Copeptin is associated with mortality in elderly people
© 2021 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. BACKGROUND: Elevated copeptin, a marker for vasopressin release, has been associated with impaired prognosis in...
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Online Access: | https://hdl.handle.net/20.500.11815/3071 https://doi.org/10.1111/eci.13516 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/3071 2023-11-12T04:19:38+01:00 Copeptin is associated with mortality in elderly people Smaradottir, Maria Isabel Andersen, Karl Gudnason, Vilmundur Näsman, Per Rydén, Lars Mellbin, Linda Garcia Faculty of Medicine 2021-07 116595 e13516 https://hdl.handle.net/20.500.11815/3071 https://doi.org/10.1111/eci.13516 en eng European Journal of Clinical Investigation; 51(7) http://www.scopus.com/inward/record.url?scp=85100905812&partnerID=8YFLogxK Smaradottir , M I , Andersen , K , Gudnason , V , Näsman , P , Rydén , L & Mellbin , L G 2021 , ' Copeptin is associated with mortality in elderly people ' , European Journal of Clinical Investigation , vol. 51 , no. 7 , e13516 , pp. e13516 . https://doi.org/10.1111/eci.13516 0014-2972 38445413 ee79e6ad-5d8f-459e-bcb1-db1f6258cb18 85100905812 33569762 https://hdl.handle.net/20.500.11815/3071 doi:10.1111/eci.13516 info:eu-repo/semantics/openAccess Hormónar Dánartíðni Amínósýrur Hjartadrep copeptin cortisol myocardial infarction NTproBNP unknown myocardial infarction vasopressin Heart Failure/epidemiology Recurrence Cardiovascular Diseases/mortality Prognosis Humans Mortality Proportional Hazards Models Male Hydrocortisone/blood Glycopeptides/blood Myocardial Infarction/blood Aged 80 and over Female Stroke/epidemiology Peptide Fragments/blood Myocardial Revascularization/statistics & numerical data Natriuretic Peptide Brain/blood Biochemistry Clinical Biochemistry /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2021 ftopinvisindi https://doi.org/20.500.11815/307110.1111/eci.13516 2023-11-01T23:55:18Z © 2021 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. BACKGROUND: Elevated copeptin, a marker for vasopressin release, has been associated with impaired prognosis in acute myocardial infarction (MI). The aim was to investigate whether this association extends beyond the acute phase and whether it is related to markers of stress (cortisol) and heart failure (NTproBNP). METHODS: Copeptin, cortisol and NTproBNP were measured in 926 participants (age: 76.0; male: 48.5%) in the ICELAND MI study whereof 246 had a previous MI (91 recognizable (RMI) and 155 previously unrecognizable (UMI) detected by cardiac magnetic resonance imaging). The primary endpoint was cardiovascular events (CVEs), and secondary endpoints were total mortality, heart failure and MI (median follow-up was 9.1 years). The relation between copeptin and prognosis was assessed with the Cox proportional hazard regression (unadjusted, adjusted for cortisol and NTproBNP, respectively, and a multiple model: copeptin, cortisol, NTproBNP, age, sex, serum creatinine, heart failure). RESULTS: Copeptin was higher in participants with MI (8.9 vs. 6.4 pmol/L; P < .01), with no difference between RMI vs. UMI. Increased copeptin correlated with evening cortisol (r = .11; P < .01) and NTproBNP (r = .07; P = .04). Copeptin was associated with CVE and total mortality after adjusting for cortisol and NTproBNP separately, and remained significantly associated with total mortality in the multiple model. CONCLUSIONS: Copeptin was higher in subjects with previous MI regardless whether previously recognized or not. Copeptin correlated weakly with cortisol and NTproBNP, and was independently associated with total mortality. This indicates that the prognostic implications of copeptin are not only mediated by heart failure or stress, supporting the assumption that copeptin is a marker of general vulnerability. Peer reviewed Article in Journal/Newspaper Iceland Opin vísindi (Iceland) European Journal of Clinical Investigation 51 7 |
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Opin vísindi (Iceland) |
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English |
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Hormónar Dánartíðni Amínósýrur Hjartadrep copeptin cortisol myocardial infarction NTproBNP unknown myocardial infarction vasopressin Heart Failure/epidemiology Recurrence Cardiovascular Diseases/mortality Prognosis Humans Mortality Proportional Hazards Models Male Hydrocortisone/blood Glycopeptides/blood Myocardial Infarction/blood Aged 80 and over Female Stroke/epidemiology Peptide Fragments/blood Myocardial Revascularization/statistics & numerical data Natriuretic Peptide Brain/blood Biochemistry Clinical Biochemistry |
spellingShingle |
