Repositioning of the global epicentre of non-optimal cholesterol

Publisher's version (útgefin grein) High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varyi...

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Published in:Nature
Main Authors: Aspelund, Thor, Gudnason, Vilmundur
Other Authors: Háskóli Íslands, University of Iceland
Format: Article in Journal/Newspaper
Language:English
Published: Springer Science and Business Media LLC 2020
Subjects:
HDL
Online Access:https://hdl.handle.net/20.500.11815/2323
https://doi.org/10.1038/s41586-020-2338-1
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spelling ftopinvisindi:oai:opinvisindi.is:20.500.11815/2323 2023-05-15T16:30:10+02:00 Repositioning of the global epicentre of non-optimal cholesterol Aspelund, Thor Gudnason, Vilmundur Háskóli Íslands University of Iceland 2020-06-03 73-77 https://hdl.handle.net/20.500.11815/2323 https://doi.org/10.1038/s41586-020-2338-1 en eng Springer Science and Business Media LLC Nature;582(7810) https://www.nature.com/articles/s41586-020-2338-1 NCD Risk Factor Collaboration (NCD-RisC)., Taddei, C., Zhou, B. et al. Repositioning of the global epicentre of non-optimal cholesterol. Nature 582, 73–77 (2020). https://doi.org/10.1038/s41586-020-2338-1 0028-0836 1476-4687 (eISSN) https://hdl.handle.net/20.500.11815/2323 Nature doi:10.1038/s41586-020-2338-1 info:eu-repo/semantics/openAccess Cholesterol Lipid-lowering medications HDL Cardiovascular diseases Risk factors Blóðrásarsjúkdómar Kólesteról info:eu-repo/semantics/article 2020 ftopinvisindi https://doi.org/20.500.11815/2323 https://doi.org/10.1038/s41586-020-2338-1 2022-11-18T06:52:04Z Publisher's version (útgefin grein) High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve ... Article in Journal/Newspaper Greenland Iceland Opin vísindi (Iceland) Greenland Norway Pacific Nature 582 7810 73 77
institution Open Polar
collection Opin vísindi (Iceland)
op_collection_id ftopinvisindi
language English
topic Cholesterol
Lipid-lowering medications
HDL
Cardiovascular diseases
Risk factors
Blóðrásarsjúkdómar
Kólesteról
spellingShingle Cholesterol
Lipid-lowering medications
HDL
Cardiovascular diseases
Risk factors
Blóðrásarsjúkdómar
Kólesteról
Aspelund, Thor
Gudnason, Vilmundur
Repositioning of the global epicentre of non-optimal cholesterol
topic_facet Cholesterol
Lipid-lowering medications
HDL
Cardiovascular diseases
Risk factors
Blóðrásarsjúkdómar
Kólesteról
description Publisher's version (útgefin grein) High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve ...
author2 Háskóli Íslands
University of Iceland
format Article in Journal/Newspaper
author Aspelund, Thor
Gudnason, Vilmundur
author_facet Aspelund, Thor
Gudnason, Vilmundur
author_sort Aspelund, Thor
title Repositioning of the global epicentre of non-optimal cholesterol
title_short Repositioning of the global epicentre of non-optimal cholesterol
title_full Repositioning of the global epicentre of non-optimal cholesterol
title_fullStr Repositioning of the global epicentre of non-optimal cholesterol
title_full_unstemmed Repositioning of the global epicentre of non-optimal cholesterol
title_sort repositioning of the global epicentre of non-optimal cholesterol
publisher Springer Science and Business Media LLC
publishDate 2020
url https://hdl.handle.net/20.500.11815/2323
https://doi.org/10.1038/s41586-020-2338-1
geographic Greenland
Norway
Pacific
geographic_facet Greenland
Norway
Pacific
genre Greenland
Iceland
genre_facet Greenland
Iceland
op_relation Nature;582(7810)
https://www.nature.com/articles/s41586-020-2338-1
NCD Risk Factor Collaboration (NCD-RisC)., Taddei, C., Zhou, B. et al. Repositioning of the global epicentre of non-optimal cholesterol. Nature 582, 73–77 (2020). https://doi.org/10.1038/s41586-020-2338-1
0028-0836
1476-4687 (eISSN)
https://hdl.handle.net/20.500.11815/2323
Nature
doi:10.1038/s41586-020-2338-1
op_rights info:eu-repo/semantics/openAccess
op_doi https://doi.org/20.500.11815/2323
https://doi.org/10.1038/s41586-020-2338-1
container_title Nature
container_volume 582
container_issue 7810
container_start_page 73
op_container_end_page 77
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