A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
Funding text 1 We thank all the study subjects for their valuable participation, the staff from all studies, and the participating physicians. Participants in the INTERVAL randomized controlled trial were recruited with the active collaboration of NHS Blood and Transplant England (www.nhsbt.nhs.uk),...
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/2956 2023-11-12T04:19:38+01:00 A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis DBDS Genomic Consortium Thorsteinsdottir, Unnur Faculty of Medicine Faculty of Industrial Engineering, Mechanical Engineering and Computer Science Clinical Laboratory Services, Diagnostics and Blood Bank Faculty of Physical Sciences Health Sciences 2021-02-03 2936244 156 https://hdl.handle.net/20.500.11815/2956 https://doi.org/10.1038/s42003-020-01575-z en eng Communications Biology; 4(1) http://www.scopus.com/inward/record.url?scp=85100560134&partnerID=8YFLogxK DBDS Genomic Consortium & Thorsteinsdottir , U 2021 , ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ' , Communications Biology , vol. 4 , no. 1 , 156 , pp. 156 . https://doi.org/10.1038/s42003-020-01575-z 2399-3642 36966159 9ce4e501-fab2-41c4-9516-418c8af5bafd 85100560134 33536631 000617687000002 unpaywall: 10.1038/s42003-020-01575-z https://hdl.handle.net/20.500.11815/2956 doi:10.1038/s42003-020-01575-z info:eu-repo/semantics/openAccess Járn (næringarefni) Járnskortur Erfðafræði Anemia Iron-Deficiency / genetics Iron overload / genetics Iron / blood Genome-Wide Association Study Iron-Deficiency/blood Risk Assessment Humans Risk Factors Homeostasis Genotype United Kingdom Transferrin/metabolism Genetic Loci Iceland Genetic Variation Phenotype Iron/blood Denmark Biomarkers/blood Iron Overload/blood Ferritins/blood Agricultural and Biological Sciences (all) Biochemistry Genetics and Molecular Biology (all) Medicine (miscellaneous) /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2021 ftopinvisindi https://doi.org/20.500.11815/295610.1038/s42003-020-01575-z 2023-11-01T23:55:18Z Funding text 1 We thank all the study subjects for their valuable participation, the staff from all studies, and the participating physicians. Participants in the INTERVAL randomized controlled trial were recruited with the active collaboration of NHS Blood and Transplant England (www.nhsbt.nhs.uk), which has supported fieldwork and other elements of the trial. DNA extraction and genotyping were co-funded by the National Institute for Health Research (NIHR), the NIHR BioResource (http://bioresource.nihr.ac.uk/) and the NIHR Cambridge Biomedical Research Centre (BRC) [*]. The academic coordinating centre for INTERVAL was supported by core funding from NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024), UK Medical Research Council (MR/L003120/1), British Heart Foundation (SP/09/002; RG/13/13/30194; RG/ 18/13/33946) and the NIHR Cambridge BRC [*]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. A complete list of the investigators and contributors to the INTERVAL trial is provided in reference87. The academic coordinating centre would like to thank blood donor centre staff and blood donors for participating in the INTERVAL trial. Professor John Danesh holds a British Heart Foundation Professorship and a National Institute for Health Research Senior Investigator Award. Steven Bell and Dragana Vuckovic were funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). Stephen Kaptoge is funded by a BHF Program Grant (RG/18/13/33946). Will Astle, Joanna Howson, and Tao Jiang are funded by the NIHR Cambridge BRC. Angela M. Wood and Elias Allara are supported by the EC-Innovative Medicines Initiative (BigData@Heart). Praveen Surendran is supported by a Rutherford Fund Fellowship from the Medical Research Council grant MR/S003746/1. This work was supported by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Communications Biology 4 1 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Járn (næringarefni) Járnskortur Erfðafræði Anemia Iron-Deficiency / genetics Iron overload / genetics Iron / blood Genome-Wide Association Study Iron-Deficiency/blood Risk Assessment Humans Risk Factors Homeostasis Genotype United Kingdom Transferrin/metabolism Genetic Loci Iceland Genetic Variation Phenotype Iron/blood Denmark Biomarkers/blood Iron Overload/blood Ferritins/blood Agricultural and Biological Sciences (all) Biochemistry Genetics and Molecular Biology (all) Medicine (miscellaneous) |
spellingShingle |
