Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020
Lyssaviruses are the causative agents for rabies, a zoonotic and fatal disease. Bats are the ancestral reservoir host for lyssaviruses, and at least three different lyssaviruses have been found in bats from Germany. Across Europe, novel lyssaviruses were identified in bats recently and occasional sp...
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00073069 2024-09-15T18:18:59+00:00 Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad Martin 2021-08-03 https://doi.org/10.3390/v13081538 https://www.openagrar.de/receive/openagrar_mods_00073069 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00040925/SD2021393.pdf https://www.mdpi.com/1999-4915/13/8/1538 eng eng Viruses -- 1999-4915 -- 2516098-9 -- http://www.mdpi.com/journal/viruses -- https://www.ncbi.nlm.nih.gov/pmc/journals/1559/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2516098 https://doi.org/10.3390/v13081538 https://www.openagrar.de/receive/openagrar_mods_00073069 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00040925/SD2021393.pdf https://www.mdpi.com/1999-4915/13/8/1538 public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Text article ddc:570 bat lyssavirus -- bat rabies surveillance -- European bat lyssavirus 1 (EBLV-1) -- Bokeloh bat lyssavirus (BBLV) -- zoonosis article Text doc-type:article 2021 ftopenagrar https://doi.org/10.3390/v13081538 2024-07-08T23:56:24Z Lyssaviruses are the causative agents for rabies, a zoonotic and fatal disease. Bats are the ancestral reservoir host for lyssaviruses, and at least three different lyssaviruses have been found in bats from Germany. Across Europe, novel lyssaviruses were identified in bats recently and occasional spillover infections in other mammals and human cases highlight their public health relevance. Here, we report the results from an enhanced passive bat rabies surveillance that encompasses samples without human contact that would not be tested under routine conditions. To this end, 1236 bat brain samples obtained between 2018 and 2020 were screened for lyssaviruses via several RT-qPCR assays. European bat lyssavirus type 1 (EBLV-1) was dominant, with 15 positives exclusively found in serotine bats (Eptesicus serotinus) from northern Germany. Additionally, when an archived set of bat samples that had tested negative for rabies by the FAT were screened in the process of assay validation, four samples tested EBLV-1 positive, including two detected in Pipistrellus pipistrellus. Subsequent phylogenetic analysis of 17 full genomes assigned all except one of these viruses to the A1 cluster of the EBLV-1a sub-lineage. Furthermore, we report here another Bokeloh bat lyssavirus (BBLV) infection in a Natterer’s bat (Myotis nattereri) found in Lower Saxony, the tenth reported case of this novel bat lyssavirus. Article in Journal/Newspaper Myotis nattereri Pipistrellus pipistrellus OpenAgrar (OA) Viruses 13 8 1538 |
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Open Polar |
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OpenAgrar (OA) |
op_collection_id |
ftopenagrar |
language |
English |
topic |
Text article ddc:570 bat lyssavirus -- bat rabies surveillance -- European bat lyssavirus 1 (EBLV-1) -- Bokeloh bat lyssavirus (BBLV) -- zoonosis |
spellingShingle |
Text article ddc:570 bat lyssavirus -- bat rabies surveillance -- European bat lyssavirus 1 (EBLV-1) -- Bokeloh bat lyssavirus (BBLV) -- zoonosis Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad Martin Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
topic_facet |
Text article ddc:570 bat lyssavirus -- bat rabies surveillance -- European bat lyssavirus 1 (EBLV-1) -- Bokeloh bat lyssavirus (BBLV) -- zoonosis |
description |
Lyssaviruses are the causative agents for rabies, a zoonotic and fatal disease. Bats are the ancestral reservoir host for lyssaviruses, and at least three different lyssaviruses have been found in bats from Germany. Across Europe, novel lyssaviruses were identified in bats recently and occasional spillover infections in other mammals and human cases highlight their public health relevance. Here, we report the results from an enhanced passive bat rabies surveillance that encompasses samples without human contact that would not be tested under routine conditions. To this end, 1236 bat brain samples obtained between 2018 and 2020 were screened for lyssaviruses via several RT-qPCR assays. European bat lyssavirus type 1 (EBLV-1) was dominant, with 15 positives exclusively found in serotine bats (Eptesicus serotinus) from northern Germany. Additionally, when an archived set of bat samples that had tested negative for rabies by the FAT were screened in the process of assay validation, four samples tested EBLV-1 positive, including two detected in Pipistrellus pipistrellus. Subsequent phylogenetic analysis of 17 full genomes assigned all except one of these viruses to the A1 cluster of the EBLV-1a sub-lineage. Furthermore, we report here another Bokeloh bat lyssavirus (BBLV) infection in a Natterer’s bat (Myotis nattereri) found in Lower Saxony, the tenth reported case of this novel bat lyssavirus. |
format |
Article in Journal/Newspaper |
author |
Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad Martin |
author_facet |
Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad Martin |
author_sort |
Klein, Antonia |
title |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_short |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_full |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_fullStr |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_full_unstemmed |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_sort |
retrospective enhanced bat lyssavirus surveillance in germany between 2018–2020 |
publishDate |
2021 |
url |
https://doi.org/10.3390/v13081538 https://www.openagrar.de/receive/openagrar_mods_00073069 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00040925/SD2021393.pdf https://www.mdpi.com/1999-4915/13/8/1538 |
genre |
Myotis nattereri Pipistrellus pipistrellus |
genre_facet |
Myotis nattereri Pipistrellus pipistrellus |
op_relation |
Viruses -- 1999-4915 -- 2516098-9 -- http://www.mdpi.com/journal/viruses -- https://www.ncbi.nlm.nih.gov/pmc/journals/1559/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2516098 https://doi.org/10.3390/v13081538 https://www.openagrar.de/receive/openagrar_mods_00073069 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00040925/SD2021393.pdf https://www.mdpi.com/1999-4915/13/8/1538 |
op_rights |
public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/v13081538 |
container_title |
Viruses |
container_volume |
13 |
container_issue |
8 |
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1538 |
_version_ |
1810457091019636736 |