Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants
The authors wish to thank the University Hospital Landspitali in Reykjavik for its infrastructural support. Publisher Copyright: © 2021, The Author(s). Although previous studies have highlighted the association between physical activity and lower extremity function (LEF) in elderly individuals, the...
Published in: | Scientific Reports |
---|---|
Main Authors: | , , , , , , |
Other Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2021
|
Subjects: | |
Online Access: | https://hdl.handle.net/20.500.11815/2894 https://doi.org/10.1038/s41598-021-99699-7 |
id |
ftopinvisindi:oai:opinvisindi.is:20.500.11815/2894 |
---|---|
record_format |
openpolar |
spelling |
ftopinvisindi:oai:opinvisindi.is:20.500.11815/2894 2023-05-15T18:06:57+02:00 Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurðsson, Sigurður Lose, Sarah R. Guðnason, Vilmundur G. Carraro, Ugo Gargiulo, Paolo Faculty of Medicine Department of Engineering Other departments 2021-10-11 20173 https://hdl.handle.net/20.500.11815/2894 https://doi.org/10.1038/s41598-021-99699-7 en eng Scientific Reports; 11(1) http://www.scopus.com/inward/record.url?scp=85116835777&partnerID=8YFLogxK Edmunds , K J , Okonkwo , O C , Sigurðsson , S , Lose , S R , Guðnason , V G , Carraro , U & Gargiulo , P 2021 , ' Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants ' , Scientific Reports , vol. 11 , no. 1 , 20173 , pp. 20173 . https://doi.org/10.1038/s41598-021-99699-7 2045-2322 PURE: 41761002 PURE UUID: 391d5715-eae4-4b13-afcf-97e92a7cb597 Scopus: 85116835777 WOS: 000706395800074 https://hdl.handle.net/20.500.11815/2894 34635746 https://doi.org/10.1038/s41598-021-99699-7 info:eu-repo/semantics/openAccess Aldraðir Líkamsrækt Stoðkerfi (líffærafræði) Exercise Skeletal muscle self report walking speed Multidisciplinary /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2021 ftopinvisindi https://doi.org/20.500.11815/2894 https://doi.org/10.1038/s41598-021-99699-7 2022-11-18T06:52:16Z The authors wish to thank the University Hospital Landspitali in Reykjavik for its infrastructural support. Publisher Copyright: © 2021, The Author(s). Although previous studies have highlighted the association between physical activity and lower extremity function (LEF) in elderly individuals, the mechanisms underlying this relationship remain debated. Our recent work has recognized the utility of nonlinear trimodal regression analysis (NTRA) parameters in characterizing changes in soft tissue radiodensity as a quantitative construct for sarcopenia in the longitudinal, population-based cohort of the AGES-Reykjavík study. For the present work, we assembled a series of prospective multivariate regression models to interrogate whether NTRA parameters mediate the 5-year longitudinal relationship between physical activity and LEF in AGES-Reykjavík participants. Healthy elderly volunteers from the AGES-Reykjavík cohort underwent mid-thigh X-ray CT scans along with a four-part battery of LEF tasks: normal gait speed, fastest-comfortable gait speed, isometric leg strength, and timed up-and-go. These data were recorded at two study timepoints which were separated by approximately 5 years: AGES-I (n = 3157) and AGES-II (n = 3098). Participants in AGES-I were likewise administered a survey to approximate their weekly frequency of engaging in moderate-to-vigorous physical activity (PAAGES-I). Using a multivariate mediation analysis framework, linear regression models were assembled to test whether NTRA parameters mediated the longitudinal relationship between PAAGES-I and LEFAGES-II; all models were covariate-adjusted for age, sex, BMI, and baseline LEF, and results were corrected for multiple statistical comparisons. Our first series of models confirmed that all four LEF tasks were significantly related to PAAGES-I; next, modelling the relationship between PAAGES-I and NTRAAGES-II identified muscle amplitude (Nm) and location (μm) as potential mediators of LEF to test. Finally, adding these two parameters into our ... Article in Journal/Newspaper Reykjavík Reykjavík Opin vísindi (Iceland) Reykjavík Scientific Reports 11 1 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Aldraðir Líkamsrækt Stoðkerfi (líffærafræði) Exercise Skeletal muscle self report walking speed Multidisciplinary |
spellingShingle |
