Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe
In Europe, zoonotic Leptospira spp. and orthohantaviruses are mainly associated with specific rodent hosts. These pathogens cause febrile human diseases with similar symptoms and disease progression. In Lithuania, the presence of Dobrava-Belgrade orthohantavirus (DOBV), Tula orthohantavirus (TULV) a...
Published in: | Transboundary and Emerging Diseases |
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2022
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Online Access: | https://doi.org/10.1111/tbed.14470 https://www.openagrar.de/receive/openagrar_mods_00077545 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048838/SD202260.pdf https://onlinelibrary.wiley.com/doi/10.1111/tbed.14470 |
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00077545 2024-09-15T18:02:50+00:00 Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe Jeske, Kathrin Schulz, Jana Tekemen, Duygu Balčiauskas, Linas Balčiauskienė, Laima Hiltbrunner, Melanie Drewes, Stephan Mayer-Scholl, Anne Heckel, Gerald Ulrich, Rainer G. 2022-02-04 https://doi.org/10.1111/tbed.14470 https://www.openagrar.de/receive/openagrar_mods_00077545 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048838/SD202260.pdf https://onlinelibrary.wiley.com/doi/10.1111/tbed.14470 eng eng Transboundary and Emerging Diseases -- Transbound Emerg Dis -- 1865-1682 -- 1865-1674 -- 2414822-2 -- 2408860-2 -- 10.1111/(ISSN)1865-1682 -- https://www.hindawi.com/journals/tbed/ -- https://onlinelibrary.wiley.com/journal/18651682 -- http://www.bibliothek.uni-regensburg.de/ezeit/?2414822 https://doi.org/10.1111/tbed.14470 https://www.openagrar.de/receive/openagrar_mods_00077545 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048838/SD202260.pdf https://onlinelibrary.wiley.com/doi/10.1111/tbed.14470 https://creativecommons.org/licenses/by-nc-nd/4.0/ public info:eu-repo/semantics/openAccess article Text ddc:570 Reservoir Leptospira Kirschneri Puumala Orthohantavirus Tula Orthohantavirus Dobrava-belgrade Orthohantavirus article Text doc-type:article 2022 ftopenagrar https://doi.org/10.1111/tbed.1447010.1111/(ISSN)1865-1682 2024-07-08T23:56:24Z In Europe, zoonotic Leptospira spp. and orthohantaviruses are mainly associated with specific rodent hosts. These pathogens cause febrile human diseases with similar symptoms and disease progression. In Lithuania, the presence of Dobrava-Belgrade orthohantavirus (DOBV), Tula orthohantavirus (TULV) and Leptospira spp. in rodent reservoirs is still unknown and Puumala orthohantavirus (PUUV) was detected in bank voles (Clethrionomys glareolus) at only one site. Therefore, we collected and screened 1617 rodents and insectivores from Lithuania for zoonotic (re-)emerging Leptospira and orthohantaviruses. We detected Leptospira-DNA in six rodent species, namely striped field mouse (Apodemus agrarius), yellow-necked mouse (Apodemus flavicollis), bank vole, common vole (Microtus arvalis), field vole (M. agrestis) and root vole (M. oeconomus). Leptospira DNA was detected with an overall mean prevalence of 4.4% (range 3.7 - 7.9% per rodent species). We detected DOBV RNA in 5.6% of the striped field mice, PUUV RNA in 1% of bank voles and TULV RNA in 4.6% of common voles, but no Leptospira DNA in shrews and no hantavirus-Leptospira coinfections in rodents. Based on the complete coding sequences of the three genome segments, two distant DOBV phylogenetic lineages in striped field mice, one PUUV strain in bank voles and two TULV strains in common voles were identified. The Leptospira prevalence for striped field mice and yellow-necked mice indicated a significant negative effect of the distance to water points. The detection of (re-)emerging human pathogenic Leptospira and three orthohantaviruses in rodent reservoirs in Lithuania calls for increased awareness of public health institutions and allows the improvement of molecular diagnostics for pathogen identification. This article is protected by copyright. All rights reserved. Article in Journal/Newspaper Common vole Microtus arvalis OpenAgrar (OA) Transboundary and Emerging Diseases |
institution |
Open Polar |
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OpenAgrar (OA) |
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ftopenagrar |
language |
English |
topic |
article Text ddc:570 Reservoir Leptospira Kirschneri Puumala Orthohantavirus Tula Orthohantavirus Dobrava-belgrade Orthohantavirus |
