Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus
The diversity of viruses probably exceeds biodiversity of eukaryotes, but little is known about the origin and emergence of novel virus species. Experimentation and disease outbreak investigations have allowed the characterization of rapid molecular virus adaptation. However, the processes leading t...
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Online Access: | https://doi.org/10.1371/journal.pbio.3000142 https://www.openagrar.de/receive/openagrar_mods_00047467 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00020332/journal.pbio.3000142.pdf https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000142 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382107/ |
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00047467 2024-09-15T18:02:50+00:00 Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus Saxenhofer, Moritz Schmidt, Sabrina Ulrich, Rainer Heckel, Gerald 2019-02-20 https://doi.org/10.1371/journal.pbio.3000142 https://www.openagrar.de/receive/openagrar_mods_00047467 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00020332/journal.pbio.3000142.pdf https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000142 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382107/ eng eng PLoS Biology -- PLoS Biol -- 1544-9173 -- 1545-7885 -- 2126776-5 -- 2126773-X -- http://www.plosbiology.org/ -- https://www.ncbi.nlm.nih.gov/pmc/journals/212/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2126773 https://doi.org/10.1371/journal.pbio.3000142 https://www.openagrar.de/receive/openagrar_mods_00047467 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00020332/journal.pbio.3000142.pdf https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000142 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382107/ public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Text article ddc:570 voles -- Viral evolution -- Phylogeography -- Sequence assembly tools -- Nucleotide sequencing -- Mitochondrial DNA -- Phylogenetics -- Speciation article Text doc-type:article 2019 ftopenagrar https://doi.org/10.1371/journal.pbio.3000142 2024-07-08T23:56:25Z The diversity of viruses probably exceeds biodiversity of eukaryotes, but little is known about the origin and emergence of novel virus species. Experimentation and disease outbreak investigations have allowed the characterization of rapid molecular virus adaptation. However, the processes leading to the establishment of functionally distinct virus taxa in nature remain obscure. Here, we demonstrate that incipient speciation in a natural host species has generated distinct ecological niches leading to adaptive isolation in an RNA virus. We found a very strong association between the distributions of two major phylogenetic clades in Tula orthohantavirus (TULV) and the rodent host lineages in a natural hybrid zone of the European common vole (Microtus arvalis). The spatial transition between the virus clades in replicated geographic clines is at least eight times narrower than between the hybridizing host lineages. This suggests a strong barrier for effective virus transmission despite frequent dispersal and gene flow among local host populations, and translates to a complete turnover of the adaptive background of TULV within a few hundred meters in the open, unobstructed landscape. Genetic differences between TULV clades are homogenously distributed in the genomes and mostly synonymous (93.1%), except for a cluster of nonsynonymous changes in the 5′ region of the viral envelope glycoprotein gene, potentially involved in host-driven isolation. Evolutionary relationships between TULV clades indicate an emergence of these viruses through rapid differential adaptation to the previously diverged host lineages that resulted in levels of ecological isolation exceeding the progress of speciation in their vertebrate hosts. Article in Journal/Newspaper Common vole Microtus arvalis OpenAgrar (OA) PLOS Biology 17 2 e3000142 |
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Open Polar |
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OpenAgrar (OA) |
op_collection_id |
ftopenagrar |
language |
English |
topic |
Text article ddc:570 voles -- Viral evolution -- Phylogeography -- Sequence assembly tools -- Nucleotide sequencing -- Mitochondrial DNA -- Phylogenetics -- Speciation |
spellingShingle |
Text article ddc:570 voles -- Viral evolution -- Phylogeography -- Sequence assembly tools -- Nucleotide sequencing -- Mitochondrial DNA -- Phylogenetics -- Speciation Saxenhofer, Moritz Schmidt, Sabrina Ulrich, Rainer Heckel, Gerald Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus |
topic_facet |
Text article ddc:570 voles -- Viral evolution -- Phylogeography -- Sequence assembly tools -- Nucleotide sequencing -- Mitochondrial DNA -- Phylogenetics -- Speciation |
description |
The diversity of viruses probably exceeds biodiversity of eukaryotes, but little is known about the origin and emergence of novel virus species. Experimentation and disease outbreak investigations have allowed the characterization of rapid molecular virus adaptation. However, the processes leading to the establishment of functionally distinct virus taxa in nature remain obscure. Here, we demonstrate that incipient speciation in a natural host species has generated distinct ecological niches leading to adaptive isolation in an RNA virus. We found a very strong association between the distributions of two major phylogenetic clades in Tula orthohantavirus (TULV) and the rodent host lineages in a natural hybrid zone of the European common vole (Microtus arvalis). The spatial transition between the virus clades in replicated geographic clines is at least eight times narrower than between the hybridizing host lineages. This suggests a strong barrier for effective virus transmission despite frequent dispersal and gene flow among local host populations, and translates to a complete turnover of the adaptive background of TULV within a few hundred meters in the open, unobstructed landscape. Genetic differences between TULV clades are homogenously distributed in the genomes and mostly synonymous (93.1%), except for a cluster of nonsynonymous changes in the 5′ region of the viral envelope glycoprotein gene, potentially involved in host-driven isolation. Evolutionary relationships between TULV clades indicate an emergence of these viruses through rapid differential adaptation to the previously diverged host lineages that resulted in levels of ecological isolation exceeding the progress of speciation in their vertebrate hosts. |
format |
Article in Journal/Newspaper |
author |
Saxenhofer, Moritz Schmidt, Sabrina Ulrich, Rainer Heckel, Gerald |
author_facet |
Saxenhofer, Moritz Schmidt, Sabrina Ulrich, Rainer Heckel, Gerald |
author_sort |
Saxenhofer, Moritz |
title |
Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus |
title_short |
Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus |
title_full |
Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus |
title_fullStr |
Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus |
title_full_unstemmed |
Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus |
title_sort |
secondary contact between diverged host lineages entails ecological speciation in a european hantavirus |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pbio.3000142 https://www.openagrar.de/receive/openagrar_mods_00047467 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00020332/journal.pbio.3000142.pdf https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000142 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382107/ |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_relation |
PLoS Biology -- PLoS Biol -- 1544-9173 -- 1545-7885 -- 2126776-5 -- 2126773-X -- http://www.plosbiology.org/ -- https://www.ncbi.nlm.nih.gov/pmc/journals/212/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2126773 https://doi.org/10.1371/journal.pbio.3000142 https://www.openagrar.de/receive/openagrar_mods_00047467 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00020332/journal.pbio.3000142.pdf https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000142 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382107/ |
op_rights |
public https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pbio.3000142 |
container_title |
PLOS Biology |
container_volume |
17 |
container_issue |
2 |
container_start_page |
e3000142 |
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1810440238072332288 |