Prion protein gene (PRNP) variation in German and Danish cervids
The structure of cellular prion proteins encoded by the prion protein gene (PRNP) impacts susceptibility to transmissible spongiform encephalopathies, including chronic wasting disease (CWD) in deer. The recent emergence of CWD in Northern European reindeer (Rangifer tarandus), moose (Alces alces al...
Published in: | Veterinary Research |
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Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Springer Science and Business Media LLC
2024
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Subjects: |
PRNP
> Chronic wasting disease
> Denmark
> Germany
> cervid
> deer
> fallow deer
> genotype
> polymorphism
> red deer
> roe deer
> sika deer
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Online Access: | https://doi.org/10.1186/s13567-024-01340-8 https://www.openagrar.de/receive/openagrar_mods_00098493 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00060751/SD2024258.pdf https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01340-8 |
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00098493 2024-09-15T17:36:12+00:00 Prion protein gene (PRNP) variation in German and Danish cervids Ernst, Sonja Piestrzyńska-Kajtoch, Agata Gethmann, Jörn Natonek-Wiśniewska, Małgorzata Sadeghi, Balal Polak, Miroslaw P. Keller, Markus Gavier-Widén, Dolores Moazami-Goudarzi, Katayoun Houston, Fiona Groschup, Martin H. Fast, Christine 2024-08-02 https://doi.org/10.1186/s13567-024-01340-8 https://www.openagrar.de/receive/openagrar_mods_00098493 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00060751/SD2024258.pdf https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01340-8 eng eng Springer Science and Business Media LLC Veterinary research -- Vet Res -- 1297-9716 -- 0928-4249 -- 2012391-7 -- 1146298-x -- https://veterinaryresearch.biomedcentral.com/ -- https://link.springer.com/journal/13567 -- http://www.bibliothek.uni-regensburg.de/ezeit/?2012391 -- https://www.ncbi.nlm.nih.gov/pmc/journals/892/ -- http://www.vetres-archive.org//pages/article.php https://doi.org/10.1186/s13567-024-01340-8 https://www.openagrar.de/receive/openagrar_mods_00098493 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00060751/SD2024258.pdf https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01340-8 https://creativecommons.org/licenses/by/4.0/ public info:eu-repo/semantics/openAccess article Text ddc:570 PRNP -- Chronic wasting disease -- Denmark -- Germany -- cervid -- deer -- fallow deer -- genotype -- polymorphism -- red deer -- roe deer -- sika deer article Text doc-type:article 2024 ftopenagrar https://doi.org/10.1186/s13567-024-01340-8 2024-08-05T23:36:43Z The structure of cellular prion proteins encoded by the prion protein gene (PRNP) impacts susceptibility to transmissible spongiform encephalopathies, including chronic wasting disease (CWD) in deer. The recent emergence of CWD in Northern European reindeer (Rangifer tarandus), moose (Alces alces alces) and red deer (Cervus elaphus), in parallel with the outbreak in North America, gives reason to investigate PRNP variation in European deer, to implement risk assessments and adjust CWD management for deer populations under threat. We here report PRNP-sequence data from 911 samples of German red, roe (Capreolus capreolus), sika (Cervus nippon) and fallow deer (Dama dama) as well as additional data from 26 Danish red deer close to the German border and four zoo species not native to Germany. No PRNP sequence variation was observed in roe and fallow deer, as previously described for populations across Europe. In contrast, a broad PRNP variation was detected in red deer, with non-synonymous polymorphisms at codons 98, 226 and 247 as well as synonymous mutations at codons 21, 78, 136 and 185. Moreover, a novel 24 bp deletion within the octapeptide repeat was detected. In summary, 14 genotypes were seen in red deer with significant differences in their geographical distribution and frequencies, including geographical clustering of certain genotypes, suggesting "PRNP-linages" in this species. Based on data from North American CWD and the genotyping results of the European CWD cases, we would predict that large proportions of wild cervids in Europe might be susceptible to CWD once introduced to naive populations. Article in Journal/Newspaper Alces alces Rangifer tarandus OpenAgrar (OA) Veterinary Research 55 1 |
institution |
Open Polar |
collection |
OpenAgrar (OA) |
op_collection_id |
ftopenagrar |
language |
English |
topic |
article Text ddc:570 PRNP -- Chronic wasting disease -- Denmark -- Germany -- cervid -- deer -- fallow deer -- genotype -- polymorphism -- red deer -- roe deer -- sika deer |