spellingShingle |
article Text ddc:570 Reservoir Leptospira Kirschneri Puumala Orthohantavirus Tula Orthohantavirus Dobrava-belgrade Orthohantavirus Jeske, Kathrin Schulz, Jana Tekemen, Duygu Balčiauskas, Linas Balčiauskienė, Laima Hiltbrunner, Melanie Drewes, Stephan Mayer-Scholl, Anne Heckel, Gerald Ulrich, Rainer G. Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe |
topic_facet |
article Text ddc:570 Reservoir Leptospira Kirschneri Puumala Orthohantavirus Tula Orthohantavirus Dobrava-belgrade Orthohantavirus |
description |
In Europe, zoonotic Leptospira spp. and orthohantaviruses are mainly associated with specific rodent hosts. These pathogens cause febrile human diseases with similar symptoms and disease progression. In Lithuania, the presence of Dobrava-Belgrade orthohantavirus (DOBV), Tula orthohantavirus (TULV) and Leptospira spp. in rodent reservoirs is still unknown and Puumala orthohantavirus (PUUV) was detected in bank voles (Clethrionomys glareolus) at only one site. Therefore, we collected and screened 1617 rodents and insectivores from Lithuania for zoonotic (re-)emerging Leptospira and orthohantaviruses. We detected Leptospira-DNA in six rodent species, namely striped field mouse (Apodemus agrarius), yellow-necked mouse (Apodemus flavicollis), bank vole, common vole (Microtus arvalis), field vole (M. agrestis) and root vole (M. oeconomus). Leptospira DNA was detected with an overall mean prevalence of 4.4% (range 3.7 - 7.9% per rodent species). We detected DOBV RNA in 5.6% of the striped field mice, PUUV RNA in 1% of bank voles and TULV RNA in 4.6% of common voles, but no Leptospira DNA in shrews and no hantavirus-Leptospira coinfections in rodents. Based on the complete coding sequences of the three genome segments, two distant DOBV phylogenetic lineages in striped field mice, one PUUV strain in bank voles and two TULV strains in common voles were identified. The Leptospira prevalence for striped field mice and yellow-necked mice indicated a significant negative effect of the distance to water points. The detection of (re-)emerging human pathogenic Leptospira and three orthohantaviruses in rodent reservoirs in Lithuania calls for increased awareness of public health institutions and allows the improvement of molecular diagnostics for pathogen identification. This article is protected by copyright. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Jeske, Kathrin Schulz, Jana Tekemen, Duygu Balčiauskas, Linas Balčiauskienė, Laima Hiltbrunner, Melanie Drewes, Stephan Mayer-Scholl, Anne Heckel, Gerald Ulrich, Rainer G. |
author_facet |
Jeske, Kathrin Schulz, Jana Tekemen, Duygu Balčiauskas, Linas Balčiauskienė, Laima Hiltbrunner, Melanie Drewes, Stephan Mayer-Scholl, Anne Heckel, Gerald Ulrich, Rainer G. |
author_sort |
Jeske, Kathrin |
title |
Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe |
title_short |
Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe |
title_full |
Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe |
title_fullStr |
Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe |
title_full_unstemmed |
Cocirculation of Leptospira spp. and multiple orthohantaviruses in rodents, Lithuania, Northern Europe |
title_sort |
cocirculation of leptospira spp. and multiple orthohantaviruses in rodents, lithuania, northern europe |
publishDate |
2022 |
url |
https://doi.org/10.1111/tbed.14470 https://www.openagrar.de/receive/openagrar_mods_00077545 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048838/SD202260.pdf https://onlinelibrary.wiley.com/doi/10.1111/tbed.14470 |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_relation |
Transboundary and Emerging Diseases -- Transbound Emerg Dis -- 1865-1682 -- 1865-1674 -- 2414822-2 -- 2408860-2 -- 10.1111/(ISSN)1865-1682 -- https://www.hindawi.com/journals/tbed/ -- https://onlinelibrary.wiley.com/journal/18651682 -- http://www.bibliothek.uni-regensburg.de/ezeit/?2414822 https://doi.org/10.1111/tbed.14470 https://www.openagrar.de/receive/openagrar_mods_00077545 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00048838/SD202260.pdf https://onlinelibrary.wiley.com/doi/10.1111/tbed.14470 |
op_rights |
https://creativecommons.org/licenses/by-nc-nd/4.0/ public info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1111/tbed.1447010.1111/(ISSN)1865-1682 |
container_title |
Transboundary and Emerging Diseases |
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1810440239277146112 |