Serum lipids in adults with late age-related macular degeneration: a case-control study
Publisher's version (útgefin grein) Background: Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized. The objective was to investigate the relationship between serum lipids and AMD i...
Published in: | Lipids in Health and Disease |
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Springer Science and Business Media LLC
2019
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Online Access: | https://hdl.handle.net/20.500.11815/1860 https://doi.org/10.1186/s12944-018-0954-7 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/1860 2023-05-15T16:49:04+02:00 Serum lipids in adults with late age-related macular degeneration: a case-control study Semba, Richard Moaddel, Ruin Cotch, Mary Frances Jonasson, Fridbert Eiriksdottir, Gudny Harris, Tamara B. Launer, Lenore J. Sun, Kai Klein, Ronald Schaumberg, Debra Ann Jónsson, Pálmi V. Gudnason, Vilmundur Ferrucci, Luigi Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland 2019-01-08 7 https://hdl.handle.net/20.500.11815/1860 https://doi.org/10.1186/s12944-018-0954-7 en eng Springer Science and Business Media LLC Lipids in Health and Disease;18(1) https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0954-7 Semba, R.D., Moaddel, R., Cotch, M.F. et al. Serum lipids in adults with late age-related macular degeneration: a case-control study. Lipids in Health and Disease 18, 7 (2019). https://doi.org/10.1186/s12944-018-0954-7 1476-511X https://hdl.handle.net/20.500.11815/1860 Lipids in Health and Disease doi:10.1186/s12944-018-0954-7 info:eu-repo/semantics/openAccess Age-related macular degeneration Aging Geographic atrophy Lipids Mass spectrometry Neovascular AMD Öldrun Fituefni info:eu-repo/semantics/article 2019 ftopinvisindi https://doi.org/20.500.11815/1860 https://doi.org/10.1186/s12944-018-0954-7 2022-11-18T06:51:57Z Publisher's version (útgefin grein) Background: Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized. The objective was to investigate the relationship between serum lipids and AMD in older adults using a lipidomic approach. Methods: In a case-control study, 240 adults, aged ≥66 years, a third each having geographic atrophy, neovascular AMD, or no signs of AMD, were selected from a population-based sample of participants in the Age Gene/Environment Susceptibility-Reykjavik Study. The exposure was serum lipids and risk factors for AMD. The outcome was late AMD, assessed through fundus images taken through dilated pupils using a 45-degree digital camera and grading for neovascular AMD and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Results: Of 177 serum lipid species measured, there were no significant differences in serum lipids between controls and those with geographic atrophy or neovascular AMD, respectively. Adults with neovascular AMD had higher total serum lysophosphatidylcholine (LPC) (P = 0.004) and serum LPC 18:0 (P = 0.0002) compared to those with geographic atrophy. Conclusion: Late AMD was not characterized by alterations in systemic lipids compared with normal controls. These findings suggest that there may be differences in the LPC pathway between adults with neovascular AMD and geographic atrophy. This work was supported by National Institutes of Health grants R01 AG027012 and R01 EY017362, the Intramural Research Programs of the National Institute on Aging and the National Eye Institute (ZIAEY00401 and National Institutes of Health contract numbers N01-AG-1-2100 and HHSN271201200022C), the Iceland Heart Association, the Icelandic Parliament, and the University of Iceland Research Fund. The National Eye Institute was involved in the design and conduct of the study in regard to collection of fundus photographs. The funders had no role in ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Lipids in Health and Disease 18 1 |
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Open Polar |
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Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Age-related macular degeneration Aging Geographic atrophy Lipids Mass spectrometry Neovascular AMD Öldrun Fituefni |
spellingShingle |
Age-related macular degeneration Aging Geographic atrophy Lipids Mass spectrometry Neovascular AMD Öldrun Fituefni Semba, Richard Moaddel, Ruin Cotch, Mary Frances Jonasson, Fridbert Eiriksdottir, Gudny Harris, Tamara B. Launer, Lenore J. Sun, Kai Klein, Ronald Schaumberg, Debra Ann Jónsson, Pálmi V. Gudnason, Vilmundur Ferrucci, Luigi Serum lipids in adults with late age-related macular degeneration: a case-control study |
