A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

• Published in: Communications Biology
• Main Authors: DBDS Genomic Consortium, Thorsteinsdottir, Unnur
• Other Authors: Faculty of Medicine, Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, Clinical Laboratory Services, Diagnostics and Blood Bank, Faculty of Physical Sciences, Health Sciences
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2021
• Subjects: Járn (næringarefni); Járnskortur; Erfðafræði; Anemia; Iron-Deficiency / genetics; Iron overload / genetics; Iron / blood; Genome-Wide Association Study; Iron-Deficiency/blood; Risk Assessment; Humans; Risk Factors; Homeostasis; Genotype; United Kingdom; Transferrin/metabolism; Genetic Loci; Iceland; Genetic Variation; Phenotype; Iron/blood; Denmark; Biomarkers/blood; Iron Overload/blood; Ferritins/blood; Agricultural and Biological Sciences (all); Biochemistry; Genetics and Molecular Biology (all); Medicine (miscellaneous)
• Online Access: https://hdl.handle.net/20.500.11815/2956; https://doi.org/10.1038/s42003-020-01575-z

Funding text 1 We thank all the study subjects for their valuable participation, the staff from all studies, and the participating physicians. Participants in the INTERVAL randomized controlled trial were recruited with the active collaboration of NHS Blood and Transplant England (www.nhsbt.nhs.uk), which has supported fieldwork and other elements of the trial. DNA extraction and genotyping were co-funded by the National Institute for Health Research (NIHR), the NIHR BioResource (http://bioresource.nihr.ac.uk/) and the NIHR Cambridge Biomedical Research Centre (BRC) [*]. The academic coordinating centre for INTERVAL was supported by core funding from NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024), UK Medical Research Council (MR/L003120/1), British Heart Foundation (SP/09/002; RG/13/13/30194; RG/ 18/13/33946) and the NIHR Cambridge BRC [*]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. A complete list of the investigators and contributors to the INTERVAL trial is provided in reference87. The academic coordinating centre would like to thank blood donor centre staff and blood donors for participating in the INTERVAL trial. Professor John Danesh holds a British Heart Foundation Professorship and a National Institute for Health Research Senior Investigator Award. Steven Bell and Dragana Vuckovic were funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). Stephen Kaptoge is funded by a BHF Program Grant (RG/18/13/33946). Will Astle, Joanna Howson, and Tao Jiang are funded by the NIHR Cambridge BRC. Angela M. Wood and Elias Allara are supported by the EC-Innovative Medicines Initiative (BigData@Heart). Praveen Surendran is supported by a Rutherford Fund Fellowship from the Medical Research Council grant MR/S003746/1. This work was supported by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and ...