Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure
Funding Information: Support statement: The Icelandic Bioethics Committee (VSN 99-069-V1-V2-S1) and the Icelandic Data Protection Authority (99080306) approved the study protocol. It was supported by grants from The Science Fund of Landspitali, University Hospital of Iceland, and from the Associatio...
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/3136 2023-11-12T04:19:05+01:00 Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure Haraldsdóttir, Sigríður Ólína Jonasson, Jon Gunnlaugur Jorundsdottir, Kristin Bara Hannesson, Haraldur Jon Gislason, Thorarinn Gudbjornsson, Bjorn Faculty of Medicine Clinical Laboratory Services, Diagnostics and Blood Bank Internal Medicine and Emergency Services Landspitali - The National University Hospital of Iceland 2021-10-01 731211 https://hdl.handle.net/20.500.11815/3136 https://doi.org/10.1183/23120541.00550-2021 en eng ERJ Open Research; 7(4) Haraldsdóttir , S Ó , Jonasson , J G , Jorundsdottir , K B , Hannesson , H J , Gislason , T & Gudbjornsson , B 2021 , ' Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure ' , ERJ Open Research , vol. 7 , no. 4 , 00550-2021 . https://doi.org/10.1183/23120541.00550-2021 2312-0541 48221662 c2aa60ab-c77f-421a-b625-88f257d372f0 85123548991 https://hdl.handle.net/20.500.11815/3136 doi:10.1183/23120541.00550-2021 info:eu-repo/semantics/openAccess Lungnalæknisfræði Meinafræði Svefnrannsóknir Gigtarlæknisfræði Sarklíki sarcoidosis environmental exposure Iceland Pulmonary and Respiratory Medicine /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2021 ftopinvisindi https://doi.org/20.500.11815/313610.1183/23120541.00550-2021 2023-11-01T23:55:18Z Funding Information: Support statement: The Icelandic Bioethics Committee (VSN 99-069-V1-V2-S1) and the Icelandic Data Protection Authority (99080306) approved the study protocol. It was supported by grants from The Science Fund of Landspitali, University Hospital of Iceland, and from the Association of Icelandic Pulmonologists. Publisher Copyright: © The authors 2021. Background This nationwide study aimed to elucidate the incidence and clinical characteristics of tissueverified sarcoidosis in Iceland. A secondary aim was to analyse sex differences and identify possible environmental factors contributing to the pathological process. Materials and methods This is a descriptive study covering 36 years ( January 1, 1981 through December 31, 2016). Histopathological reports and electronic hospital discharge registries were reviewed in context for granulomas and/or sarcoidosis. National data were used for comparison regarding smoking habits and occupation, adjusted for age, sex and year of diagnosis. The data were stored in FileMaker and calculations were made by extracting data from this database to the statistical software package R. Results A total of 418 patients (54% females) were diagnosed with tissue-verified sarcoidosis. The incidence rate was 4.15/100 000/year, similar among females and males. The mean age at diagnosis was higher among females (53.0±14.2 years) than males (48.2±13.8 years). Fatigue was the most frequent single symptom (49.7%), but when all respiratory symptoms were grouped, they were the most frequent symptoms (60%). No significant difference was found between smoking status and sarcoidosis. Possible hazardous exposure in the workplace was reported by 19.4% of the cases. Conclusion The incidence of sarcoidosis in Iceland was higher than in an Asian population where the same inclusion criteria were applied. The clinical picture diverges partly from that in the Asian population but resembles that among other Caucasians. Fatigue and respiratory symptoms were predominant. The biphasic pattern ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) ERJ Open Research 7 4 00550-2021 |
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Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
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English |
topic |
Lungnalæknisfræði Meinafræði Svefnrannsóknir Gigtarlæknisfræði Sarklíki sarcoidosis environmental exposure Iceland Pulmonary and Respiratory Medicine |
spellingShingle |
Lungnalæknisfræði Meinafræði Svefnrannsóknir Gigtarlæknisfræði Sarklíki sarcoidosis environmental exposure Iceland Pulmonary and Respiratory Medicine Haraldsdóttir, Sigríður Ólína Jonasson, Jon Gunnlaugur Jorundsdottir, Kristin Bara Hannesson, Haraldur Jon Gislason, Thorarinn Gudbjornsson, Bjorn Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure |
