Expanding the Coding Potential of Vertebrate Mitochondrial Genomes: Lesson Learned from the Atlantic Cod
Vertebrate mitochondrial genomes are highly conserved in structure, gene content, and function. Most sequenced mitochondrial genomes represent bony fishes, and that of the Atlantic cod (Gadus morhua) is the best characterized among the fishes. In addition to the well-characterized 37 canonical gene...
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| Format: | Book Part |
| Language: | English |
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IntechOpen
2018
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| Online Access: | https://openresearchlibrary.org/viewer/b837e3db-4665-4152-a052-f9975acd09f2 https://openresearchlibrary.org/ext/api/media/b837e3db-4665-4152-a052-f9975acd09f2/assets/external_content.pdf https://doi.org/10.5772/intechopen.75883 |
| Summary: | Vertebrate mitochondrial genomes are highly conserved in structure, gene content, and function. Most sequenced mitochondrial genomes represent bony fishes, and that of the Atlantic cod (Gadus morhua) is the best characterized among the fishes. In addition to the well-characterized 37 canonical gene products encoded by vertebrate mitochondrial genomes, new classes of gene products representing peptides and noncoding RNAs have been discovered. The Atlantic cod encodes at least two peptides (MOTS-c and humanin (HN)), two long noncoding RNAs (lncCR-L and lncCR-H), and a number of small RNAs. Here, we review recent research in the Atlantic cod focusing on putative mitochondrial-derived peptides, the mitochondrial transcriptome, and noncoding RNAs. |
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