Genome-wide association analysis for lethal brachycephalic-like facial dysmorphia in Labrador Retrievers

• Published in: Animal Genetics
• Main Authors: Vasiliadis, D., Dierks, Claudia, Hoffmann, H., Hellige, M., Hewicker-Trautwein, M., Metzger, J., Distl, O.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2019
• Subjects: Text; ddc:570; association; Canis lupus familiaris; facial dysmorphia; RPS6KA3; X chromosome; Lowry; Canis lupus
• Online Access: https://doi.org/10.1111/age.12875; https://www.openagrar.de/receive/openagrar_mods_00054748; https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00026147/SD2019531_SD202035.pdf; https://onlinelibrary.wiley.com/doi/full/10.1111/age.12875

A GWAS was performed for inborn X-linked facial dysmorphia with severe growth retardation in Labrador Retrievers. This lethal condition was mapped on the X chromosome at 17–21 Mb and supported by eight SNPs in complete LD. Dams of affected male puppies were heterozygous for the significantly associa...