Breytingar í lungnavef á tölvusneiðmyndum sjúklinga með kórónuveirusjúkdóm 2019 (COVID-19)

• Published in: Læknablaðið
• Main Authors: Halldórsson, Arnljótur Björn, Axelsson, Gísli Þór, Jónsson, Helgi, Ísaksson, Jóhann Davíð, Harðardóttir, Hrönn, Guðmundsson, Gunnar, Hansdóttir, Sif
• Other Authors: Læknadeild, Lyflækninga- og bráðaþjónusta, Þverfræðilegt framhaldsnám, Landspítali
• Format: Article in Journal/Newspaper
• Language: Icelandic
• Published: 2021
• Subjects: COVID-19; Sneiðmyndatökur; Lungnabólga; (CT) scan; Computed Tomography; pneumonia; Adult; Age Factors; Aged; COVID-19/diagnostic imaging; Databases; Factual; Female; Hospitalization; Host-Pathogen Interactions; Humans; Iceland; Lung/diagnostic imaging; Male; Middle Aged; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; SARS-CoV-2/pathogenicity; Severity of Illness Index; Sex Factors; Tomography; X-Ray Computed; Læknisfræði (allt)
• Online Access: https://hdl.handle.net/20.500.11815/2911; https://doi.org/10.17992/lbl.2021.10.655

Introduction Infections due to COVID-19 can lead to life threatening pneumonia. Accompanying severe disease are more prominent pulmonary changes on Computed Tomography (CT) scan of the chest. The goal of this study was to describe pulmonary CT changes during acute COVID-19 and at follow up and whether the extent of changes correlate with severity of illness, demographics or other risk factors. Materials and methods Included in this study are all individuals that had confirmed COVID-19 and came for a follow up CT of the chest at Landspitali from May to September 2020. Information regarding medical history was obtained retrospectively from medical charts. All CT scans were reviewed using an international staging system to evaluate the extent of lung changes. Results Eighty-five patients with a mean age of 59 years were included in the study. Sixty patients (71%) were hospitalized during the acute phase and 18 (21%) were admitted to the ICU. During the acute phase more pronounced lung involvement was seen in males and patients admitted to the ICU. At follow-up females had less lung involvement but there was a significant relationship between a higher CT score and age, ICU admissions and days in the ICU. Full recovery was seen at follow-up CT in 31% of patients (median 68,5 days between acute and follow-up imaging). Conclusion Patients with severe COVID-19 have more pronounced lung involvement on CT than patients with milder disease during the acute phase and follow-up. Older patients and males are at greater risk of acute and persistent COVID-19 related lung changes. Peer reviewed