Stability characterization, kinetics and mechanism of tacrolimus degradation in cyclodextrin solutions

• Published in: International Journal of Pharmaceutics
• Main Authors: Prajapati, Manisha, Eiríksson, Finnur Freyr, Loftsson, Thorsteinn
• Other Authors: Lyfjafræðideild (HÍ), Faculty of Pharmaceutical Sciences (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2020
• Subjects: Cyclodextrins; Tacrolimus; Stability; Solubility; Kinetics; Sýklódextrín; Lyfjaefnafræði; Ferreira; Iceland
• Online Access: https://hdl.handle.net/20.500.11815/2458; https://doi.org/10.1016/j.ijpharm.2020.119579

Tacrolimus is a macrolide lactone and potent immunosuppressant. It is highly lipophilic and has very limited aqueous solubility. Tacrolimus is highly susceptible to hydrolysis which results in very limited stability in aqueous solutions. Besides this, tacrolimus also undergoes dehydration and epimer...