Scientific Opinion on the safety and efficacy of Ronozyme® P (6-phytase) as a feed additive for salmonids

• Published in: EFSA Journal
• Main Authors: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Mézes, M.
• Other Authors: Aquilina, G., Bories, G., Brantom, P., Chesson, A., Cocconcelli, P. S., de Knecht, J., Dierick, N. A., Gralak, M. A., Gropp, J., Halle, Ingrid, Kroker, R., Leng, L., Lundebye Haldorsen, A. K., Mantovani, A., Renshaw, D., Saarela, M.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2010
• Subjects: Text; article; ddc:630; Zootechnical additives; digestibility enhancers; substances which favourably affect the environment; 6-phytase; salmonids; safety and efficacy; Atlantic salmon; Salmo salar
• Online Access: https://doi.org/10.2903/j.efsa.2010.1915; https://www.openagrar.de/receive/openagrar_mods_00035858; https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00010026/SD2010576.pdf

Ronozyme® P is a liquid preparation of 6-phytase produced by a genetically modified strain of Aspergillus oryzae. The safety of the genetic modification of the current production strain has been previously established by EFSA in 2004. The product has been fully described in previous opinions and the safety of the product for the consumers, users and the environment has been assessed. In the view of the FEEDAP Panel, the use of the product in salmonids would not affect the conclusions reached in previous opinions. The results from a tolerance trial performed in rainbow trout (Oncorhynchus mykiss), where fish were fed 100-fold the maximum recommended dose, showed that Ronozyme® P is safe for salmonids at the maximum dose of 2000 FYT/kg. Five short-term efficacy studies (four with rainbow trout and one with Atlantic salmon (Salmo salar)) were performed with the additive. Phosphorus utilisation was improved in two trials performed in rainbow trout at a dose level of 500 FYT/kg and above, and in one trial performed in Atlantic salmon at a dose of 750 FYT/kg and above. Therefore, it is concluded that Ronozyme® P is efficacious in salmonids at the minimum recommended dose of 750 FYT/kg. The use of the additive allows the use of diets with a lower level of inorganic P, which may in turn reduce the excretion of P.