Hormónar Dánartíðni Amínósýrur Hjartadrep copeptin cortisol myocardial infarction NTproBNP unknown myocardial infarction vasopressin Heart Failure/epidemiology Recurrence Cardiovascular Diseases/mortality Prognosis Humans Mortality Proportional Hazards Models Male Hydrocortisone/blood Glycopeptides/blood Myocardial Infarction/blood Aged 80 and over Female Stroke/epidemiology Peptide Fragments/blood Myocardial Revascularization/statistics & numerical data Natriuretic Peptide Brain/blood Biochemistry Clinical Biochemistry Smaradottir, Maria Isabel Andersen, Karl Gudnason, Vilmundur Näsman, Per Rydén, Lars Mellbin, Linda Garcia Copeptin is associated with mortality in elderly people |
topic_facet |
Hormónar Dánartíðni Amínósýrur Hjartadrep copeptin cortisol myocardial infarction NTproBNP unknown myocardial infarction vasopressin Heart Failure/epidemiology Recurrence Cardiovascular Diseases/mortality Prognosis Humans Mortality Proportional Hazards Models Male Hydrocortisone/blood Glycopeptides/blood Myocardial Infarction/blood Aged 80 and over Female Stroke/epidemiology Peptide Fragments/blood Myocardial Revascularization/statistics & numerical data Natriuretic Peptide Brain/blood Biochemistry Clinical Biochemistry |
description |
© 2021 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. BACKGROUND: Elevated copeptin, a marker for vasopressin release, has been associated with impaired prognosis in acute myocardial infarction (MI). The aim was to investigate whether this association extends beyond the acute phase and whether it is related to markers of stress (cortisol) and heart failure (NTproBNP). METHODS: Copeptin, cortisol and NTproBNP were measured in 926 participants (age: 76.0; male: 48.5%) in the ICELAND MI study whereof 246 had a previous MI (91 recognizable (RMI) and 155 previously unrecognizable (UMI) detected by cardiac magnetic resonance imaging). The primary endpoint was cardiovascular events (CVEs), and secondary endpoints were total mortality, heart failure and MI (median follow-up was 9.1 years). The relation between copeptin and prognosis was assessed with the Cox proportional hazard regression (unadjusted, adjusted for cortisol and NTproBNP, respectively, and a multiple model: copeptin, cortisol, NTproBNP, age, sex, serum creatinine, heart failure). RESULTS: Copeptin was higher in participants with MI (8.9 vs. 6.4 pmol/L; P < .01), with no difference between RMI vs. UMI. Increased copeptin correlated with evening cortisol (r = .11; P < .01) and NTproBNP (r = .07; P = .04). Copeptin was associated with CVE and total mortality after adjusting for cortisol and NTproBNP separately, and remained significantly associated with total mortality in the multiple model. CONCLUSIONS: Copeptin was higher in subjects with previous MI regardless whether previously recognized or not. Copeptin correlated weakly with cortisol and NTproBNP, and was independently associated with total mortality. This indicates that the prognostic implications of copeptin are not only mediated by heart failure or stress, supporting the assumption that copeptin is a marker of general vulnerability. Peer reviewed |
author2 |
Faculty of Medicine |
format |
Article in Journal/Newspaper |
author |
Smaradottir, Maria Isabel Andersen, Karl Gudnason, Vilmundur Näsman, Per Rydén, Lars Mellbin, Linda Garcia |
author_facet |
Smaradottir, Maria Isabel Andersen, Karl Gudnason, Vilmundur Näsman, Per Rydén, Lars Mellbin, Linda Garcia |
author_sort |
Smaradottir, Maria Isabel |
title |
Copeptin is associated with mortality in elderly people |
title_short |
Copeptin is associated with mortality in elderly people |
title_full |
Copeptin is associated with mortality in elderly people |
title_fullStr |
Copeptin is associated with mortality in elderly people |
title_full_unstemmed |
Copeptin is associated with mortality in elderly people |
title_sort |
copeptin is associated with mortality in elderly people |
publishDate |
2021 |
url |
https://hdl.handle.net/20.500.11815/3071 https://doi.org/10.1111/eci.13516 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
European Journal of Clinical Investigation; 51(7) http://www.scopus.com/inward/record.url?scp=85100905812&partnerID=8YFLogxK Smaradottir , M I , Andersen , K , Gudnason , V , Näsman , P , Rydén , L & Mellbin , L G 2021 , ' Copeptin is associated with mortality in elderly people ' , European Journal of Clinical Investigation , vol. 51 , no. 7 , e13516 , pp. e13516 . https://doi.org/10.1111/eci.13516 0014-2972 38445413 ee79e6ad-5d8f-459e-bcb1-db1f6258cb18 85100905812 33569762 https://hdl.handle.net/20.500.11815/3071 doi:10.1111/eci.13516 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/307110.1111/eci.13516 |
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European Journal of Clinical Investigation |
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51 |
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7 |
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