Járn (næringarefni) Járnskortur Erfðafræði Anemia Iron-Deficiency / genetics Iron overload / genetics Iron / blood Genome-Wide Association Study Iron-Deficiency/blood Risk Assessment Humans Risk Factors Homeostasis Genotype United Kingdom Transferrin/metabolism Genetic Loci Iceland Genetic Variation Phenotype Iron/blood Denmark Biomarkers/blood Iron Overload/blood Ferritins/blood Agricultural and Biological Sciences (all) Biochemistry Genetics and Molecular Biology (all) Medicine (miscellaneous) DBDS Genomic Consortium Thorsteinsdottir, Unnur A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
topic_facet |
Járn (næringarefni) Járnskortur Erfðafræði Anemia Iron-Deficiency / genetics Iron overload / genetics Iron / blood Genome-Wide Association Study Iron-Deficiency/blood Risk Assessment Humans Risk Factors Homeostasis Genotype United Kingdom Transferrin/metabolism Genetic Loci Iceland Genetic Variation Phenotype Iron/blood Denmark Biomarkers/blood Iron Overload/blood Ferritins/blood Agricultural and Biological Sciences (all) Biochemistry Genetics and Molecular Biology (all) Medicine (miscellaneous) |
description |
Funding text 1 We thank all the study subjects for their valuable participation, the staff from all studies, and the participating physicians. Participants in the INTERVAL randomized controlled trial were recruited with the active collaboration of NHS Blood and Transplant England (www.nhsbt.nhs.uk), which has supported fieldwork and other elements of the trial. DNA extraction and genotyping were co-funded by the National Institute for Health Research (NIHR), the NIHR BioResource (http://bioresource.nihr.ac.uk/) and the NIHR Cambridge Biomedical Research Centre (BRC) [*]. The academic coordinating centre for INTERVAL was supported by core funding from NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024), UK Medical Research Council (MR/L003120/1), British Heart Foundation (SP/09/002; RG/13/13/30194; RG/ 18/13/33946) and the NIHR Cambridge BRC [*]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. A complete list of the investigators and contributors to the INTERVAL trial is provided in reference87. The academic coordinating centre would like to thank blood donor centre staff and blood donors for participating in the INTERVAL trial. Professor John Danesh holds a British Heart Foundation Professorship and a National Institute for Health Research Senior Investigator Award. Steven Bell and Dragana Vuckovic were funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). Stephen Kaptoge is funded by a BHF Program Grant (RG/18/13/33946). Will Astle, Joanna Howson, and Tao Jiang are funded by the NIHR Cambridge BRC. Angela M. Wood and Elias Allara are supported by the EC-Innovative Medicines Initiative (BigData@Heart). Praveen Surendran is supported by a Rutherford Fund Fellowship from the Medical Research Council grant MR/S003746/1. This work was supported by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and ... |
author2 |
Faculty of Medicine Faculty of Industrial Engineering, Mechanical Engineering and Computer Science Clinical Laboratory Services, Diagnostics and Blood Bank Faculty of Physical Sciences Health Sciences |
format |
Article in Journal/Newspaper |
author |
DBDS Genomic Consortium Thorsteinsdottir, Unnur |
author_facet |
DBDS Genomic Consortium Thorsteinsdottir, Unnur |
author_sort |
DBDS Genomic Consortium |
title |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_short |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_full |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_fullStr |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_full_unstemmed |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_sort |
genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
publishDate |
2021 |
url |
https://hdl.handle.net/20.500.11815/2956 https://doi.org/10.1038/s42003-020-01575-z |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Communications Biology; 4(1) http://www.scopus.com/inward/record.url?scp=85100560134&partnerID=8YFLogxK DBDS Genomic Consortium & Thorsteinsdottir , U 2021 , ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ' , Communications Biology , vol. 4 , no. 1 , 156 , pp. 156 . https://doi.org/10.1038/s42003-020-01575-z 2399-3642 36966159 9ce4e501-fab2-41c4-9516-418c8af5bafd 85100560134 33536631 000617687000002 unpaywall: 10.1038/s42003-020-01575-z https://hdl.handle.net/20.500.11815/2956 doi:10.1038/s42003-020-01575-z |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/295610.1038/s42003-020-01575-z |
container_title |
Communications Biology |
container_volume |
4 |
container_issue |
1 |
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1782336005800460288 |