Sequences of the Botulinal Neurotoxin-e Derived from Clostridium-Botulinum Type-e (Strain-Beluga) and Clostridium-Butyricum (Strains Atcc-43181 and Atcc-43755)
Recently, it has been shown that two Clostridium butyricum strains (ATCC 43181 and ATCC 43755), isolated from cases of infant botulism, produce a botulinal neurotoxin type E (BoNT/E). Here we have determined the nucleotide sequences of the BoNT/E genes of these two C. butyricum strains and from C. b...
Main Authors: | , , , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
1992
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Subjects: | |
Online Access: | https://www.openagrar.de/receive/openagrar_mods_00038982 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00013044/SD19925.pdf |
Summary: | Recently, it has been shown that two Clostridium butyricum strains (ATCC 43181 and ATCC 43755), isolated from cases of infant botulism, produce a botulinal neurotoxin type E (BoNT/E). Here we have determined the nucleotide sequences of the BoNT/E genes of these two C. butyricum strains and from C. botulinum E strain Beluga. We show that the sequences of the BoNT/E genes from the two C. butyricum strains are identical and differ in only 64 positions resulting in 39 amino acid changes (97% identity at the amino acid level) from that derived from C. botulinum. Our data suggest a transfer of the BoNT/E gene from C. botulinum to the originally nontoxigenic C. butyricum strains. |
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