Antidiabetic medication use during pregnancy: an international utilization study
Publisher's version (útgefin grein). Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence and patterns of use of ADM in pregnancy from 2006 onward in seven different countries was assessed. R...
Published in: | BMJ Open Diabetes Research & Care |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/1585 2023-05-15T16:52:07+02:00 Antidiabetic medication use during pregnancy: an international utilization study Cesta, Carolyn E Cohen, Jacqueline M Pazzagli, Laura Bateman, Brian T Bröms, Gabriella Einarsdottir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-Diaz, Sonia Huybrechts, Krista F Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K Gulseth, Hanne L Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild Læknadeild (HÍ) Faculty of Medicine (UI) Miðstöð í lýðheilsuvísindum (HÍ) The Centre of Public Health Sciences (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland 2019-11-01 e000759 https://hdl.handle.net/20.500.11815/1585 https://doi.org/10.1136/bmjdrc-2019-000759 en eng BMJ BMJ Open Diabetes Research & Care;7(1) https://syndication.highwire.org/content/doi/10.1136/bmjdrc-2019-000759 Cesta CE, Cohen JM, Pazzagli L, et alAntidiabetic medication use during pregnancy: an international utilization studyBMJ Open Diabetes Research and Care 2019;7:e000759. doi:10.1136/bmjdrc-2019-000759 2052-4897 https://hdl.handle.net/20.500.11815/1585 BMJ Open Diabetes Research and Care doi:10.1136/bmjdrc-2019-000759 info:eu-repo/semantics/openAccess Drug utilization Gestational diabetes mellitus Insulin Oral antidiabetics Pharmacoepidemiology Population-based studies Pregestational diabetes Pregnancy Meðganga Sykursýki Lyfjagjöf info:eu-repo/semantics/article 2019 ftopinvisindi https://doi.org/20.500.11815/1585 https://doi.org/10.1136/bmjdrc-2019-000759 2022-11-18T06:51:52Z Publisher's version (útgefin grein). Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence and patterns of use of ADM in pregnancy from 2006 onward in seven different countries was assessed. Research design and methods Data sources included individually linked data from the nationwide health registers in Denmark (2006-2016), Finland (2006-2016), Iceland (2006-2012), Norway (2006-2015), Sweden (2006-2015), state-wide administrative and claims data for New South Wales, Australia (2006-2012) and two US insurance databases: Medicaid Analytic eXtract (MAX; 2006-2012, public) and IBM MarketScan (2012-2015, private). The prevalence of ADM use was calculated as the proportion of pregnancies with at least one filled prescription of an ADM in the 90 days before pregnancy or within the three trimesters of pregnancy. Results Prevalence of any ADM use in 5 279 231 pregnancies was 3% (n=147 999) and varied from under 2% (Denmark, Norway, and Sweden) to above 5% (Australia and US). Insulin was the most used ADM, and metformin was the most used oral hypoglycemic agent with increasing use over time in all countries. In 11.4%-62.5% of pregnancies with prepregnancy use, ADM (primarily metformin) was discontinued. When ADM treatment was initiated in late pregnancy for treatment of gestational diabetes mellitus, insulin was most often dispensed, except in the US, where glibenclamide was most often used. Conclusions Prevalence and patterns of use of ADM classes varied between countries and over time. While insulin remained the most common ADM used in pregnancy, metformin use increased significantly over the study period. g This study was funded by NordForsk as part of the Nordic Pregnancy Drug Safety Studies project (Project No: 83539) and the Research Council of Norway as part of the International Pregnancy Drug Safety Studies (InPreSS) (Project No: 273366) both awarded to KF at Norwegian Institute of Public Health (NIHP). ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Norway BMJ Open Diabetes Research & Care 7 1 e000759 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Drug utilization Gestational diabetes mellitus Insulin Oral antidiabetics Pharmacoepidemiology Population-based studies Pregestational diabetes Pregnancy Meðganga Sykursýki Lyfjagjöf |
spellingShingle |
Drug utilization Gestational diabetes mellitus Insulin Oral antidiabetics Pharmacoepidemiology Population-based studies Pregestational diabetes Pregnancy Meðganga Sykursýki Lyfjagjöf Cesta, Carolyn E Cohen, Jacqueline M Pazzagli, Laura Bateman, Brian T Bröms, Gabriella Einarsdottir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-Diaz, Sonia Huybrechts, Krista F Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K Gulseth, Hanne L Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild Antidiabetic medication use during pregnancy: an international utilization study |
