Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland
Publisher's version (útgefin grein) Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from children i...
Published in: | Journal of Clinical Microbiology |
---|---|
Main Authors: | , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
American Society for Microbiology
2018
|
Subjects: | |
Online Access: | https://hdl.handle.net/20.500.11815/1221 https://doi.org/10.1128/JCM.01046-18 |
id |
ftopinvisindi:oai:opinvisindi.is:20.500.11815/1221 |
---|---|
record_format |
openpolar |
spelling |
ftopinvisindi:oai:opinvisindi.is:20.500.11815/1221 2023-05-15T16:49:04+02:00 Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland Quirk, Sigríður Júlía Haraldsson, Gunnsteinn Erlendsdóttir, Helga Hjálmarsdóttir, Martha Ásdís van Tonder, Andries J. Hrafnkelsson, Birgir Sigurdsson, Samuel Bentley, Stephen D. Haraldsson, Ásgeir Brueggemann, Angela B. Kristinsson, Karl G. Læknadeild (HÍ) Faculty of Medicine (UI) Lífvísindasetur (HÍ) Biomedical Center (UI) Raunvísindadeild (HÍ) Faculty of Physical Sciences (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Verkfræði- og náttúruvísindasvið (HÍ) School of Engineering and Natural Sciences (UI) Háskóli Íslands University of Iceland 2018-09-26 https://hdl.handle.net/20.500.11815/1221 https://doi.org/10.1128/JCM.01046-18 en eng American Society for Microbiology Journal of Clinical Microbiology;56(12) https://syndication.highwire.org/content/doi/10.1128/JCM.01046-18 Quirk, S. J., Haraldsson, G., Erlendsdóttir, H., Hjálmarsdóttir, M. Á., van Tonder, A. J., Hrafnkelsson, B., . . . Kristinsson, K. G. (2018). Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland. Journal of Clinical Microbiology, 56(12), e01046-01018. doi:10.1128/jcm.01046-18 0095-1137 1098-660X (eISSN) https://hdl.handle.net/20.500.11815/1221 Journal of Clinical Microbiology doi:10.1128/JCM.01046-18 info:eu-repo/semantics/openAccess Streptococcus pneumoniae Carriage Epidemiology Molecular epidemiology Otitis media Pneumococcus Vaccination Vaccine Pneumókokkar Eyrnabólga Bólusetningar Bóluefni Faraldsfræði info:eu-repo/semantics/article 2018 ftopinvisindi https://doi.org/20.500.11815/1221 https://doi.org/10.1128/JCM.01046-18 https://doi.org/10.1128/jcm.01046-18 2022-11-18T06:51:45Z Publisher's version (útgefin grein) Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from children in Iceland. Pneumococci were collected between 2009 and 2017 from the nasopharynges of healthy children attending 15 day care centers and from the middle ears (MEs) of children with acute otitis media from the greater Reykjavik capital area. Isolates were serotyped and tested for antimicrobial susceptibility. Whole-genome sequencing (WGS) was performed on alternate isolates from 2009 to 2014, and serotypes and multilocus sequence types (STs) were extracted from the WGS data. Two study periods were defined: 2009 to 2011 (PreVac) and 2012 to 2017 (PostVac). The overall nasopharyngeal carriage rate was similar between the two periods (67.3% PreVac and 61.5% PostVac, P = 0.090). Vaccine-type (VT) pneumococci decreased and nonvaccine-type (NVT) pneumococci (serotypes 6C, 15A, 15B/C, 21, 22F, 23A, 23B, 35F, and 35B) significantly increased in different age strata post-PCV introduction. The total number of pneumococci recovered from ME samples significantly decreased as did the proportion that were VTs, although NVT pneumococci (6C, 15B/C, 23A, and 23B) increased significantly. Most serotype 6C pneumococci were multidrug resistant (MDR). Serotype 19F was the predominant serotype associated with MEs, and it significantly decreased post-PCV introduction: these isolates were predominantly MDR and of the Taiwan19F-14 PMEN lineage. Overall, the nasopharyngeal carriage rate remained constant and the number of ME-associated pneumococci decreased significantly post-PCV introduction; however, there was a concomitant and statistically significant shift from VTs to NVTs in both collections of pneumococci. This was an investigator-initiated study funded by GlaxoSmithKline Biologicals SA. Grants were received from the Landspitali ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Journal of Clinical Microbiology 56 12 |
institution |
Open Polar |
collection |
Opin vísindi (Iceland) |
op_collection_id |
ftopinvisindi |
language |
English |
topic |
Streptococcus pneumoniae Carriage Epidemiology Molecular epidemiology Otitis media Pneumococcus Vaccination Vaccine Pneumókokkar Eyrnabólga Bólusetningar Bóluefni Faraldsfræði |
spellingShingle |
