Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity
Rutin was enzymatically acylated with hexadecanedioic acid, in tert‐amyl alcohol, by an immobilized lipase from Candida antartica “Novozym 435”. The effect of different techniques of water removal, temperature, concentration of rutin and diacid/rutin molar ratio was investigated. The obtained result...
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2017
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ftopenresearchl:oai:biblioboard.com:fbb5d244-8c7f-4b42-b666-6f9283f70be6 2023-05-15T14:15:40+02:00 Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity Slimane, Manel 2017-01-01T00:00:00Z application/pdf https://openresearchlibrary.org/viewer/fbb5d244-8c7f-4b42-b666-6f9283f70be6 https://openresearchlibrary.org/ext/api/media/fbb5d244-8c7f-4b42-b666-6f9283f70be6/assets/external_content.pdf https://doi.org/10.5772/67621 English eng IntechOpen https://openresearchlibrary.org/viewer/fbb5d244-8c7f-4b42-b666-6f9283f70be6 https://openresearchlibrary.org/ext/api/media/fbb5d244-8c7f-4b42-b666-6f9283f70be6/assets/external_content.pdf ISBN:9789535134237 doi:10.5772/67621 https://creativecommons.org/licenses/by/4.0/legalcode CC-BY MODID-6d55e02e354:IntechOpen Science / Life Sciences / Biochemistry bisacsh:SCI007000 CHAPTER 2017 ftopenresearchl https://doi.org/10.5772/67621 2021-03-17T11:40:19Z Rutin was enzymatically acylated with hexadecanedioic acid, in tert‐amyl alcohol, by an immobilized lipase from Candida antartica “Novozym 435”. The effect of different techniques of water removal, temperature, concentration of rutin and diacid/rutin molar ratio was investigated. The obtained results indicated that drying the media by adding the molecular sieves in the outer loop of the reactor was the most efficient method leading to water content lower than 200 ppm. The highest performances (conversion yield and initial rate) were reached at 90°C, 131 mM of rutin, and 118 mM of acid. Depending on the water content and the diacid/rutin molar ratio, only rutin 4‴‐hexadecanedioate or both rutin 4‴‐hexadecanedioate and dirutin 4‴, 4‴‐hexadecanedioate were synthesized. Book Part antartic* Open Research Library |
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Open Polar |
collection |
Open Research Library |
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ftopenresearchl |
language |
English |
topic |
Science / Life Sciences / Biochemistry bisacsh:SCI007000 |
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Science / Life Sciences / Biochemistry bisacsh:SCI007000 Slimane, Manel Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
topic_facet |
Science / Life Sciences / Biochemistry bisacsh:SCI007000 |
description |
Rutin was enzymatically acylated with hexadecanedioic acid, in tert‐amyl alcohol, by an immobilized lipase from Candida antartica “Novozym 435”. The effect of different techniques of water removal, temperature, concentration of rutin and diacid/rutin molar ratio was investigated. The obtained results indicated that drying the media by adding the molecular sieves in the outer loop of the reactor was the most efficient method leading to water content lower than 200 ppm. The highest performances (conversion yield and initial rate) were reached at 90°C, 131 mM of rutin, and 118 mM of acid. Depending on the water content and the diacid/rutin molar ratio, only rutin 4‴‐hexadecanedioate or both rutin 4‴‐hexadecanedioate and dirutin 4‴, 4‴‐hexadecanedioate were synthesized. |
format |
Book Part |
author |
Slimane, Manel |
author_facet |
Slimane, Manel |
author_sort |
Slimane, Manel |
title |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_short |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_full |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_fullStr |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_full_unstemmed |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_sort |
biocatalysis of rutin hexadecanedioate derivatives: effect of operating conditions on acylation performance and selectivity |
publisher |
IntechOpen |
publishDate |
2017 |
url |
https://openresearchlibrary.org/viewer/fbb5d244-8c7f-4b42-b666-6f9283f70be6 https://openresearchlibrary.org/ext/api/media/fbb5d244-8c7f-4b42-b666-6f9283f70be6/assets/external_content.pdf https://doi.org/10.5772/67621 |
genre |
antartic* |
genre_facet |
antartic* |
op_source |
MODID-6d55e02e354:IntechOpen |
op_relation |
https://openresearchlibrary.org/viewer/fbb5d244-8c7f-4b42-b666-6f9283f70be6 https://openresearchlibrary.org/ext/api/media/fbb5d244-8c7f-4b42-b666-6f9283f70be6/assets/external_content.pdf ISBN:9789535134237 doi:10.5772/67621 |
op_rights |
https://creativecommons.org/licenses/by/4.0/legalcode |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.5772/67621 |
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1766287988414742528 |