Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

• Published in: Molecular Cell
• Main Authors: Louphrasitthiphol, Pakavarin, Siddaway, Robert, Loffreda, Alessia, Pogenberg, Vivian, Friedrichsen, Hans, Schepsky, Alexander, Zeng, Zhiqiang, Lu, Min, Strub, Thomas, Freter, Rasmus, Lisle, Richard, Suer, Eda, Thomas, Benjamin, Schuster-Böckler, Benjamin, Filippakopoulos, Panagis, Middleton, Mark, Lu, Xin, Patton, E. Elizabeth, Davidson, Irwin, Lambert, Jean-Philippe, Wilmanns, Matthias, Steingrimsson, Eirikur, Mazza, Davide, Goding, Colin R.
• Other Authors: Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier BV 2020
• Subjects: Acetylation; bHLH-LZ; DNA-binding affinity; E-box; Melanocyte; Melanoma; MITF; Transcription factor; Sortuæxli; DNA-rannsóknir; Le Cancer; Iceland
• Online Access: https://hdl.handle.net/20.500.11815/2240; https://doi.org/10.1016/j.molcel.2020.05.025

Publisher's version (útgefin grein) It is widely assumed that decreasing transcription factor DNA-binding affinity reduces transcription initiation by diminishing occupancy of sequence-specific regulatory elements. However, in vivo transcription factors find their binding sites while confronted...