Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections
Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth a...
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ftopenresearchl:oai:biblioboard.com:cc41310d-307c-4bd5-9604-21beb31ac6fd 2023-05-15T13:33:20+02:00 Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections Selan, Laura 2016-01-01T00:00:00Z application/pdf https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf https://doi.org/10.5772/62908 English eng IntechOpen https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf ISBN:9789535124351 doi:10.5772/62908 https://creativecommons.org/licenses/by/4.0/legalcode CC-BY MODID-6d55e02e354:IntechOpen Medical / Microbiology bisacsh:MED052000 CHAPTER 2016 ftopenresearchl https://doi.org/10.5772/62908 2021-03-17T11:28:51Z Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth and can be used to this aim. We describe an innovative diagnostic tool to early diagnose medical device infections sustained by Staphylococci; then we list new compounds that modulate bacterial phenotype and reduce virulence without affecting bacterial viability so as to avoid the emergence of genetic resistances. These compounds are all derived from natural sources: prokaryotes, plants, and human body. From prokaryotes we studied new compounds extracted from different environmental bacterial species, including Antarctic species growing in extreme environments. We describe also the anti-biofilm properties of extracts obtained from plants well known since centuries in folk medicine. The humoral immune response is the source of the last anti-biofilm compound: transferrin (Tf), a protein derived from human plasma involved in inflammation and natural immunity. All these compounds can be used as scaffolds for the design of new drugs active on the sessile form of pathogens prevalent in human biofilm infections. Book Part Antarc* Antarctic Open Research Library Antarctic |
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Open Research Library |
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language |
English |
topic |
Medical / Microbiology bisacsh:MED052000 |
spellingShingle |
Medical / Microbiology bisacsh:MED052000 Selan, Laura Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
topic_facet |
Medical / Microbiology bisacsh:MED052000 |
description |
Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth and can be used to this aim. We describe an innovative diagnostic tool to early diagnose medical device infections sustained by Staphylococci; then we list new compounds that modulate bacterial phenotype and reduce virulence without affecting bacterial viability so as to avoid the emergence of genetic resistances. These compounds are all derived from natural sources: prokaryotes, plants, and human body. From prokaryotes we studied new compounds extracted from different environmental bacterial species, including Antarctic species growing in extreme environments. We describe also the anti-biofilm properties of extracts obtained from plants well known since centuries in folk medicine. The humoral immune response is the source of the last anti-biofilm compound: transferrin (Tf), a protein derived from human plasma involved in inflammation and natural immunity. All these compounds can be used as scaffolds for the design of new drugs active on the sessile form of pathogens prevalent in human biofilm infections. |
format |
Book Part |
author |
Selan, Laura |
author_facet |
Selan, Laura |
author_sort |
Selan, Laura |
title |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_short |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_full |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_fullStr |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_full_unstemmed |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_sort |
compounds from natural sources for new diagnostics and drugs against biofilm infections |
publisher |
IntechOpen |
publishDate |
2016 |
url |
https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf https://doi.org/10.5772/62908 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
MODID-6d55e02e354:IntechOpen |
op_relation |
https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf ISBN:9789535124351 doi:10.5772/62908 |
op_rights |
https://creativecommons.org/licenses/by/4.0/legalcode |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.5772/62908 |
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1766041435468988416 |