Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants

• Published in: PLOS ONE
• Main Authors: Vehmeijer, Wouter B., Magnusdottir, Vigdis, Eliasdottir, Thorunn, Hardarson, Sveinn Hakon, Schalij-Delfos, Nicoline E., Stefánsson, Einar
• Other Authors: Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2016
• Subjects: Augnlækningar; Sjónhimna; Ungbörn; Nes; Nes’; Iceland
• Online Access: https://hdl.handle.net/20.500.11815/1930; https://doi.org/10.1371/journal.pone.0148077

Publisher's version (útgefin grein) Dual wavelength retinal oximetry has been developed for adults, but is not available for infants. Retinal oximetry may provide insight into the pathophysiology of oxygen-mediated diseases like retinopathy of prematurity. More insight in the oxygen metabolism of the retina in infants may provide valuable clues for better understanding and subsequent prevention or treatment of the disease. The measurements of oxygen saturation are obtained with two fundus images simultaneously captured in two different wavelengths of light. The comparison in light absorption of oxygenated and deoxygenated hemoglobin can be used to estimate the oxygen saturation within the retinal vessels by means of a software algorithm. This study aims to make retinal oximetry available for neonates. The first step towards estimating retinal oxygen saturation is determining the optical density ratio. Therefore, the purpose of this study is to image healthy newborn infants with a scanning laser ophthalmoscope and determine the optical density ratio for retinal oximetry analysis. This study was supported by the ODAS foundation (http://www.odasstichting.nl/) (Den Hoorn, The Netherlands) to NES; The Icelandic Center for Research (Rannís), Award nr.:141425-052, to ES; The University of Iceland Research Fund, to SHH; The Landspítali-University Hospital Research Fund, Award nr.: A-2015-011, to SHH; and the Helga Jónsdóttir and Sigurliði Kristjánsson Memorial Fund, to ES. Peer reviewed