Streptococcus pneumoniae Carriage Epidemiology Molecular epidemiology Otitis media Pneumococcus Vaccination Vaccine Pneumókokkar Eyrnabólga Bólusetningar Bóluefni Faraldsfræði Quirk, Sigríður Júlía Haraldsson, Gunnsteinn Erlendsdóttir, Helga Hjálmarsdóttir, Martha Ásdís van Tonder, Andries J. Hrafnkelsson, Birgir Sigurdsson, Samuel Bentley, Stephen D. Haraldsson, Ásgeir Brueggemann, Angela B. Kristinsson, Karl G. Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland |
topic_facet |
Streptococcus pneumoniae Carriage Epidemiology Molecular epidemiology Otitis media Pneumococcus Vaccination Vaccine Pneumókokkar Eyrnabólga Bólusetningar Bóluefni Faraldsfræði |
description |
Publisher's version (útgefin grein) Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from children in Iceland. Pneumococci were collected between 2009 and 2017 from the nasopharynges of healthy children attending 15 day care centers and from the middle ears (MEs) of children with acute otitis media from the greater Reykjavik capital area. Isolates were serotyped and tested for antimicrobial susceptibility. Whole-genome sequencing (WGS) was performed on alternate isolates from 2009 to 2014, and serotypes and multilocus sequence types (STs) were extracted from the WGS data. Two study periods were defined: 2009 to 2011 (PreVac) and 2012 to 2017 (PostVac). The overall nasopharyngeal carriage rate was similar between the two periods (67.3% PreVac and 61.5% PostVac, P = 0.090). Vaccine-type (VT) pneumococci decreased and nonvaccine-type (NVT) pneumococci (serotypes 6C, 15A, 15B/C, 21, 22F, 23A, 23B, 35F, and 35B) significantly increased in different age strata post-PCV introduction. The total number of pneumococci recovered from ME samples significantly decreased as did the proportion that were VTs, although NVT pneumococci (6C, 15B/C, 23A, and 23B) increased significantly. Most serotype 6C pneumococci were multidrug resistant (MDR). Serotype 19F was the predominant serotype associated with MEs, and it significantly decreased post-PCV introduction: these isolates were predominantly MDR and of the Taiwan19F-14 PMEN lineage. Overall, the nasopharyngeal carriage rate remained constant and the number of ME-associated pneumococci decreased significantly post-PCV introduction; however, there was a concomitant and statistically significant shift from VTs to NVTs in both collections of pneumococci. This was an investigator-initiated study funded by GlaxoSmithKline Biologicals SA. Grants were received from the Landspitali ... |
author2 |
Læknadeild (HÍ) Faculty of Medicine (UI) Lífvísindasetur (HÍ) Biomedical Center (UI) Raunvísindadeild (HÍ) Faculty of Physical Sciences (UI) Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Verkfræði- og náttúruvísindasvið (HÍ) School of Engineering and Natural Sciences (UI) Háskóli Íslands University of Iceland |
format |
Article in Journal/Newspaper |
author |
Quirk, Sigríður Júlía Haraldsson, Gunnsteinn Erlendsdóttir, Helga Hjálmarsdóttir, Martha Ásdís van Tonder, Andries J. Hrafnkelsson, Birgir Sigurdsson, Samuel Bentley, Stephen D. Haraldsson, Ásgeir Brueggemann, Angela B. Kristinsson, Karl G. |
author_facet |
Quirk, Sigríður Júlía Haraldsson, Gunnsteinn Erlendsdóttir, Helga Hjálmarsdóttir, Martha Ásdís van Tonder, Andries J. Hrafnkelsson, Birgir Sigurdsson, Samuel Bentley, Stephen D. Haraldsson, Ásgeir Brueggemann, Angela B. Kristinsson, Karl G. |
author_sort |
Quirk, Sigríður Júlía |
title |
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland |
title_short |
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland |
title_full |
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland |
title_fullStr |
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland |
title_full_unstemmed |
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland |
title_sort |
effect of vaccination on pneumococci isolated from the nasopharynx of healthy children and the middle ear of children with otitis media in iceland |
publisher |
American Society for Microbiology |
publishDate |
2018 |
url |
https://hdl.handle.net/20.500.11815/1221 https://doi.org/10.1128/JCM.01046-18 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Journal of Clinical Microbiology;56(12) https://syndication.highwire.org/content/doi/10.1128/JCM.01046-18 Quirk, S. J., Haraldsson, G., Erlendsdóttir, H., Hjálmarsdóttir, M. Á., van Tonder, A. J., Hrafnkelsson, B., . . . Kristinsson, K. G. (2018). Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland. Journal of Clinical Microbiology, 56(12), e01046-01018. doi:10.1128/jcm.01046-18 0095-1137 1098-660X (eISSN) https://hdl.handle.net/20.500.11815/1221 Journal of Clinical Microbiology doi:10.1128/JCM.01046-18 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/1221 https://doi.org/10.1128/JCM.01046-18 https://doi.org/10.1128/jcm.01046-18 |
container_title |
Journal of Clinical Microbiology |
container_volume |
56 |
container_issue |
12 |
_version_ |
1766039127883513856 |