Hantavirus - Leptospira coinfections in small mammals from central Germany
European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the...
Published in: | Epidemiology and Infection |
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2021
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00067415 2024-09-15T18:18:46+00:00 Hantavirus - Leptospira coinfections in small mammals from central Germany Jeske, Kathrin Jacob, Jens Drewes, Stephan Pfeffer, Martin Heckel, Gerald Ulrich, Rainer G. Imholt, Christian 2021-02-22 https://doi.org/10.1017/S0950268821000443 https://www.openagrar.de/receive/openagrar_mods_00067415 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00037035/SD202199.pdf https://www.cambridge.org/core/journals/epidemiology-and-infection/article/hantavirus-leptospira-coinfections-in-small-mammals-from-central-germany/C72484ABA3264712AD630AF6BE90BC52 eng eng Epidemiology and Infection -- Epidemiol Infect -- 1469-4409 -- 0950-2688 -- 1470211-3 -- 632982-2 -- https://www.cambridge.org/core/journals/epidemiology-and-infection/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?1470211 -- http://www.jstor.org/action/showPublication?journalCode=epidinfe -- https://www.cambridge.org/core/journals/epidemiology-and-infection/information/converting-to-open-access-in-january-2019 https://doi.org/10.1017/S0950268821000443 https://www.openagrar.de/receive/openagrar_mods_00067415 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00037035/SD202199.pdf https://www.cambridge.org/core/journals/epidemiology-and-infection/article/hantavirus-leptospira-coinfections-in-small-mammals-from-central-germany/C72484ABA3264712AD630AF6BE90BC52 public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Text article ddc:570 article Text doc-type:article 2021 ftopenagrar https://doi.org/10.1017/S0950268821000443 2024-07-08T23:56:25Z European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles (Microtus agrestis) with 54.5% (6/11) and common voles (Microtus arvalis) with 30.3% (205/676). Leptospira–hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. Article in Journal/Newspaper Microtus arvalis OpenAgrar (OA) Epidemiology and Infection 149 |
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Text article ddc:570 Jeske, Kathrin Jacob, Jens Drewes, Stephan Pfeffer, Martin Heckel, Gerald Ulrich, Rainer G. Imholt, Christian Hantavirus - Leptospira coinfections in small mammals from central Germany |
topic_facet |
Text article ddc:570 |
description |
European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles (Microtus agrestis) with 54.5% (6/11) and common voles (Microtus arvalis) with 30.3% (205/676). Leptospira–hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. |
format |
Article in Journal/Newspaper |
author |
Jeske, Kathrin Jacob, Jens Drewes, Stephan Pfeffer, Martin Heckel, Gerald Ulrich, Rainer G. Imholt, Christian |
author_facet |
Jeske, Kathrin Jacob, Jens Drewes, Stephan Pfeffer, Martin Heckel, Gerald Ulrich, Rainer G. Imholt, Christian |
author_sort |
Jeske, Kathrin |
title |
Hantavirus - Leptospira coinfections in small mammals from central Germany |
title_short |
Hantavirus - Leptospira coinfections in small mammals from central Germany |
title_full |
Hantavirus - Leptospira coinfections in small mammals from central Germany |
title_fullStr |
Hantavirus - Leptospira coinfections in small mammals from central Germany |
title_full_unstemmed |
Hantavirus - Leptospira coinfections in small mammals from central Germany |
title_sort |
hantavirus - leptospira coinfections in small mammals from central germany |
publishDate |
2021 |
url |
https://doi.org/10.1017/S0950268821000443 https://www.openagrar.de/receive/openagrar_mods_00067415 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00037035/SD202199.pdf https://www.cambridge.org/core/journals/epidemiology-and-infection/article/hantavirus-leptospira-coinfections-in-small-mammals-from-central-germany/C72484ABA3264712AD630AF6BE90BC52 |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_relation |
Epidemiology and Infection -- Epidemiol Infect -- 1469-4409 -- 0950-2688 -- 1470211-3 -- 632982-2 -- https://www.cambridge.org/core/journals/epidemiology-and-infection/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?1470211 -- http://www.jstor.org/action/showPublication?journalCode=epidinfe -- https://www.cambridge.org/core/journals/epidemiology-and-infection/information/converting-to-open-access-in-january-2019 https://doi.org/10.1017/S0950268821000443 https://www.openagrar.de/receive/openagrar_mods_00067415 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00037035/SD202199.pdf https://www.cambridge.org/core/journals/epidemiology-and-infection/article/hantavirus-leptospira-coinfections-in-small-mammals-from-central-germany/C72484ABA3264712AD630AF6BE90BC52 |
op_rights |
public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1017/S0950268821000443 |
container_title |
Epidemiology and Infection |
container_volume |
149 |
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1810456846420410368 |