No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022
Rodentia is the most speciose mammalian order, found across the globe, with some species occurring in close proximity to humans. Furthermore, rodents are known hosts for a variety of zoonotic pathogens. Among other animal species, rodents came into focus when the severe acute respiratory syndrome co...
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00082481 2023-05-15T15:56:38+02:00 No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022 Wernike, Kerstin Drewes, Stephan Mehl, Calvin Hesse, Christin Imholt, Christian Jacob, Jens Ulrich, Rainer G. Beer, Martin 2022 https://doi.org/10.3390/pathogens11101112 https://www.openagrar.de/receive/openagrar_mods_00082481 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048888/pathogens-11-01112.pdf https://www.mdpi.com/2076-0817/11/10/1112 eng eng Pathogens -- 2076-0817 -- 2695572-6 -- http://www.mdpi.com/journal/pathogens -- http://www.bibliothek.uni-regensburg.de/ezeit/?2695572 https://doi.org/10.3390/pathogens11101112 https://www.openagrar.de/receive/openagrar_mods_00082481 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048888/pathogens-11-01112.pdf https://www.mdpi.com/2076-0817/11/10/1112 public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess CC-BY Text ddc:570 coronavirus -- COVID-19 -- reservoir -- intermediate host -- Cricetidae -- Muridae article Text 2022 ftopenagrar https://doi.org/10.3390/pathogens11101112 2023-03-06T00:08:19Z Rodentia is the most speciose mammalian order, found across the globe, with some species occurring in close proximity to humans. Furthermore, rodents are known hosts for a variety of zoonotic pathogens. Among other animal species, rodents came into focus when the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spread through human populations across the globe, initially as laboratory animals to study the viral pathogenesis and to test countermeasures. Under experimental conditions, some rodent species including several cricetid species are susceptible to SARS-CoV-2 infection and a few of them can transmit the virus to conspecifics. To investigate whether SARS-CoV-2 is also spreading in wild rodent populations in Germany, we serologically tested samples of free-ranging bank voles (Myodes glareolus, n = 694), common voles (Microtus arvalis, n = 2), house mice (Mus musculus, n = 27), brown or Norway rats (Rattus norvegicus, n = 97) and Apodemus species (n = 8) for antibodies against the virus. The samples were collected from 2020 to 2022 in seven German federal states. All but one sample tested negative by a multispecies ELISA based on the receptor-binding domain (RBD) of SARS-CoV-2. The remaining sample, from a common vole collected in 2021, was within the inconclusive range of the RBD-ELISA, but this result could not be confirmed by a surrogate virus neutralization test as the sample gave a negative result in this test. These results indicate that SARS-CoV-2 has not become highly prevalent in wild rodent populations in Germany. Article in Journal/Newspaper Common vole Microtus arvalis OpenAgrar (OA) Norway Pathogens 11 10 1112 |
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English |
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Text ddc:570 coronavirus -- COVID-19 -- reservoir -- intermediate host -- Cricetidae -- Muridae |
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Text ddc:570 coronavirus -- COVID-19 -- reservoir -- intermediate host -- Cricetidae -- Muridae Wernike, Kerstin Drewes, Stephan Mehl, Calvin Hesse, Christin Imholt, Christian Jacob, Jens Ulrich, Rainer G. Beer, Martin No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022 |
topic_facet |
Text ddc:570 coronavirus -- COVID-19 -- reservoir -- intermediate host -- Cricetidae -- Muridae |
description |
Rodentia is the most speciose mammalian order, found across the globe, with some species occurring in close proximity to humans. Furthermore, rodents are known hosts for a variety of zoonotic pathogens. Among other animal species, rodents came into focus when the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spread through human populations across the globe, initially as laboratory animals to study the viral pathogenesis and to test countermeasures. Under experimental conditions, some rodent species including several cricetid species are susceptible to SARS-CoV-2 infection and a few of them can transmit the virus to conspecifics. To investigate whether SARS-CoV-2 is also spreading in wild rodent populations in Germany, we serologically tested samples of free-ranging bank voles (Myodes glareolus, n = 694), common voles (Microtus arvalis, n = 2), house mice (Mus musculus, n = 27), brown or Norway rats (Rattus norvegicus, n = 97) and Apodemus species (n = 8) for antibodies against the virus. The samples were collected from 2020 to 2022 in seven German federal states. All but one sample tested negative by a multispecies ELISA based on the receptor-binding domain (RBD) of SARS-CoV-2. The remaining sample, from a common vole collected in 2021, was within the inconclusive range of the RBD-ELISA, but this result could not be confirmed by a surrogate virus neutralization test as the sample gave a negative result in this test. These results indicate that SARS-CoV-2 has not become highly prevalent in wild rodent populations in Germany. |
format |
Article in Journal/Newspaper |
author |
Wernike, Kerstin Drewes, Stephan Mehl, Calvin Hesse, Christin Imholt, Christian Jacob, Jens Ulrich, Rainer G. Beer, Martin |
author_facet |
Wernike, Kerstin Drewes, Stephan Mehl, Calvin Hesse, Christin Imholt, Christian Jacob, Jens Ulrich, Rainer G. Beer, Martin |
author_sort |
Wernike, Kerstin |
title |
No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022 |
title_short |
No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022 |
title_full |
No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022 |
title_fullStr |
No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022 |
title_full_unstemmed |
No Evidence for the Presence of SARS-CoV-2 in Bank Voles and Other Rodents in Germany, 2020–2022 |
title_sort |
no evidence for the presence of sars-cov-2 in bank voles and other rodents in germany, 2020–2022 |
publishDate |
2022 |
url |
https://doi.org/10.3390/pathogens11101112 https://www.openagrar.de/receive/openagrar_mods_00082481 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048888/pathogens-11-01112.pdf https://www.mdpi.com/2076-0817/11/10/1112 |
geographic |
Norway |
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Norway |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_relation |
Pathogens -- 2076-0817 -- 2695572-6 -- http://www.mdpi.com/journal/pathogens -- http://www.bibliothek.uni-regensburg.de/ezeit/?2695572 https://doi.org/10.3390/pathogens11101112 https://www.openagrar.de/receive/openagrar_mods_00082481 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048888/pathogens-11-01112.pdf https://www.mdpi.com/2076-0817/11/10/1112 |
op_rights |
public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/pathogens11101112 |
container_title |
Pathogens |
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11 |
container_issue |
10 |
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1112 |
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1766392030789894144 |