topic_facet |
Age-related macular degeneration Aging Geographic atrophy Lipids Mass spectrometry Neovascular AMD Öldrun Fituefni |
description |
Publisher's version (útgefin grein) Background: Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized. The objective was to investigate the relationship between serum lipids and AMD in older adults using a lipidomic approach. Methods: In a case-control study, 240 adults, aged ≥66 years, a third each having geographic atrophy, neovascular AMD, or no signs of AMD, were selected from a population-based sample of participants in the Age Gene/Environment Susceptibility-Reykjavik Study. The exposure was serum lipids and risk factors for AMD. The outcome was late AMD, assessed through fundus images taken through dilated pupils using a 45-degree digital camera and grading for neovascular AMD and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Results: Of 177 serum lipid species measured, there were no significant differences in serum lipids between controls and those with geographic atrophy or neovascular AMD, respectively. Adults with neovascular AMD had higher total serum lysophosphatidylcholine (LPC) (P = 0.004) and serum LPC 18:0 (P = 0.0002) compared to those with geographic atrophy. Conclusion: Late AMD was not characterized by alterations in systemic lipids compared with normal controls. These findings suggest that there may be differences in the LPC pathway between adults with neovascular AMD and geographic atrophy. This work was supported by National Institutes of Health grants R01 AG027012 and R01 EY017362, the Intramural Research Programs of the National Institute on Aging and the National Eye Institute (ZIAEY00401 and National Institutes of Health contract numbers N01-AG-1-2100 and HHSN271201200022C), the Iceland Heart Association, the Icelandic Parliament, and the University of Iceland Research Fund. The National Eye Institute was involved in the design and conduct of the study in regard to collection of fundus photographs. The funders had no role in ... |
author2 |
Læknadeild (HÍ) Faculty of Medicine (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland |
format |
Article in Journal/Newspaper |
author |
Semba, Richard Moaddel, Ruin Cotch, Mary Frances Jonasson, Fridbert Eiriksdottir, Gudny Harris, Tamara B. Launer, Lenore J. Sun, Kai Klein, Ronald Schaumberg, Debra Ann Jónsson, Pálmi V. Gudnason, Vilmundur Ferrucci, Luigi |
author_facet |
Semba, Richard Moaddel, Ruin Cotch, Mary Frances Jonasson, Fridbert Eiriksdottir, Gudny Harris, Tamara B. Launer, Lenore J. Sun, Kai Klein, Ronald Schaumberg, Debra Ann Jónsson, Pálmi V. Gudnason, Vilmundur Ferrucci, Luigi |
author_sort |
Semba, Richard |
title |
Serum lipids in adults with late age-related macular degeneration: a case-control study |
title_short |
Serum lipids in adults with late age-related macular degeneration: a case-control study |
title_full |
Serum lipids in adults with late age-related macular degeneration: a case-control study |
title_fullStr |
Serum lipids in adults with late age-related macular degeneration: a case-control study |
title_full_unstemmed |
Serum lipids in adults with late age-related macular degeneration: a case-control study |
title_sort |
serum lipids in adults with late age-related macular degeneration: a case-control study |
publisher |
Springer Science and Business Media LLC |
publishDate |
2019 |
url |
https://hdl.handle.net/20.500.11815/1860 https://doi.org/10.1186/s12944-018-0954-7 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Lipids in Health and Disease;18(1) https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0954-7 Semba, R.D., Moaddel, R., Cotch, M.F. et al. Serum lipids in adults with late age-related macular degeneration: a case-control study. Lipids in Health and Disease 18, 7 (2019). https://doi.org/10.1186/s12944-018-0954-7 1476-511X https://hdl.handle.net/20.500.11815/1860 Lipids in Health and Disease doi:10.1186/s12944-018-0954-7 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/1860 https://doi.org/10.1186/s12944-018-0954-7 |
container_title |
Lipids in Health and Disease |
container_volume |
18 |
container_issue |
1 |
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1766039130514391040 |