incidence, treatment and outcome were assessed, with special consideration given to cancer patients with sepsis, patients developing sepsis after surgery and the detection of nosocomial infection clusters and their impact. The four studies (I-IV) were retrospective cohort studies using two cohorts of patients. For the first cohort, all ICU admissions in Iceland were screened for the presence of severe sepsis or septic shock on admission during calendar years 2006, 2008, 2010, 2012, 2014 and 2016 using clinical criteria and chart review. This database of sepsis patients (971 patients) was used in studies I,II and III. Additionally, for study III, the number and type of all surgical procedures performed at the largest hospital in Iceland, Landspitali, during the same study years were ... |
author2 |
Sigurbergur Kárason Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland |
format |
Doctoral or Postdoctoral Thesis |
author |
Vésteinsdóttir, Edda |
author_facet |
Vésteinsdóttir, Edda |
author_sort |
Vésteinsdóttir, Edda |
title |
Sepsis requiring Intensive Care Unit admission |
title_short |
Sepsis requiring Intensive Care Unit admission |
title_full |
Sepsis requiring Intensive Care Unit admission |
title_fullStr |
Sepsis requiring Intensive Care Unit admission |
title_full_unstemmed |
Sepsis requiring Intensive Care Unit admission |
title_sort |
sepsis requiring intensive care unit admission |
publisher |
University of Iceland, School of Health Sciences, Faculty of Medicine |
publishDate |
2022 |
url |
https://hdl.handle.net/20.500.11815/3162 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
978-9935-25-173-2 https://hdl.handle.net/20.500.11815/3162 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/20.500.11815/3162 |
_version_ |
1766038123451514880 |