topic_facet |
Drug utilization Gestational diabetes mellitus Insulin Oral antidiabetics Pharmacoepidemiology Population-based studies Pregestational diabetes Pregnancy Meðganga Sykursýki Lyfjagjöf |
description |
Publisher's version (útgefin grein). Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence and patterns of use of ADM in pregnancy from 2006 onward in seven different countries was assessed. Research design and methods Data sources included individually linked data from the nationwide health registers in Denmark (2006-2016), Finland (2006-2016), Iceland (2006-2012), Norway (2006-2015), Sweden (2006-2015), state-wide administrative and claims data for New South Wales, Australia (2006-2012) and two US insurance databases: Medicaid Analytic eXtract (MAX; 2006-2012, public) and IBM MarketScan (2012-2015, private). The prevalence of ADM use was calculated as the proportion of pregnancies with at least one filled prescription of an ADM in the 90 days before pregnancy or within the three trimesters of pregnancy. Results Prevalence of any ADM use in 5 279 231 pregnancies was 3% (n=147 999) and varied from under 2% (Denmark, Norway, and Sweden) to above 5% (Australia and US). Insulin was the most used ADM, and metformin was the most used oral hypoglycemic agent with increasing use over time in all countries. In 11.4%-62.5% of pregnancies with prepregnancy use, ADM (primarily metformin) was discontinued. When ADM treatment was initiated in late pregnancy for treatment of gestational diabetes mellitus, insulin was most often dispensed, except in the US, where glibenclamide was most often used. Conclusions Prevalence and patterns of use of ADM classes varied between countries and over time. While insulin remained the most common ADM used in pregnancy, metformin use increased significantly over the study period. g This study was funded by NordForsk as part of the Nordic Pregnancy Drug Safety Studies project (Project No: 83539) and the Research Council of Norway as part of the International Pregnancy Drug Safety Studies (InPreSS) (Project No: 273366) both awarded to KF at Norwegian Institute of Public Health (NIHP). ... |
author2 |
Læknadeild (HÍ) Faculty of Medicine (UI) Miðstöð í lýðheilsuvísindum (HÍ) The Centre of Public Health Sciences (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Háskóli Íslands University of Iceland |
format |
Article in Journal/Newspaper |
author |
Cesta, Carolyn E Cohen, Jacqueline M Pazzagli, Laura Bateman, Brian T Bröms, Gabriella Einarsdottir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-Diaz, Sonia Huybrechts, Krista F Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K Gulseth, Hanne L Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild |
author_facet |
Cesta, Carolyn E Cohen, Jacqueline M Pazzagli, Laura Bateman, Brian T Bröms, Gabriella Einarsdottir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-Diaz, Sonia Huybrechts, Krista F Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K Gulseth, Hanne L Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild |
author_sort |
Cesta, Carolyn E |
title |
Antidiabetic medication use during pregnancy: an international utilization study |
title_short |
Antidiabetic medication use during pregnancy: an international utilization study |
title_full |
Antidiabetic medication use during pregnancy: an international utilization study |
title_fullStr |
Antidiabetic medication use during pregnancy: an international utilization study |
title_full_unstemmed |
Antidiabetic medication use during pregnancy: an international utilization study |
title_sort |
antidiabetic medication use during pregnancy: an international utilization study |
publisher |
BMJ |
publishDate |
2019 |
url |
https://hdl.handle.net/20.500.11815/1585 https://doi.org/10.1136/bmjdrc-2019-000759 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
BMJ Open Diabetes Research & Care;7(1) https://syndication.highwire.org/content/doi/10.1136/bmjdrc-2019-000759 Cesta CE, Cohen JM, Pazzagli L, et alAntidiabetic medication use during pregnancy: an international utilization studyBMJ Open Diabetes Research and Care 2019;7:e000759. doi:10.1136/bmjdrc-2019-000759 2052-4897 https://hdl.handle.net/20.500.11815/1585 BMJ Open Diabetes Research and Care doi:10.1136/bmjdrc-2019-000759 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/1585 https://doi.org/10.1136/bmjdrc-2019-000759 |
container_title |
BMJ Open Diabetes Research & Care |
container_volume |
7 |
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1 |
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e000759 |
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1766042255055912960 |