Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain
Leptospirosis is a neglected zoonotic disease and one of the leading causes of zoonotic morbidity and mortality, particularly in resource-poor settings. Sri Lanka has one of the highest disease burdens worldwide, with occasional endemic leptospirosis outbreaks (2008, 2011). Rodents are considered th...
Published in: | PLOS Neglected Tropical Diseases |
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00082947 2023-05-15T18:05:41+02:00 Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain Sluydts, Vincent Sarathchandra, Siriwardana Rampalage Piscitelli, Anna Pia Van Houtte, Natalie Gryseels, Sophie Mayer-Scholl, Anne Bier, Nadja Seyhan Htwe, Nyo Me Jacob, Jens 2022 17 Seiten https://doi.org/10.1371/journal.pntd.0010757 https://www.openagrar.de/receive/openagrar_mods_00082947 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00049238/2022_0088.pdf https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010757&type=printable eng eng PLoS neglected tropical diseases -- PLoS Negl Trop Dis -- 1935-2735 -- 1935-2727 -- 2429704-5 -- http://www.plosntds.org/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2429704 https://doi.org/10.1371/journal.pntd.0010757 https://www.openagrar.de/receive/openagrar_mods_00082947 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00049238/2022_0088.pdf https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010757&type=printable https://creativecommons.org/licenses/by/4.0/ public info:eu-repo/semantics/openAccess CC-BY Text ddc:630 article Text 2022 ftopenagrar https://doi.org/10.1371/journal.pntd.0010757 2023-03-06T00:08:16Z Leptospirosis is a neglected zoonotic disease and one of the leading causes of zoonotic morbidity and mortality, particularly in resource-poor settings. Sri Lanka has one of the highest disease burdens worldwide, with occasional endemic leptospirosis outbreaks (2008, 2011). Rodents are considered the main wildlife reservoir, but due to a scarcity of studies it is unclear which particular species contributes to bacterial transmission and reservoir maintenance in this multi-host multi-parasite system. Several rodent species act as agricultural pests both in rice fields and in food storage facilities. To unravel the interactions among the small mammal communities, pathogenic Leptospira spp. and human transmission pathways, we collected animals from smallholder food storage facilities, where contact between humans and small mammals is most likely, and screened kidney tissue samples for Leptospira spp. using PCR. Samples were collected in three climatic zones along a rainfall gradient. Pathogenic Leptospira spp. were detected in small mammal communities in 37 (74%) out of 50 sampled farms and 61 (12%) out of 500 collected individuals were infected. The small mammal community was comprised of Rattus rattus (87.6%), Suncus shrews (8.8%), Bandicota spp. (2.8%) and Mus booduga (0.8%). Three pathogenic Leptospira spp. were identified, L. borgpetersenii (n = 34), L. interrogans (n = 15), and L. kirschneri (n = 1). Suncus shrews were commonly infected (32%), followed by B. indica (23%) and R. rattus (10%). L. borgpetersenii strains similar to strains previously extracted from human clinal samples in Sri Lanka were detected in R. rattus and Suncus shrews. L. interrogans was observed in R. rattus only. A single L. kirschneri infection was found in M. booduga. The presence of human pathogenic Leptospira species in an agricultural pest rodent (R. rattus) and in commensal shrews (Suncus) calls for management of these species in commensal settings. Further investigation of the interplay between pathogen and reservoir population ... Article in Journal/Newspaper Rattus rattus OpenAgrar (OA) PLOS Neglected Tropical Diseases 16 9 e0010757 |
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Text ddc:630 Sluydts, Vincent Sarathchandra, Siriwardana Rampalage Piscitelli, Anna Pia Van Houtte, Natalie Gryseels, Sophie Mayer-Scholl, Anne Bier, Nadja Seyhan Htwe, Nyo Me Jacob, Jens Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain |
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Text ddc:630 |
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Leptospirosis is a neglected zoonotic disease and one of the leading causes of zoonotic morbidity and mortality, particularly in resource-poor settings. Sri Lanka has one of the highest disease burdens worldwide, with occasional endemic leptospirosis outbreaks (2008, 2011). Rodents are considered the main wildlife reservoir, but due to a scarcity of studies it is unclear which particular species contributes to bacterial transmission and reservoir maintenance in this multi-host multi-parasite system. Several rodent species act as agricultural pests both in rice fields and in food storage facilities. To unravel the interactions among the small mammal communities, pathogenic Leptospira spp. and human transmission pathways, we collected animals from smallholder food storage facilities, where contact between humans and small mammals is most likely, and screened kidney tissue samples for Leptospira spp. using PCR. Samples were collected in three climatic zones along a rainfall gradient. Pathogenic Leptospira spp. were detected in small mammal communities in 37 (74%) out of 50 sampled farms and 61 (12%) out of 500 collected individuals were infected. The small mammal community was comprised of Rattus rattus (87.6%), Suncus shrews (8.8%), Bandicota spp. (2.8%) and Mus booduga (0.8%). Three pathogenic Leptospira spp. were identified, L. borgpetersenii (n = 34), L. interrogans (n = 15), and L. kirschneri (n = 1). Suncus shrews were commonly infected (32%), followed by B. indica (23%) and R. rattus (10%). L. borgpetersenii strains similar to strains previously extracted from human clinal samples in Sri Lanka were detected in R. rattus and Suncus shrews. L. interrogans was observed in R. rattus only. A single L. kirschneri infection was found in M. booduga. The presence of human pathogenic Leptospira species in an agricultural pest rodent (R. rattus) and in commensal shrews (Suncus) calls for management of these species in commensal settings. Further investigation of the interplay between pathogen and reservoir population ... |
format |
Article in Journal/Newspaper |
author |
Sluydts, Vincent Sarathchandra, Siriwardana Rampalage Piscitelli, Anna Pia Van Houtte, Natalie Gryseels, Sophie Mayer-Scholl, Anne Bier, Nadja Seyhan Htwe, Nyo Me Jacob, Jens |
author_facet |
Sluydts, Vincent Sarathchandra, Siriwardana Rampalage Piscitelli, Anna Pia Van Houtte, Natalie Gryseels, Sophie Mayer-Scholl, Anne Bier, Nadja Seyhan Htwe, Nyo Me Jacob, Jens |
author_sort |
Sluydts, Vincent |
title |
Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain |
title_short |
Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain |
title_full |
Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain |
title_fullStr |
Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain |
title_full_unstemmed |
Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain |
title_sort |
ecology and distribution of leptospira spp., reservoir hosts and environmental interaction in sri lanka, with identification of a new strain |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010757 https://www.openagrar.de/receive/openagrar_mods_00082947 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00049238/2022_0088.pdf https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010757&type=printable |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
PLoS neglected tropical diseases -- PLoS Negl Trop Dis -- 1935-2735 -- 1935-2727 -- 2429704-5 -- http://www.plosntds.org/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2429704 https://doi.org/10.1371/journal.pntd.0010757 https://www.openagrar.de/receive/openagrar_mods_00082947 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00049238/2022_0088.pdf https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010757&type=printable |
op_rights |
https://creativecommons.org/licenses/by/4.0/ public info:eu-repo/semantics/openAccess |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pntd.0010757 |
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PLOS Neglected Tropical Diseases |
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16 |
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9 |
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e0010757 |
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