Antipsychotic drug use in pregnancy: A multinational study from ten countries
Publisher's version (útgefin grein) Aim: To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods: Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Swede...
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/2345 2023-05-15T16:52:07+02:00 Antipsychotic drug use in pregnancy: A multinational study from ten countries Reutfors, Johan Cesta, Carolyn E. Cohen, Jacqueline M. Bateman, Brian T. Brauer, Ruth Einarsdóttir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit K. Li, Jiong Man, Kenneth K.C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland 2020-06 106-115 https://hdl.handle.net/20.500.11815/2345 https://doi.org/10.1016/j.schres.2020.03.048 en eng Elsevier BV Schizophrenia Research;220 https://www.sciencedirect.com/science/article/pii/S0920996420301584?via%3Dihub Reutfors, J., Cesta, C., Cohen, J., Bateman, B., Brauer, R., Einarsdóttir, K., . . . Schaffer, A. (2020). Antipsychotic drug use in pregnancy: A multinational study from ten countries. Schizophrenia Research, 220, 106-115. 0920-9964 https://hdl.handle.net/20.500.11815/2345 Schizophrenia Research doi:10.1016/j.schres.2020.03.048 info:eu-repo/semantics/openAccess Antipsychotics Drug utilization study Epidemiology Pharmacological treatment Pregnancy Geðlyf Meðganga info:eu-repo/semantics/article 2020 ftopinvisindi https://doi.org/20.500.11815/2345 https://doi.org/10.1016/j.schres.2020.03.048 2022-11-18T06:52:04Z Publisher's version (útgefin grein) Aim: To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods: Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Sweden (2006–2015), Germany (2006–2015), Australia (New South Wales, 2004–2012), Hong Kong (2001–2015), UK (2006–2016), and the US (Medicaid, 2000–2013, and IBM MarketScan, 2012–2015) were used. Using a uniformed approach, we estimated the prevalence of antipsychotic use as the proportion of pregnancies where a woman filled at least one antipsychotic prescription within three months before pregnancy until birth. For the Nordic countries, data were meta-analyzed to investigate maternal characteristics associated with the use of antipsychotics. Results: We included 8,394,343 pregnancies. Typical antipsychotic use was highest in the UK (4.4%) whereas atypical antipsychotic use was highest in the US Medicaid (1.5%). Atypical antipsychotic use increased over time in most populations, reaching 2% in Australia (2012) and US Medicaid (2013). In most countries, prochlorperazine was the most commonly used typical antipsychotic and quetiapine the most commonly used atypical antipsychotic. Use of antipsychotics decreased across the trimesters of pregnancy in all populations except Finland. Antipsychotic use was elevated among smokers and those with parity ≥4 in the Nordic countries. Conclusion: Antipsychotic use during pregnancy varied considerably between populations, partly explained by varying use of the typical antipsychotic prochlorperazine, which is often used for nausea and vomiting in early pregnancy. Increasing usage of atypical antipsychotics among pregnant women reflects the pattern that was previously reported for the general population. This study was funded in part by NordForsk as part of the Nordic Pregnancy Drug Safety Studies (NorPreSS) project (Project No: 83539 ), the Research Council of Norway as part of the ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Norway Schizophrenia Research 220 106 115 |
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Open Polar |
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Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Antipsychotics Drug utilization study Epidemiology Pharmacological treatment Pregnancy Geðlyf Meðganga |
spellingShingle |
Antipsychotics Drug utilization study Epidemiology Pharmacological treatment Pregnancy Geðlyf Meðganga Reutfors, Johan Cesta, Carolyn E. Cohen, Jacqueline M. Bateman, Brian T. Brauer, Ruth Einarsdóttir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit K. Li, Jiong Man, Kenneth K.C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella Antipsychotic drug use in pregnancy: A multinational study from ten countries |
topic_facet |
Antipsychotics Drug utilization study Epidemiology Pharmacological treatment Pregnancy Geðlyf Meðganga |
description |
Publisher's version (útgefin grein) Aim: To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods: Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Sweden (2006–2015), Germany (2006–2015), Australia (New South Wales, 2004–2012), Hong Kong (2001–2015), UK (2006–2016), and the US (Medicaid, 2000–2013, and IBM MarketScan, 2012–2015) were used. Using a uniformed approach, we estimated the prevalence of antipsychotic use as the proportion of pregnancies where a woman filled at least one antipsychotic prescription within three months before pregnancy until birth. For the Nordic countries, data were meta-analyzed to investigate maternal characteristics associated with the use of antipsychotics. Results: We included 8,394,343 pregnancies. Typical antipsychotic use was highest in the UK (4.4%) whereas atypical antipsychotic use was highest in the US Medicaid (1.5%). Atypical antipsychotic use increased over time in most populations, reaching 2% in Australia (2012) and US Medicaid (2013). In most countries, prochlorperazine was the most commonly used typical antipsychotic and quetiapine the most commonly used atypical antipsychotic. Use of antipsychotics decreased across the trimesters of pregnancy in all populations except Finland. Antipsychotic use was elevated among smokers and those with parity ≥4 in the Nordic countries. Conclusion: Antipsychotic use during pregnancy varied considerably between populations, partly explained by varying use of the typical antipsychotic prochlorperazine, which is often used for nausea and vomiting in early pregnancy. Increasing usage of atypical antipsychotics among pregnant women reflects the pattern that was previously reported for the general population. This study was funded in part by NordForsk as part of the Nordic Pregnancy Drug Safety Studies (NorPreSS) project (Project No: 83539 ), the Research Council of Norway as part of the ... |
author2 |
Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland |
format |
Article in Journal/Newspaper |
author |
Reutfors, Johan Cesta, Carolyn E. Cohen, Jacqueline M. Bateman, Brian T. Brauer, Ruth Einarsdóttir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit K. Li, Jiong Man, Kenneth K.C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella |
author_facet |
Reutfors, Johan Cesta, Carolyn E. Cohen, Jacqueline M. Bateman, Brian T. Brauer, Ruth Einarsdóttir, Kristjana Engeland, Anders Furu, Kari Gissler, Mika Havard, Alys Hernandez-Diaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Leinonen, Maarit K. Li, Jiong Man, Kenneth K.C. Pazzagli, Laura Schaffer, Andrea Schink, Tania Wang, Zixuan Yu, Yongfu Zoega, Helga Bröms, Gabriella |
author_sort |
Reutfors, Johan |
title |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_short |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_full |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_fullStr |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_full_unstemmed |
Antipsychotic drug use in pregnancy: A multinational study from ten countries |
title_sort |
antipsychotic drug use in pregnancy: a multinational study from ten countries |
publisher |
Elsevier BV |
publishDate |
2020 |
url |
https://hdl.handle.net/20.500.11815/2345 https://doi.org/10.1016/j.schres.2020.03.048 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Schizophrenia Research;220 https://www.sciencedirect.com/science/article/pii/S0920996420301584?via%3Dihub Reutfors, J., Cesta, C., Cohen, J., Bateman, B., Brauer, R., Einarsdóttir, K., . . . Schaffer, A. (2020). Antipsychotic drug use in pregnancy: A multinational study from ten countries. Schizophrenia Research, 220, 106-115. 0920-9964 https://hdl.handle.net/20.500.11815/2345 Schizophrenia Research doi:10.1016/j.schres.2020.03.048 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/2345 https://doi.org/10.1016/j.schres.2020.03.048 |
container_title |
Schizophrenia Research |
container_volume |
220 |
container_start_page |
106 |
op_container_end_page |
115 |
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1766042262888775680 |