spellingShingle |
article Text ddc:570 PRNP -- Chronic wasting disease -- Denmark -- Germany -- cervid -- deer -- fallow deer -- genotype -- polymorphism -- red deer -- roe deer -- sika deer Ernst, Sonja Piestrzyńska-Kajtoch, Agata Gethmann, Jörn Natonek-Wiśniewska, Małgorzata Sadeghi, Balal Polak, Miroslaw P. Keller, Markus Gavier-Widén, Dolores Moazami-Goudarzi, Katayoun Houston, Fiona Groschup, Martin H. Fast, Christine Prion protein gene (PRNP) variation in German and Danish cervids |
topic_facet |
article Text ddc:570 PRNP -- Chronic wasting disease -- Denmark -- Germany -- cervid -- deer -- fallow deer -- genotype -- polymorphism -- red deer -- roe deer -- sika deer |
description |
The structure of cellular prion proteins encoded by the prion protein gene (PRNP) impacts susceptibility to transmissible spongiform encephalopathies, including chronic wasting disease (CWD) in deer. The recent emergence of CWD in Northern European reindeer (Rangifer tarandus), moose (Alces alces alces) and red deer (Cervus elaphus), in parallel with the outbreak in North America, gives reason to investigate PRNP variation in European deer, to implement risk assessments and adjust CWD management for deer populations under threat. We here report PRNP-sequence data from 911 samples of German red, roe (Capreolus capreolus), sika (Cervus nippon) and fallow deer (Dama dama) as well as additional data from 26 Danish red deer close to the German border and four zoo species not native to Germany. No PRNP sequence variation was observed in roe and fallow deer, as previously described for populations across Europe. In contrast, a broad PRNP variation was detected in red deer, with non-synonymous polymorphisms at codons 98, 226 and 247 as well as synonymous mutations at codons 21, 78, 136 and 185. Moreover, a novel 24 bp deletion within the octapeptide repeat was detected. In summary, 14 genotypes were seen in red deer with significant differences in their geographical distribution and frequencies, including geographical clustering of certain genotypes, suggesting "PRNP-linages" in this species. Based on data from North American CWD and the genotyping results of the European CWD cases, we would predict that large proportions of wild cervids in Europe might be susceptible to CWD once introduced to naive populations. |
format |
Article in Journal/Newspaper |
author |
Ernst, Sonja Piestrzyńska-Kajtoch, Agata Gethmann, Jörn Natonek-Wiśniewska, Małgorzata Sadeghi, Balal Polak, Miroslaw P. Keller, Markus Gavier-Widén, Dolores Moazami-Goudarzi, Katayoun Houston, Fiona Groschup, Martin H. Fast, Christine |
author_facet |
Ernst, Sonja Piestrzyńska-Kajtoch, Agata Gethmann, Jörn Natonek-Wiśniewska, Małgorzata Sadeghi, Balal Polak, Miroslaw P. Keller, Markus Gavier-Widén, Dolores Moazami-Goudarzi, Katayoun Houston, Fiona Groschup, Martin H. Fast, Christine |
author_sort |
Ernst, Sonja |
title |
Prion protein gene (PRNP) variation in German and Danish cervids |
title_short |
Prion protein gene (PRNP) variation in German and Danish cervids |
title_full |
Prion protein gene (PRNP) variation in German and Danish cervids |
title_fullStr |
Prion protein gene (PRNP) variation in German and Danish cervids |
title_full_unstemmed |
Prion protein gene (PRNP) variation in German and Danish cervids |
title_sort |
prion protein gene (prnp) variation in german and danish cervids |
publisher |
Springer Science and Business Media LLC |
publishDate |
2024 |
url |
https://doi.org/10.1186/s13567-024-01340-8 https://www.openagrar.de/receive/openagrar_mods_00098493 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00060751/SD2024258.pdf https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01340-8 |
genre |
Alces alces Rangifer tarandus |
genre_facet |
Alces alces Rangifer tarandus |
op_relation |
Veterinary research -- Vet Res -- 1297-9716 -- 0928-4249 -- 2012391-7 -- 1146298-x -- https://veterinaryresearch.biomedcentral.com/ -- https://link.springer.com/journal/13567 -- http://www.bibliothek.uni-regensburg.de/ezeit/?2012391 -- https://www.ncbi.nlm.nih.gov/pmc/journals/892/ -- http://www.vetres-archive.org//pages/article.php https://doi.org/10.1186/s13567-024-01340-8 https://www.openagrar.de/receive/openagrar_mods_00098493 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00060751/SD2024258.pdf https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01340-8 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ public info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s13567-024-01340-8 |
container_title |
Veterinary Research |
container_volume |
55 |
container_issue |
1 |
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1810487848419196928 |