Aldraðir Líkamsrækt Stoðkerfi (líffærafræði) Exercise Skeletal muscle self report walking speed Multidisciplinary Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurðsson, Sigurður Lose, Sarah R. Guðnason, Vilmundur G. Carraro, Ugo Gargiulo, Paolo Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
topic_facet |
Aldraðir Líkamsrækt Stoðkerfi (líffærafræði) Exercise Skeletal muscle self report walking speed Multidisciplinary |
description |
The authors wish to thank the University Hospital Landspitali in Reykjavik for its infrastructural support. Publisher Copyright: © 2021, The Author(s). Although previous studies have highlighted the association between physical activity and lower extremity function (LEF) in elderly individuals, the mechanisms underlying this relationship remain debated. Our recent work has recognized the utility of nonlinear trimodal regression analysis (NTRA) parameters in characterizing changes in soft tissue radiodensity as a quantitative construct for sarcopenia in the longitudinal, population-based cohort of the AGES-Reykjavík study. For the present work, we assembled a series of prospective multivariate regression models to interrogate whether NTRA parameters mediate the 5-year longitudinal relationship between physical activity and LEF in AGES-Reykjavík participants. Healthy elderly volunteers from the AGES-Reykjavík cohort underwent mid-thigh X-ray CT scans along with a four-part battery of LEF tasks: normal gait speed, fastest-comfortable gait speed, isometric leg strength, and timed up-and-go. These data were recorded at two study timepoints which were separated by approximately 5 years: AGES-I (n = 3157) and AGES-II (n = 3098). Participants in AGES-I were likewise administered a survey to approximate their weekly frequency of engaging in moderate-to-vigorous physical activity (PAAGES-I). Using a multivariate mediation analysis framework, linear regression models were assembled to test whether NTRA parameters mediated the longitudinal relationship between PAAGES-I and LEFAGES-II; all models were covariate-adjusted for age, sex, BMI, and baseline LEF, and results were corrected for multiple statistical comparisons. Our first series of models confirmed that all four LEF tasks were significantly related to PAAGES-I; next, modelling the relationship between PAAGES-I and NTRAAGES-II identified muscle amplitude (Nm) and location (μm) as potential mediators of LEF to test. Finally, adding these two parameters into our ... |
author2 |
Faculty of Medicine Department of Engineering Other departments |
format |
Article in Journal/Newspaper |
author |
Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurðsson, Sigurður Lose, Sarah R. Guðnason, Vilmundur G. Carraro, Ugo Gargiulo, Paolo |
author_facet |
Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurðsson, Sigurður Lose, Sarah R. Guðnason, Vilmundur G. Carraro, Ugo Gargiulo, Paolo |
author_sort |
Edmunds, Kyle J. |
title |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_short |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_full |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_fullStr |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_full_unstemmed |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_sort |
soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in ages-reykjavík participants |
publishDate |
2021 |
url |
https://hdl.handle.net/20.500.11815/2894 https://doi.org/10.1038/s41598-021-99699-7 |
geographic |
Reykjavík |
geographic_facet |
Reykjavík |
genre |
Reykjavík Reykjavík |
genre_facet |
Reykjavík Reykjavík |
op_relation |
Scientific Reports; 11(1) http://www.scopus.com/inward/record.url?scp=85116835777&partnerID=8YFLogxK Edmunds , K J , Okonkwo , O C , Sigurðsson , S , Lose , S R , Guðnason , V G , Carraro , U & Gargiulo , P 2021 , ' Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants ' , Scientific Reports , vol. 11 , no. 1 , 20173 , pp. 20173 . https://doi.org/10.1038/s41598-021-99699-7 2045-2322 PURE: 41761002 PURE UUID: 391d5715-eae4-4b13-afcf-97e92a7cb597 Scopus: 85116835777 WOS: 000706395800074 https://hdl.handle.net/20.500.11815/2894 34635746 https://doi.org/10.1038/s41598-021-99699-7 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/2894 https://doi.org/10.1038/s41598-021-99699-7 |
container_title |
Scientific Reports |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766178667275223040 |