topic_facet |
Lungnalæknisfræði Meinafræði Svefnrannsóknir Gigtarlæknisfræði Sarklíki sarcoidosis environmental exposure Iceland Pulmonary and Respiratory Medicine |
description |
Funding Information: Support statement: The Icelandic Bioethics Committee (VSN 99-069-V1-V2-S1) and the Icelandic Data Protection Authority (99080306) approved the study protocol. It was supported by grants from The Science Fund of Landspitali, University Hospital of Iceland, and from the Association of Icelandic Pulmonologists. Publisher Copyright: © The authors 2021. Background This nationwide study aimed to elucidate the incidence and clinical characteristics of tissueverified sarcoidosis in Iceland. A secondary aim was to analyse sex differences and identify possible environmental factors contributing to the pathological process. Materials and methods This is a descriptive study covering 36 years ( January 1, 1981 through December 31, 2016). Histopathological reports and electronic hospital discharge registries were reviewed in context for granulomas and/or sarcoidosis. National data were used for comparison regarding smoking habits and occupation, adjusted for age, sex and year of diagnosis. The data were stored in FileMaker and calculations were made by extracting data from this database to the statistical software package R. Results A total of 418 patients (54% females) were diagnosed with tissue-verified sarcoidosis. The incidence rate was 4.15/100 000/year, similar among females and males. The mean age at diagnosis was higher among females (53.0±14.2 years) than males (48.2±13.8 years). Fatigue was the most frequent single symptom (49.7%), but when all respiratory symptoms were grouped, they were the most frequent symptoms (60%). No significant difference was found between smoking status and sarcoidosis. Possible hazardous exposure in the workplace was reported by 19.4% of the cases. Conclusion The incidence of sarcoidosis in Iceland was higher than in an Asian population where the same inclusion criteria were applied. The clinical picture diverges partly from that in the Asian population but resembles that among other Caucasians. Fatigue and respiratory symptoms were predominant. The biphasic pattern ... |
author2 |
Faculty of Medicine Clinical Laboratory Services, Diagnostics and Blood Bank Internal Medicine and Emergency Services Landspitali - The National University Hospital of Iceland |
format |
Article in Journal/Newspaper |
author |
Haraldsdóttir, Sigríður Ólína Jonasson, Jon Gunnlaugur Jorundsdottir, Kristin Bara Hannesson, Haraldur Jon Gislason, Thorarinn Gudbjornsson, Bjorn |
author_facet |
Haraldsdóttir, Sigríður Ólína Jonasson, Jon Gunnlaugur Jorundsdottir, Kristin Bara Hannesson, Haraldur Jon Gislason, Thorarinn Gudbjornsson, Bjorn |
author_sort |
Haraldsdóttir, Sigríður Ólína |
title |
Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure |
title_short |
Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure |
title_full |
Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure |
title_fullStr |
Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure |
title_full_unstemmed |
Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure |
title_sort |
sarcoidosis in iceland : a nationwide study of epidemiology, clinical picture and environmental exposure |
publishDate |
2021 |
url |
https://hdl.handle.net/20.500.11815/3136 https://doi.org/10.1183/23120541.00550-2021 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
ERJ Open Research; 7(4) Haraldsdóttir , S Ó , Jonasson , J G , Jorundsdottir , K B , Hannesson , H J , Gislason , T & Gudbjornsson , B 2021 , ' Sarcoidosis in Iceland : A nationwide study of epidemiology, clinical picture and environmental exposure ' , ERJ Open Research , vol. 7 , no. 4 , 00550-2021 . https://doi.org/10.1183/23120541.00550-2021 2312-0541 48221662 c2aa60ab-c77f-421a-b625-88f257d372f0 85123548991 https://hdl.handle.net/20.500.11815/3136 doi:10.1183/23120541.00550-2021 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/313610.1183/23120541.00550-2021 |
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ERJ Open Research |
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7 |
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00550-2021 |
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